Delavirdine Brand Name– Rescriptor
What is Delavirdine
Delavirdine is an oral, non-nucleoside reverse transcriptase inhibitor (NNRTI) indicated for the treatment of HIV infection in patients 16 years and older.
Delavirdine MUST always be administered in combination with other antiretroviral medications, as resistance develops rapidly when delavirdine is administered as monotherapy.
The main toxicity associated with delavirdine therapy is rash.
Drug-induced rashes usually develop within 1 to 3 weeks of treatment initiation and resolve in 3 to 14 days. Use of an alternative antiretroviral medication should be considered for patients who experience severe rash with delavirdine.
Indications
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
Side Effects
- abdominal pain
- agitation
- alopecia
- amenorrhea
- amnesia
- angioedema
- anorexia
- anxiety
- appetite stimulation
- arthralgia
- asthenia
- blepharitis
- blurred vision
- bone pain
- bullous rash
- candidiasis
- cardiomyopathy
- chills
- colitis
- confusion
- conjunctivitis
- constipation
- cough
- Cushingoid features
- depression
- diaphoresis
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- dysphagia
- dyspnea
- ecchymosis
- edema
- elevated hepatic enzymes
- emotional lability
- eosinophilia
- epididymitis
- epistaxis
- eructation
- erythema
- erythema multiforme
- euphoria
- fatigue
- fecal incontinence
- fever
- flatulence
- folliculitis
- gastroesophageal reflux
- GI bleeding
- gingivitis
- gynecomastia
- hallucinations
- headache
- hematuria
- hemolytic anemia
- hepatic failure
- hepatitis
- hepatomegaly
- hiccups
- hyperamylasemia
- hyperbilirubinemia
- hyperesthesia
- hyperglycemia
- hyperkalemia
- hyperreflexia
- hypertension
- hypertonia
- hypertriglyceridemia
- hyperuricemia
- hypocalcemia
- hypoesthesia
- hypoglycemia
- hyponatremia
- hypophosphatemia
- impaired cognition
- impotence (erectile dysfunction)
- infection
- influenza
- insomnia
- jaundice
- laryngospasm
- leukopenia
- libido decrease
- lipodystrophy
- lymphadenopathy
- maculopapular rash
- malaise
- mania
- migraine
- muscle cramps
- muscle paralysis
- myalgia
- nausea
- nocturia
- oral ulceration
- orthostatic hypotension
- otalgia
- pallor
- pancreatitis
- pancytopenia
- paranoia
- parosmia
- peripheral neuropathy
- petechiae
- pharyngitis
- photophobia
- polydipsia
- polyuria
- proteinuria
- pruritus
- pseudomembranous colitis
- purpura
- rash
- renal failure (unspecified)
- rhabdomyolysis
- rhinitis
- seborrhea
- sialadenitis
- sinusitis
- skin discoloration
- skin ulcer
- Stevens-Johnson syndrome
- synovitis
- tetany
- thrombocytopenia
- tinnitus
- tremor
- urticaria
- vasculitis
- vertigo
- vesicular rash
- vomiting
- weakness
- weight gain
- weight loss
- xerophthalmia
- xerosis
- xerostomia
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum lipid profile
- urinalysis
Contraindications
- achlorhydria
- autoimmune disease
- breast-feeding
- children
- exfoliative dermatitis
- Graves’ disease
- Guillain-Barre syndrome
- hepatic disease
- hepatitis
- hepatitis B and HIV coinfection
- hepatitis C and HIV coinfection
- human immunodeficiency virus (HIV) infection resistance
- immune reconstitution syndrome
- infants
- neonates
- pregnancy
Interactions
- Abemaciclib
- Acalabrutinib
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Adefovir
- Ado-Trastuzumab emtansine
- Alfentanil
- Alfuzosin
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Almotriptan
- Alosetron
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamines
- Amprenavir
- Antacids
- Apalutamide
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir
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- Brompheniramine; Dextromethorphan; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
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- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
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- Desipramine
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexlansoprazole
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diclofenac
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- Duvelisib
- Echinacea
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- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
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- Ethinyl Estradiol; Desogestrel
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- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Famotidine
- Famotidine; Ibuprofen
- Fedratinib
- Felodipine
- Fentanyl
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- Fluoxetine; Olanzapine
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- Fluticasone
- Fluticasone; Salmeterol
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- Fluvastatin
- food
- Formoterol; Mometasone
- Fosamprenavir
- Fosphenytoin
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- Gefitinib
- Gilteritinib
- Glasdegib
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- H2-blockers
- Halofantrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
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- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Ibrutinib
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- Oritavancin
- Orlistat
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