Demeclocycline

Demeclocycline Brand Name– Declomycin

What is Demeclocycline

Demeclocycline is a tetracycline antibiotic. It is classified as intermediate in action duration between tetracycline and doxycycline, although this classification scheme is somewhat artificial since tetracycline can be dosed at longer intervals than usually occurs in clinical practice.

Although demeclocycline has activity similar to the other tetracyclines, its main clinical use is to treat inappropriate secretion of ADH secondary to its ability to produce nephrogenic diabetes insipidus.

Photosensitivity is more frequent and more severe with demeclocycline than with other tetracyclines.

Demeclocycline was approved by the FDA in 1960.

Indications

  1. Acinetobacter sp.
  2. acne vulgaris
  3. Actinomyces israelii
  4. actinomycosis
  5. amebiasis
  6. anthrax
  7. Bacillus anthracis
  8. Bartonella bacilliformis
  9. bartonellosis
  10. Bordetella pertussis
  11. Borrelia burgdorferi
  12. Borrelia recurrentis
  13. Brucella sp.
  14. brucellosis
  15. Burkholderia mallei
  16. Burkholderia pseudomallei
  17. Campylobacter fetus
  18. Campylobacter fetus infections
  19. cervicitis
  20. chancroid
  21. chlamydia infection
  22. Chlamydia trachomatis
  23. chlamydial conjunctivitis
  24. Chlamydophila psittaci
  25. cholera
  26. clostridial diseases
  27. Clostridium perfringens
  28. Clostridium tetani
  29. Coxiella burnetii
  30. Entamoeba sp.
  31. Escherichia coli
  32. Francisella tularensis
  33. Fusobacterium fusiforme
  34. gonorrhea
  35. granuloma inguinale
  36. Haemophilus ducreyi
  37. Haemophilus influenzae (beta-lactamase negative)
  38. Haemophilus influenzae (beta-lactamase positive)
  39. Klebsiella aerogenes
  40. Klebsiella granulomatis
  41. Klebsiella sp.
  42. Legionella pneumophila
  43. Leptospira sp.
  44. Leptotrichia buccalis
  45. Listeria monocytogenes
  46. listeriosis
  47. lower respiratory tract infections
  48. lymphogranuloma venereum
  49. murine typhus
  50. Mycoplasma hominis
  51. Mycoplasma pneumoniae
  52. necrotizing ulcerative gingivitis
  53. Neisseria gonorrhoeae
  54. Neisseria meningitidis
  55. Nocardia sp.
  56. non-gonococcal urethritis (NGU)
  57. Pasteurella multocida
  58. plague
  59. Propionibacterium acnes
  60. Propionibacterium propionicum
  61. psittacosis
  62. Q fever
  63. relapsing fever
  64. Rickettsia akari
  65. Rickettsia prowazekii
  66. Rickettsia rickettsii
  67. Rickettsia tsutsugamushi
  68. Rickettsial pox
  69. Rocky Mountain spotted fever
  70. Shigella sp.
  71. SIADH
  72. skin and skin structure infections
  73. Spirillum minus
  74. Staphylococcus aureus (MSSA)
  75. Streptobacillus moniliformis
  76. Streptococcus pneumoniae
  77. syphilis
  78. trachoma
  79. Treponema pallidum
  80. Treponema pertenue
  81. tularemia
  82. upper respiratory tract infections
  83. Ureaplasma urealyticum
  84. urethritis
  85. urinary tract infection (UTI)
  86. Vibrio cholerae
  87. Vibrio parahaemolyticus
  88. yaws
  89. Yersinia enterocolitica
  90. Yersinia pestis

Side Effects

  1. anaphylactoid reactions
  2. angioedema
  3. anorexia
  4. arthralgia
  5. azotemia
  6. candidiasis
  7. diabetes insipidus
  8. diarrhea
  9. dizziness
  10. dysphagia
  11. elevated hepatic enzymes
  12. enamel hypoplasia
  13. enterocolitis
  14. eosinophilia
  15. eosinophilic pneumonia
  16. erythema multiforme
  17. esophageal ulceration
  18. esophagitis
  19. glossitis
  20. headache
  21. hemolytic anemia
  22. hepatitis
  23. increased intracranial pressure
  24. lupus-like symptoms
  25. maculopapular rash
  26. myasthenia
  27. nausea
  28. neutropenia
  29. pancreatitis
  30. pericarditis
  31. photosensitivity
  32. polydipsia
  33. polyuria
  34. pseudomembranous colitis
  35. pseudotumor cerebri
  36. renal failure (unspecified)
  37. skin hyperpigmentation
  38. Stevens-Johnson syndrome
  39. superinfection
  40. teratogenesis
  41. thrombocytopenia
  42. tinnitus
  43. tooth discoloration
  44. urticaria
  45. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • children
  • colitis
  • diarrhea
  • driving or operating machinery
  • geriatric
  • GI disease
  • hepatic disease
  • infants
  • inflammatory bowel disease
  • neonates
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • renal failure
  • renal impairment
  • sexually transmitted disease
  • sunlight (UV) exposure
  • tetracyclines hypersensitivity
  • ulcerative colitis

Demeclocycline and other tetracycline antibiotics are contraindicated in patients with known tetracyclines hypersensitivity.

Interactions

  • Acitretin
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amoxicillin
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amoxicillin; Clavulanic Acid
  • Ampicillin
  • Ampicillin; Sulbactam
  • Antacids
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Atracurium
  • Bexarotene
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Calcium
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Chloride
  • Calcium Gluconate
  • Calcium; Vitamin D
  • Carbenicillin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Cholestyramine
  • Chromium
  • Cisatracurium
  • Colesevelam
  • Colestipol
  • Desmopressin
  • Dicloxacillin
  • Didanosine, ddI
  • Dienogest; Estradiol valerate
  • Digoxin
  • Doxacurium
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • food
  • Halobetasol; Tazarotene
  • Heparin
  • Hetastarch; Dextrose; Electrolytes
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Insoluble Prussian Blue
  • Iron
  • Iron Salts
  • Iron Sucrose, Sucroferric Oxyhydroxide
  • Isotretinoin
  • Lanthanum Carbonate
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Lomitapide
  • Magnesium
  • Magnesium Citrate
  • Magnesium Hydroxide
  • Magnesium Salts
  • Mestranol; Norethindrone
  • Methotrexate
  • Methoxsalen
  • Mipomersen
  • Mivacurium
  • Molindone
  • Nafcillin
  • Neuromuscular blockers
  • Norethindrone
  • Norgestrel
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oral Contraceptives
  • Oxacillin
  • Pancuronium
  • Penicillin G
  • Penicillin G Benzathine
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Penicillin V
  • Penicillins
  • Photosensitizing agents (topical)
  • Piperacillin
  • Piperacillin; Tazobactam
  • Polycarbophil
  • Polysaccharide-Iron Complex
  • Porfimer
  • Pyridostigmine
  • Quinapril
  • Rapacuronium
  • Rocuronium
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Bicarbonate
  • Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • St. John’s Wort, Hypericum perforatum
  • Succinylcholine
  • Sucralfate
  • Sulfonylureas
  • Tazarotene
  • Ticarcillin
  • Ticarcillin; Clavulanic Acid
  • Tretinoin, ATRA
  • Tubocurarine
  • Vasopressin, ADH
  • Vecuronium
  • Verteporfin
  • Warfarin
  • Zinc
  • Zinc Salts
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