Demeclocycline Brand Name– Declomycin
What is Demeclocycline
Demeclocycline is a tetracycline antibiotic. It is classified as intermediate in action duration between tetracycline and doxycycline, although this classification scheme is somewhat artificial since tetracycline can be dosed at longer intervals than usually occurs in clinical practice.
Although demeclocycline has activity similar to the other tetracyclines, its main clinical use is to treat inappropriate secretion of ADH secondary to its ability to produce nephrogenic diabetes insipidus.
Photosensitivity is more frequent and more severe with demeclocycline than with other tetracyclines.
Demeclocycline was approved by the FDA in 1960.
Indications
- Acinetobacter sp.
- acne vulgaris
- Actinomyces israelii
- actinomycosis
- amebiasis
- anthrax
- Bacillus anthracis
- Bartonella bacilliformis
- bartonellosis
- Bordetella pertussis
- Borrelia burgdorferi
- Borrelia recurrentis
- Brucella sp.
- brucellosis
- Burkholderia mallei
- Burkholderia pseudomallei
- Campylobacter fetus
- Campylobacter fetus infections
- cervicitis
- chancroid
- chlamydia infection
- Chlamydia trachomatis
- chlamydial conjunctivitis
- Chlamydophila psittaci
- cholera
- clostridial diseases
- Clostridium perfringens
- Clostridium tetani
- Coxiella burnetii
- Entamoeba sp.
- Escherichia coli
- Francisella tularensis
- Fusobacterium fusiforme
- gonorrhea
- granuloma inguinale
- Haemophilus ducreyi
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Klebsiella aerogenes
- Klebsiella granulomatis
- Klebsiella sp.
- Legionella pneumophila
- Leptospira sp.
- Leptotrichia buccalis
- Listeria monocytogenes
- listeriosis
- lower respiratory tract infections
- lymphogranuloma venereum
- murine typhus
- Mycoplasma hominis
- Mycoplasma pneumoniae
- necrotizing ulcerative gingivitis
- Neisseria gonorrhoeae
- Neisseria meningitidis
- Nocardia sp.
- non-gonococcal urethritis (NGU)
- Pasteurella multocida
- plague
- Propionibacterium acnes
- Propionibacterium propionicum
- psittacosis
- Q fever
- relapsing fever
- Rickettsia akari
- Rickettsia prowazekii
- Rickettsia rickettsii
- Rickettsia tsutsugamushi
- Rickettsial pox
- Rocky Mountain spotted fever
- Shigella sp.
- SIADH
- skin and skin structure infections
- Spirillum minus
- Staphylococcus aureus (MSSA)
- Streptobacillus moniliformis
- Streptococcus pneumoniae
- syphilis
- trachoma
- Treponema pallidum
- Treponema pertenue
- tularemia
- upper respiratory tract infections
- Ureaplasma urealyticum
- urethritis
- urinary tract infection (UTI)
- Vibrio cholerae
- Vibrio parahaemolyticus
- yaws
- Yersinia enterocolitica
- Yersinia pestis
Side Effects
- anaphylactoid reactions
- angioedema
- anorexia
- arthralgia
- azotemia
- candidiasis
- diabetes insipidus
- diarrhea
- dizziness
- dysphagia
- elevated hepatic enzymes
- enamel hypoplasia
- enterocolitis
- eosinophilia
- eosinophilic pneumonia
- erythema multiforme
- esophageal ulceration
- esophagitis
- glossitis
- headache
- hemolytic anemia
- hepatitis
- increased intracranial pressure
- lupus-like symptoms
- maculopapular rash
- myasthenia
- nausea
- neutropenia
- pancreatitis
- pericarditis
- photosensitivity
- polydipsia
- polyuria
- pseudomembranous colitis
- pseudotumor cerebri
- renal failure (unspecified)
- skin hyperpigmentation
- Stevens-Johnson syndrome
- superinfection
- teratogenesis
- thrombocytopenia
- tinnitus
- tooth discoloration
- urticaria
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- breast-feeding
- children
- colitis
- diarrhea
- driving or operating machinery
- geriatric
- GI disease
- hepatic disease
- infants
- inflammatory bowel disease
- neonates
- pregnancy
- pseudomembranous colitis
- renal disease
- renal failure
- renal impairment
- sexually transmitted disease
- sunlight (UV) exposure
- tetracyclines hypersensitivity
- ulcerative colitis
Demeclocycline and other tetracycline antibiotics are contraindicated in patients with known tetracyclines hypersensitivity.
Interactions
- Acitretin
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amoxicillin
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amoxicillin; Clavulanic Acid
- Ampicillin
- Ampicillin; Sulbactam
- Antacids
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Atracurium
- Bexarotene
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Calcium
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Chloride
- Calcium Gluconate
- Calcium; Vitamin D
- Carbenicillin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Cholestyramine
- Chromium
- Cisatracurium
- Colesevelam
- Colestipol
- Desmopressin
- Dicloxacillin
- Didanosine, ddI
- Dienogest; Estradiol valerate
- Digoxin
- Doxacurium
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- food
- Halobetasol; Tazarotene
- Heparin
- Hetastarch; Dextrose; Electrolytes
- Hydrochlorothiazide, HCTZ; Quinapril
- Insoluble Prussian Blue
- Iron
- Iron Salts
- Iron Sucrose, Sucroferric Oxyhydroxide
- Isotretinoin
- Lanthanum Carbonate
- Leuprolide; Norethindrone
- Levonorgestrel
- Lomitapide
- Magnesium
- Magnesium Citrate
- Magnesium Hydroxide
- Magnesium Salts
- Mestranol; Norethindrone
- Methotrexate
- Methoxsalen
- Mipomersen
- Mivacurium
- Molindone
- Nafcillin
- Neuromuscular blockers
- Norethindrone
- Norgestrel
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oral Contraceptives
- Oxacillin
- Pancuronium
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Penicillin V
- Penicillins
- Photosensitizing agents (topical)
- Piperacillin
- Piperacillin; Tazobactam
- Polycarbophil
- Polysaccharide-Iron Complex
- Porfimer
- Pyridostigmine
- Quinapril
- Rapacuronium
- Rocuronium
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Bicarbonate
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- St. John’s Wort, Hypericum perforatum
- Succinylcholine
- Sucralfate
- Sulfonylureas
- Tazarotene
- Ticarcillin
- Ticarcillin; Clavulanic Acid
- Tretinoin, ATRA
- Tubocurarine
- Vasopressin, ADH
- Vecuronium
- Verteporfin
- Warfarin
- Zinc
- Zinc Salts