Defibrotide Brand Name– Defitelio
What is Defibrotide
Defibrotide is indicated for the treatment of hepatic veno-occlusive disease (VOD), also called sinusoidal obstructive syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT) in adult and pediatric patients. Untreated hepatic VOD/SOS with multi-organ failure is associated with more than 80% mortality.
Defibrotide has been shown to improve survival in patients with established VOD/SOS with multi-organ failure at day +100 after HSCT. Because of increased risk of bleeding, defibrotide is contraindicated with concomitant, systemic antithrombotic or antifibrinolytic therapies.
Defibrotide was FDA-approved in March 2016.
Indications
- sinusoidal obstruction syndrome (SOS)
- veno-occlusive disease (VOD)
For the treatment of hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), with renal or pulmonary dysfunction following hematopoietic stem-cell transplantation (HSCT)
Side Effects
- anaphylactoid reactions
- angioedema
- bleeding
- diarrhea
- epistaxis
- GI bleeding
- GI bleeding
- graft-versus-host disease (GVHD)
- hyperuricemia
- hypotension
- hypotension
- infection
- infection
- intracranial bleeding
- intracranial bleeding
- nausea
- rash
- urticaria
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- anticoagulant therapy
- bleeding
- breast-feeding
- pregnancy
- surgery
Interactions
- Abciximab
- Acetaminophen; Aspirin, ASA; Caffeine
- Alteplase
- Anagrelide
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Betrixaban
- Bivalirudin
- Cangrelor
- Cilostazol
- Clopidogrel
- Dabigatran
- Dalteparin
- Danaparoid
- Desirudin
- Dipyridamole
- Edoxaban
- Enoxaparin
- Eptifibatide
- Fondaparinux
- Heparin
- Lepirudin
- Pentosan
- Platelet Inhibitors
- Prasugrel
- Reteplase, r-PA
- Rivaroxaban
- Streptokinase
- Tenecteplase
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Tinzaparin
- Tirofiban
- Urokinase
- Vorapaxar
- Warfarin
