Decitabine Brand Name– Dacogen
What is Decitabine
Decitabine is a pyrimidine antimetabolite. It is indicated for the treatment of adult patients with myelodysplastic syndrome.
Severe myelosuppression has been reported with decitabine therapy; monitor complete blood counts during therapy
Indications
- acute myelogenous leukemia (AML)
- chronic myelogenous leukemia (CML)
- myelodysplastic syndrome (MDS)
For the treatment myelodysplastic syndrome (MDS)
NOTE: Decitabine is designated an orphan drug by the FDA for the treatment of MDS.
for the treatment of previously treated or untreated and de novo or secondary MDS including all French-American-British subtypes and intermediate-1, intermediate-2, and high-risk International Prognostic Scoring System groups
Side Effects
- abdominal pain
- alopecia
- anaphylactoid reactions
- anemia
- anorexia
- anxiety
- arthralgia
- ascites
- asthenia
- atrial fibrillation
- back pain
- blurred vision
- bone pain
- candidiasis
- cardiac arrest
- cardiomyopathy
- chest pain (unspecified)
- chills
- cholecystitis
- confusion
- constipation
- cough
- dehydration
- depression
- diarrhea
- differentiation syndrome
- dizziness
- dyspepsia
- dysphagia
- dyspnea
- dysuria
- ecchymosis
- edema
- elevated hepatic enzymes
- epistaxis
- erythema
- fatigue
- fever
- gastroesophageal reflux
- GI bleeding
- headache
- heart failure
- hematoma
- hemoptysis
- hemorrhoids
- hyperbilirubinemia
- hyperglycemia
- hyperkalemia
- hypertension
- hypoalbuminemia
- hypochloremia
- hypoesthesia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypotension
- hypoxia
- increased urinary frequency
- infection
- injection site reaction
- insomnia
- intracranial bleeding
- lethargy
- leukopenia
- lymphadenopathy
- malaise
- metabolic acidosis
- metabolic alkalosis
- musculoskeletal pain
- myalgia
- myocardial infarction
- nasal congestion
- nausea
- neutropenia
- neutropenia
- night sweats
- oral ulceration
- otalgia
- pancytopenia
- peripheral edema
- petechiae
- pharyngitis
- pleural effusion
- pruritus
- pulmonary edema
- pulmonary embolism
- rash
- renal failure (unspecified)
- respiratory arrest
- sinus tachycardia
- sinusitis
- splenomegaly
- stomatitis
- supraventricular tachycardia (SVT)
- thrombocytopenia
- thrombocytopenia
- urticaria
- vomiting
- weakness
- weight loss
- xerosis
Monitoring Parameters
- CBC with differential
- LFTs
- pregnancy testing
- serum creatinine/BUN
Contraindications
- anemia
- bone marrow suppression
- breast-feeding
- contraception requirements
- hepatic disease
- infection
- infertility
- male-mediated teratogenicity
- neutropenia
- pregnancy
- pregnancy testing
- renal disease
- reproductive risk
- thrombocytopenia
Interactions
- Amlodipine; Celecoxib
- Anticoagulants
- Antithrombin III
- Apixaban
- Argatroban
- Betrixaban
- Bivalirudin
- Celecoxib
- Dabigatran
- Dalteparin
- Danaparoid
- Desirudin
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Edoxaban
- Enoxaparin
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Flurbiprofen
- Fondaparinux
- Heparin
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lepirudin
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Palifermin
- Penicillamine
- Pentosan
- Piroxicam
- Rivaroxaban
- Rofecoxib
- Sulindac
- Tinzaparin
- Tolmetin
- Tuberculin Purified Protein Derivative, PPD
- Valdecoxib
- Warfarin
