Daunorubicin Liposomal Cytarabine Liposomal

Daunorubicin Liposomal Cytarabine Liposomal Brand Name– VYXEOS

What is Daunorubicin Liposomal Cytarabine Liposomal

Daunorubicin liposomal cytarabine liposomal is a combination of daunorubicin and cytarabine in a 1:5 molar ratio encapsulated in liposomes. It is approved for the treatment of adult patients with newly diagnosed therapy-related AML or AML with myelodysplasia-related changes.

Daunorubicin liposomal cytarabine liposomal has different dosage recommendations than daunorubicin hydrochloride injection, cytarabine injection, daunorubicin citrate liposome injection, and cytarabine liposome injection; therefore, do not interchange the daunorubicin/cytarabine liposomal formulation with other daunorubicin- or cytarabine-containing products. Severe and life-threatening bleeding events and hypersensitivity reactions have been reported.

Indications

  • acute myelogenous leukemia (AML)

For the treatment of acute myelogenous leukemia (AML)

NOTE: Daunorubicin liposomal;cytarabine liposomal has been designated as an orphan drug by the FDA for the treatment of AML.

for the treatment of newly diagnosed therapy-related AML or AML with myelodysplasia-related changes

Side Effects

  1. abdominal pain
  2. abdominal pain
  3. abnormal dreams
  4. abnormal dreams
  5. acute respiratory distress syndrome (ARDS)
  6. anaphylactoid reactions
  7. anemia
  8. angina
  9. angina
  10. anorexia
  11. anorexia
  12. anxiety
  13. apnea
  14. arthralgia
  15. arthralgia
  16. asthenia
  17. asthenia
  18. atopic dermatitis
  19. atopic dermatitis
  20. atrial fibrillation
  21. atrial flutter
  22. atrial tachycardia
  23. AV block
  24. azotemia
  25. back pain
  26. back pain
  27. bleeding
  28. bleeding
  29. blurred vision
  30. bone pain
  31. bone pain
  32. bradycardia
  33. bronchospasm
  34. bundle-branch block
  35. bundle-branch block
  36. candidiasis
  37. candidiasis
  38. cardiac arrest
  39. cardiomyopathy
  40. cardiotoxicity
  41. chest pain (unspecified)
  42. chest pain (unspecified)
  43. chills
  44. coagulopathy
  45. colitis
  46. colitis
  47. confusion
  48. confusion
  49. conjunctivitis
  50. constipation
  51. contact dermatitis
  52. contact dermatitis
  53. copper toxicity
  54. cough
  55. delirium
  56. delirium
  57. diarrhea
  58. diarrhea
  59. dizziness
  60. dizziness
  61. dyspepsia
  62. dyspnea
  63. dyspnea
  64. ecchymosis
  65. edema
  66. edema
  67. elevated hepatic enzymes
  68. enterocolitis
  69. epistaxis
  70. erythema nodosum
  71. esophageal ulceration
  72. esophagitis
  73. esophagitis
  74. fatigue
  75. fatigue
  76. fever
  77. fever
  78. fluid retention
  79. fluid retention
  80. GI bleeding
  81. gingivitis
  82. gingivitis
  83. hallucinations
  84. headache
  85. headache
  86. hearing loss
  87. heart failure
  88. hematemesis
  89. hematoma
  90. hematuria
  91. hemoptysis
  92. hemorrhoids
  93. hyperbilirubinemia
  94. hyperemia
  95. hypertension
  96. hypertension
  97. hypoalbuminemia
  98. hypokalemia
  99. hyponatremia
  100. hypotension
  101. hypotension
  102. hypoxia
  103. hypoxia
  104. impaired cognition
  105. impaired cognition
  106. infection
  107. infection
  108. infusion-related reactions
  109. injection site reaction
  110. insomnia
  111. insomnia
  112. intracranial bleeding
  113. maculopapular rash
  114. maculopapular rash
  115. melena
  116. musculoskeletal pain
  117. musculoskeletal pain
  118. myalgia
  119. myalgia
  120. myocardial infarction
  121. nasal congestion
  122. nasal congestion
  123. nausea
  124. nausea
  125. nephrotoxicity
  126. neutropenia
  127. nightmares
  128. nightmares
  129. ocular irritation
  130. ocular pain
  131. odynophagia
  132. oliguria
  133. oral ulceration
  134. oral ulceration
  135. orthostatic hypotension
  136. orthostatic hypotension
  137. penile edema
  138. peptic ulcer
  139. pericardial effusion
  140. pericarditis
  141. peripheral edema
  142. peripheral edema
  143. petechiae
  144. pharyngitis
  145. pharyngitis
  146. photophobia
  147. photopsia
  148. photosensitivity
  149. pleural effusion
  150. pneumonitis
  151. proctitis
  152. proctitis
  153. pruritus
  154. psoriasis
  155. psoriasis
  156. purpura
  157. rash
  158. rash
  159. renal failure (unspecified)
  160. retinal hemorrhage
  161. rhinitis
  162. rhinitis
  163. rhinorrhea
  164. rhinorrhea
  165. sinus tachycardia
  166. sinus tachycardia
  167. sinusitis
  168. sinusitis
  169. stomatitis
  170. stomatitis
  171. subdural hematoma
  172. supraventricular tachycardia (SVT)
  173. supraventricular tachycardia (SVT)
  174. thrombocytopenia
  175. uveitis
  176. vaginal bleeding
  177. visual impairment
  178. vomiting
  179. wheezing
  180. wheezing
  181. xerophthalmia

Monitoring Parameters

  • CBC with differential
  • ECG
  • echocardiogram
  • LFTs
  • multi-gated radionuclide angiography (MUGA)
  • pregnancy testing
  • serum creatinine/BUN

Contraindications

  • anthracycline hypersensitivity
  • bleeding
  • breast-feeding
  • cardiac disease
  • cardiotoxicity
  • contraception requirements
  • ensure correct formulation selection
  • extravasation
  • geriatric
  • heart failure
  • hepatic disease
  • hepatotoxicity
  • infertility
  • infusion-related reactions
  • intracranial bleeding
  • intramuscular administration
  • male-mediated teratogenicity
  • neutropenia
  • pregnancy
  • pregnancy testing
  • radiation therapy
  • renal disease
  • renal failure
  • renal impairment
  • reproductive risk
  • subcutaneous administration
  • Wilson’s disease

Interactions

  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Cyclophosphamide
  • Cyclosporine
  • Digoxin
  • Glecaprevir; Pibrentasvir
  • Lumacaftor; Ivacaftor
  • Palifermin
  • Penicillamine
  • Tuberculin Purified Protein Derivative, PPD
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