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Daunorubicin Liposomal Cytarabine Liposomal Brand Name– VYXEOS
What is Daunorubicin Liposomal Cytarabine Liposomal
Daunorubicin liposomal cytarabine liposomal is a combination of daunorubicin and cytarabine in a 1:5 molar ratio encapsulated in liposomes. It is approved for the treatment of adult patients with newly diagnosed therapy-related AML or AML with myelodysplasia-related changes.
Daunorubicin liposomal cytarabine liposomal has different dosage recommendations than daunorubicin hydrochloride injection, cytarabine injection, daunorubicin citrate liposome injection, and cytarabine liposome injection; therefore, do not interchange the daunorubicin/cytarabine liposomal formulation with other daunorubicin- or cytarabine-containing products. Severe and life-threatening bleeding events and hypersensitivity reactions have been reported.
Indications
- acute myelogenous leukemia (AML)
For the treatment of acute myelogenous leukemia (AML)
NOTE: Daunorubicin liposomal;cytarabine liposomal has been designated as an orphan drug by the FDA for the treatment of AML.
for the treatment of newly diagnosed therapy-related AML or AML with myelodysplasia-related changes
Side Effects
- abdominal pain
- abdominal pain
- abnormal dreams
- abnormal dreams
- acute respiratory distress syndrome (ARDS)
- anaphylactoid reactions
- anemia
- angina
- angina
- anorexia
- anorexia
- anxiety
- apnea
- arthralgia
- arthralgia
- asthenia
- asthenia
- atopic dermatitis
- atopic dermatitis
- atrial fibrillation
- atrial flutter
- atrial tachycardia
- AV block
- azotemia
- back pain
- back pain
- bleeding
- bleeding
- blurred vision
- bone pain
- bone pain
- bradycardia
- bronchospasm
- bundle-branch block
- bundle-branch block
- candidiasis
- candidiasis
- cardiac arrest
- cardiomyopathy
- cardiotoxicity
- chest pain (unspecified)
- chest pain (unspecified)
- chills
- coagulopathy
- colitis
- colitis
- confusion
- confusion
- conjunctivitis
- constipation
- contact dermatitis
- contact dermatitis
- copper toxicity
- cough
- delirium
- delirium
- diarrhea
- diarrhea
- dizziness
- dizziness
- dyspepsia
- dyspnea
- dyspnea
- ecchymosis
- edema
- edema
- elevated hepatic enzymes
- enterocolitis
- epistaxis
- erythema nodosum
- esophageal ulceration
- esophagitis
- esophagitis
- fatigue
- fatigue
- fever
- fever
- fluid retention
- fluid retention
- GI bleeding
- gingivitis
- gingivitis
- hallucinations
- headache
- headache
- hearing loss
- heart failure
- hematemesis
- hematoma
- hematuria
- hemoptysis
- hemorrhoids
- hyperbilirubinemia
- hyperemia
- hypertension
- hypertension
- hypoalbuminemia
- hypokalemia
- hyponatremia
- hypotension
- hypotension
- hypoxia
- hypoxia
- impaired cognition
- impaired cognition
- infection
- infection
- infusion-related reactions
- injection site reaction
- insomnia
- insomnia
- intracranial bleeding
- maculopapular rash
- maculopapular rash
- melena
- musculoskeletal pain
- musculoskeletal pain
- myalgia
- myalgia
- myocardial infarction
- nasal congestion
- nasal congestion
- nausea
- nausea
- nephrotoxicity
- neutropenia
- nightmares
- nightmares
- ocular irritation
- ocular pain
- odynophagia
- oliguria
- oral ulceration
- oral ulceration
- orthostatic hypotension
- orthostatic hypotension
- penile edema
- peptic ulcer
- pericardial effusion
- pericarditis
- peripheral edema
- peripheral edema
- petechiae
- pharyngitis
- pharyngitis
- photophobia
- photopsia
- photosensitivity
- pleural effusion
- pneumonitis
- proctitis
- proctitis
- pruritus
- psoriasis
- psoriasis
- purpura
- rash
- rash
- renal failure (unspecified)
- retinal hemorrhage
- rhinitis
- rhinitis
- rhinorrhea
- rhinorrhea
- sinus tachycardia
- sinus tachycardia
- sinusitis
- sinusitis
- stomatitis
- stomatitis
- subdural hematoma
- supraventricular tachycardia (SVT)
- supraventricular tachycardia (SVT)
- thrombocytopenia
- uveitis
- vaginal bleeding
- visual impairment
- vomiting
- wheezing
- wheezing
- xerophthalmia
Monitoring Parameters
- CBC with differential
- ECG
- echocardiogram
- LFTs
- multi-gated radionuclide angiography (MUGA)
- pregnancy testing
- serum creatinine/BUN
Contraindications
- anthracycline hypersensitivity
- bleeding
- breast-feeding
- cardiac disease
- cardiotoxicity
- contraception requirements
- ensure correct formulation selection
- extravasation
- geriatric
- heart failure
- hepatic disease
- hepatotoxicity
- infertility
- infusion-related reactions
- intracranial bleeding
- intramuscular administration
- male-mediated teratogenicity
- neutropenia
- pregnancy
- pregnancy testing
- radiation therapy
- renal disease
- renal failure
- renal impairment
- reproductive risk
- subcutaneous administration
- Wilson’s disease
Interactions
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Cyclophosphamide
- Cyclosporine
- Digoxin
- Glecaprevir; Pibrentasvir
- Lumacaftor; Ivacaftor
- Palifermin
- Penicillamine
- Tuberculin Purified Protein Derivative, PPD
