Dalbavancin Brand Name– DALVANCE
What is Dalbavancin
Dalbavancin is a second-generation glycopeptide antibiotic approved for the treatment of acute bacterial skin and skin structure infections (ABSSSI) caused by certain susceptible bacteria like Staphylococcus aureus (including methicillin-susceptible and methicillin-resistant strains) and Streptococcus pyogenes.
Glycopeptides inhibit bacterial cell wall synthesis by blocking the transglycosylation step of peptidoglycan biosynthesis by interfering with substrate utilization.
They interact with dipeptidyl residues of peptidoglycan precursors.
Two clinical trials demonstrated that dalbavancin was as effective as vancomycin for the treatment of ABSSSI.
Due to an extended half-life, dalbavancin is dosed as weekly intervals.
Unlike vancomycin, dosing is not guided by routine serum concentration measurement.
The most common adverse effects observed in clinical trials were nausea, headache, and diarrhea.
Dalbavancin was FDA-approved in May 2014.
Indications
- cellulitis
- Enterococcus faecalis
- Enterococcus faecium
- skin and skin structure infections
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Streptococcus agalactiae (group B streptococci)
- Streptococcus anginosus
- Streptococcus constellatus
- Streptococcus dysgalactiae
- Streptococcus intermedius
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
Side Effects
- abdominal pain
- anaphylactoid reactions
- anemia
- back pain
- bronchospasm
- candidiasis
- diarrhea
- dizziness
- elevated hepatic enzymes
- eosinophilia
- flushing
- GI bleeding
- headache
- hematoma
- hypoglycemia
- infusion-related reactions
- leukopenia
- melena
- nausea
- neutropenia
- petechiae
- phlebitis
- pruritus
- pseudomembranous colitis
- rash
- red man syndrome
- thrombocytopenia
- thrombocytosis
- urticaria
- vomiting
Monitoring Parameters
- CBC with differential
- LFTs
- serum creatinine/BUN
Contraindications
- antimicrobial resistance
- breast-feeding
- colitis
- diarrhea
- geriatric
- GI disease
- inflammatory bowel disease
- infusion-related reactions
- pregnancy
- pseudomembranous colitis
- renal impairment
- ulcerative colitis
- vancomycin hypersensitivity
- viral infection
Interactions
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Leuprolide; Norethindrone
- Levonorgestrel
- Mestranol; Norethindrone
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Segesterone Acetate; Ethinyl Estradiol
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
