Colestipol Brand Name– Colestid
What is Colestipol
Colestipol hydrochloride is an oral antilipemic agent. It is a nonabsorbable bile acid sequestrant similar in action to cholestyramine. Colestipol and cholestyramine appear to be equal in their cholesterol-lowering effects.
Since the development and release of HMG-CoA-reductase inhibitors, colestipol use has declined.
Colestipol, however, is not absorbed and has a safer toxicity profile than do other antilipemics, thus making it a desirable agent in children and pregnant women.
Colestipol was approved by the FDA in 1977.
In May 1994, Pharmacia & Upjohn applied to the FDA to allow OTC sale of Colestid(R), however in October 1997, the FDA voted to not allow OTC of drugs for the treatment of hypercholesterolemia.
Indications
- diarrhea
- digitoxin overdose
- digitoxin toxicity
- digoxin overdose
- hypercholesterolemia
- hyperlipoproteinemia
- pruritus
For the treatment of primary hypercholesterolemia (elevated LDL cholesterol hyperlipoproteinemia) in conjunction with dietary control in patients with hypertriglyceridemia; for the treatment of diarrhea† due to increased bile acids after surgery; for the treatment of pruritus† associated with partial biliary obstruction
Side Effects
- abdominal pain
- angina
- anorexia
- arthralgia
- back pain
- chest pain (unspecified)
- cholestasis
- constipation
- diarrhea
- dizziness
- dysphagia
- dyspnea
- edema
- elevated hepatic enzymes
- eructation
- fatigue
- flatulence
- folate deficiency
- GI bleeding
- headache
- hemorrhoids
- hypoprothrombinemia
- insomnia
- migraine
- musculoskeletal pain
- nausea
- peptic ulcer
- rash
- sinus tachycardia
- urticaria
- vomiting
- weakness
Monitoring Parameters
- LFTs
- serum creatinine/BUN
Contraindications
- biliary cirrhosis
- biliary obstruction
- breast-feeding
- children
- cholelithiasis
- coagulopathy
- constipation
- dysphagia
- GI obstruction
- hemorrhoids
- hypertriglyceridemia
- hypothyroidism
- ileus
- phenylketonuria
- pregnancy
- renal disease
Interactions
- Alendronate; Cholecalciferol
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alpha-glucosidase Inhibitors
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Atorvastatin
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Aspirin, ASA; Pravastatin
- Atenolol; Chlorthalidone
- Atorvastatin
- Atorvastatin; Ezetimibe
- Azilsartan; Chlorthalidone
- Bempedoic Acid; Ezetimibe
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Bexarotene
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Calcifediol
- Calcitriol
- Calcium; Vitamin D
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Chenodiol
- Chlorothiazide
- Chlorthalidone
- Chlorthalidone; Clonidine
- Cholic Acid
- Cranberry, Vaccinium macrocarpon Ait.
- Deferasirox
- Diclofenac
- Diclofenac; Misoprostol
- Digoxin
- Dihydrotachysterol
- Doxercalciferol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Enalapril; Hydrochlorothiazide, HCTZ
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ergocalciferol, Vitamin D2
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ezetimibe
- Ezetimibe; Simvastatin
- Fat soluble vitamins
- Fenofibrate
- Fenofibric Acid
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
- Gemfibrozil
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocortisone
- Ibritumomab Tiuxetan
- Isotretinoin
- Levomefolate
- Lomitapide
- Lovastatin; Niacin
- Methyclothiazide
- Metolazone
- Mycophenolate
- Niacin, Niacinamide
- Niacin; Simvastatin
- Obeticholic Acid
- Paricalcitol
- Penicillin G
- Penicillin G Benzathine
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Phosphorated Carbohydrate Solution
- Phosphorus
- Phytonadione, Vitamin K1
- Potassium Phosphate
- Potassium Phosphate; Sodium Phosphate
- Pravastatin
- Propranolol
- Tetracyclines
- Thiazide diuretics
- Thyroid hormones
- Tretinoin, ATRA
- Ursodeoxycholic Acid, Ursodiol
- Vancomycin
- Vitamin A
- Vitamin E
- Warfarin