Colestipol

Colestipol Brand Name– Colestid

What is Colestipol

Colestipol hydrochloride is an oral antilipemic agent. It is a nonabsorbable bile acid sequestrant similar in action to cholestyramine. Colestipol and cholestyramine appear to be equal in their cholesterol-lowering effects.

Since the development and release of HMG-CoA-reductase inhibitors, colestipol use has declined.

Colestipol, however, is not absorbed and has a safer toxicity profile than do other antilipemics, thus making it a desirable agent in children and pregnant women.

Colestipol was approved by the FDA in 1977.

In May 1994, Pharmacia & Upjohn applied to the FDA to allow OTC sale of Colestid(R), however in October 1997, the FDA voted to not allow OTC of drugs for the treatment of hypercholesterolemia.

Indications

  1. diarrhea
  2. digitoxin overdose
  3. digitoxin toxicity
  4. digoxin overdose
  5. hypercholesterolemia
  6. hyperlipoproteinemia
  7. pruritus

For the treatment of primary hypercholesterolemia (elevated LDL cholesterol hyperlipoproteinemia) in conjunction with dietary control in patients with hypertriglyceridemia; for the treatment of diarrhea† due to increased bile acids after surgery; for the treatment of pruritus† associated with partial biliary obstruction

Side Effects

  1. abdominal pain
  2. angina
  3. anorexia
  4. arthralgia
  5. back pain
  6. chest pain (unspecified)
  7. cholestasis
  8. constipation
  9. diarrhea
  10. dizziness
  11. dysphagia
  12. dyspnea
  13. edema
  14. elevated hepatic enzymes
  15. eructation
  16. fatigue
  17. flatulence
  18. folate deficiency
  19. GI bleeding
  20. headache
  21. hemorrhoids
  22. hypoprothrombinemia
  23. insomnia
  24. migraine
  25. musculoskeletal pain
  26. nausea
  27. peptic ulcer
  28. rash
  29. sinus tachycardia
  30. urticaria
  31. vomiting
  32. weakness

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN

Contraindications

  • biliary cirrhosis
  • biliary obstruction
  • breast-feeding
  • children
  • cholelithiasis
  • coagulopathy
  • constipation
  • dysphagia
  • GI obstruction
  • hemorrhoids
  • hypertriglyceridemia
  • hypothyroidism
  • ileus
  • phenylketonuria
  • pregnancy
  • renal disease

Interactions

  • Alendronate; Cholecalciferol
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alpha-glucosidase Inhibitors
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Atorvastatin
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Aspirin, ASA; Pravastatin
  • Atenolol; Chlorthalidone
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Azilsartan; Chlorthalidone
  • Bempedoic Acid; Ezetimibe
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Bexarotene
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Calcifediol
  • Calcitriol
  • Calcium; Vitamin D
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Chenodiol
  • Chlorothiazide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Cholic Acid
  • Cranberry, Vaccinium macrocarpon Ait.
  • Deferasirox
  • Diclofenac
  • Diclofenac; Misoprostol
  • Digoxin
  • Dihydrotachysterol
  • Doxercalciferol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergocalciferol, Vitamin D2
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ezetimibe
  • Ezetimibe; Simvastatin
  • Fat soluble vitamins
  • Fenofibrate
  • Fenofibric Acid
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Furosemide
  • Gemfibrozil
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocortisone
  • Ibritumomab Tiuxetan
  • Isotretinoin
  • Levomefolate
  • Lomitapide
  • Lovastatin; Niacin
  • Methyclothiazide
  • Metolazone
  • Mycophenolate
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Obeticholic Acid
  • Paricalcitol
  • Penicillin G
  • Penicillin G Benzathine
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Phosphorated Carbohydrate Solution
  • Phosphorus
  • Phytonadione, Vitamin K1
  • Potassium Phosphate
  • Potassium Phosphate; Sodium Phosphate
  • Pravastatin
  • Propranolol
  • Tetracyclines
  • Thiazide diuretics
  • Thyroid hormones
  • Tretinoin, ATRA
  • Ursodeoxycholic Acid, Ursodiol
  • Vancomycin
  • Vitamin A
  • Vitamin E
  • Warfarin
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