Bempedoic Acid

Bempedoic Acid Brand Name– NEXLETOL

What is Bempedoic Acid

Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor approved as an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease in adults who require additional lowering of LDL-C.

Bempedoic acid is an inactive prodrug that requires coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1).

Since ACSVL1 is primarily located in the liver and not in adipose tissue or muscle, it is theorized to have reduced adverse effects, such as myotoxicity, due to minimal exposure to non-hepatic tissues.

Indications

  • atherosclerosis
  • heterozygous familial hypercholesterolemia

For use as an adjunct to diet and maximally tolerated statin therapy in the treatment of heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease (atherosclerosis) to reduce low-density lipoprotein cholesterol (LDL-C)

Side Effects

  1. abdominal pain
  2. anemia
  3. atrial fibrillation
  4. back pain
  5. diarrhea
  6. elevated hepatic enzymes
  7. gout
  8. hyperuricemia
  9. infection
  10. leukopenia
  11. muscle cramps
  12. prostatic hypertrophy
  13. tendon rupture
  14. thrombocytosis

Monitoring Parameters

  • serum lipid profile

Contraindications

  • breast-feeding
  • corticosteroid therapy
  • gout
  • hyperuricemia
  • pregnancy
  • renal failure
  • tendon rupture

Interactions

  • Aspirin, ASA; Pravastatin
  • Ezetimibe; Simvastatin
  • Niacin; Simvastatin
  • Pravastatin
  • Simvastatin
  • Simvastatin; Sitagliptin
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