Ciprofloxacin Dexamethasone

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Ciprofloxacin Dexamethasone Brand Name– Ciprodex Otic

What is Ciprofloxacin Dexamethasone

Ciprofloxacin dexamethasone otic suspension is used for the topical treatment of selected ear infections.

The combination is useful for middle ear infections (acute otitis media, AOM) due to susceptible organisms (e.g., Pseudomonas aeruginosaStaphylococcus aureus) in children with tympanostomy tubes aged 6 months and older.

The combination is also used for the topical treatment of acute otitis externa (AOE) (e.g., swimmer’s ear) in pediatric, adult, and elderly patients.

Ciprofloxacin is a fluoroquinolone antibiotic with in vitro activity against a wide range of gram-positive and gram-negative microorganisms; topical use in the ear is not associated with ototoxicity.

Dexamethasone is an anti-inflammatory corticosteroid and is included to aid in the resolution of the inflammatory response associated with the bacterial infection.

The FDA approved ciprofloxacin;dexamethasone otic suspension (Ciprodex® Otic) on July 18, 2003.

Indications

  1. Haemophilus influenzae (beta-lactamase negative)
  2. Haemophilus influenzae (beta-lactamase positive)
  3. Moraxella catarrhalis
  4. otitis externa
  5. otitis media
  6. Pseudomonas aeruginosa
  7. Staphylococcus aureus (MSSA)
  8. Streptococcus pneumoniae

Side Effects

  1. antimicrobial resistance
  2. candidiasis
  3. dizziness
  4. dysgeusia
  5. erythema
  6. headache
  7. hearing loss
  8. irritability
  9. otalgia
  10. pruritus
  11. tinnitus
  12. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • corticosteroid hypersensitivity
  • ear discharge
  • fungal infection
  • herpes infection
  • infants
  • mycobacterial infection
  • neonates
  • ophthalmic administration
  • parenteral administration
  • pregnancy
  • quinolone hypersensitivity
  • varicella
  • viral infection

Interactions

There are no drug interactions associated with Ciprofloxacin; Dexamethasone products.

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