Cholestyramine

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Cholestyramine Brand Names

Locholest | Locholest Light | Prevalite | Questran | Questran Light

What is Cholestyramine

Cholestyramine is a polymeric resin, administered orally to bind bile acids. Originally, cholestyramine was used to treat pruritis secondary to cholestasis, but its main use today is to treat hypercholesterolemia with concomitant hypertriglyceridemia.

Cholestyramine also has been used to treat Clostridium difficile enterocolitis, although traditional antibiotics are more effective. Since cholestyramine and the related agent colestipol are not absorbed orally, they are the drugs of choice for treating hyperlipidemia in pregnant women.

Cholestyramine was approved by the FDA in 1966.

A request for OTC status has been considered and denied twice by the FDA: once in October 1995 and again in May 1997.

Indications

  1. diarrhea
  2. hypercholesterolemia
  3. hyperlipoproteinemia
  4. pruritus

For treatment of hypercholesterolemia, especially elevated LDL cholesterol (type IIa and IIb hyperlipoproteinemia), and for pruritus associated with biliary stasis

Side Effects

  1. abdominal pain
  2. anemia
  3. anorexia
  4. anxiety
  5. back pain
  6. cholelithiasis
  7. colic
  8. constipation
  9. dental caries
  10. diarrhea
  11. diuresis
  12. dizziness
  13. drowsiness
  14. dysgeusia
  15. dyspepsia
  16. dysphagia
  17. dyspnea
  18. dysuria
  19. ecchymosis
  20. edema
  21. elevated hepatic enzymes
  22. eructation
  23. fatigue
  24. flatulence
  25. folate deficiency
  26. GI bleeding
  27. GI obstruction
  28. headache
  29. hematuria
  30. hiccups
  31. hyperchloremic acidosis
  32. hypoprothrombinemia
  33. libido increase
  34. musculoskeletal pain
  35. nausea
  36. neuropathic pain
  37. night blindness
  38. osteoporosis
  39. pancreatitis
  40. paresthesias
  41. peptic ulcer
  42. prolonged bleeding time
  43. rash
  44. skin irritation
  45. steatorrhea
  46. stool discoloration
  47. syncope
  48. tinnitus
  49. tooth discoloration
  50. urticaria
  51. uveitis
  52. vertigo
  53. vomiting
  54. weight gain
  55. weight loss
  56. wheezing

Monitoring Parameters

  • serum lipid profile

Contraindications

  • biliary cirrhosis
  • biliary obstruction
  • breast-feeding
  • children
  • cholelithiasis
  • coagulopathy
  • constipation
  • dysphagia
  • geriatric
  • GI obstruction
  • hemorrhoids
  • hypertriglyceridemia
  • hypothyroidism
  • ileus
  • phenylketonuria
  • pregnancy
  • renal disease

Interactions

  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Alendronate; Cholecalciferol
  • Alpha-glucosidase Inhibitors
  • Amiodarone
  • Aspirin, ASA; Pravastatin
  • Atorvastatin; Ezetimibe
  • Bempedoic Acid; Ezetimibe
  • Benzhydrocodone; Acetaminophen
  • Bexarotene
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Calcifediol
  • Calcitriol
  • Calcium; Vitamin D
  • Carbidopa; Levodopa; Entacapone
  • Cephalexin
  • Chenodiol
  • Cholic Acid
  • Cranberry, Vaccinium macrocarpon Ait.
  • Deferasirox
  • Dexamethasone
  • Diclofenac
  • Diclofenac; Misoprostol
  • Digoxin
  • Dihydrotachysterol
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Doxercalciferol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Entacapone
  • Ergocalciferol, Vitamin D2
  • Esomeprazole; Naproxen
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ezetimibe
  • Ezetimibe; Simvastatin
  • Famotidine; Ibuprofen
  • Fat soluble vitamins
  • Fenofibrate
  • Fenofibric Acid
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Fluvastatin
  • Folic Acid, Vitamin B9
  • Furosemide
  • Gemfibrozil
  • Glipizide
  • Glipizide; Metformin
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrocodone; Ibuprofen
  • Hydrocortisone
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Imipramine
  • Iron
  • Iron Salts
  • Isotretinoin
  • Lansoprazole; Naproxen
  • Leflunomide
  • Levomefolate
  • Lomitapide
  • Loperamide
  • Loperamide; Simethicone
  • Lovastatin; Niacin
  • Meloxicam
  • Methotrexate
  • Methylprednisolone
  • Metronidazole
  • Mycophenolate
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Obeticholic Acid
  • Paricalcitol
  • Penicillin G
  • Penicillin G Benzathine
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Phytonadione, Vitamin K1
  • Piroxicam
  • Polysaccharide-Iron Complex
  • Pravastatin
  • Prednisone
  • Propranolol
  • Raloxifene
  • Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
  • Spironolactone
  • Sulfinpyrazone
  • Teriflunomide
  • Tetracyclines
  • Thiazide diuretics
  • Thyroid hormones
  • Tinidazole
  • Torsemide
  • Tretinoin, ATRA
  • Ursodeoxycholic Acid, Ursodiol
  • Valproic Acid, Divalproex Sodium
  • Vancomycin
  • Vitamin A
  • Vitamin E
  • Warfarin

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