Chlorthalidone Clonidine

Chlorthalidone Clonidine Brand Name– Clorpres | Combipres

What is Chlorthalidone Clonidine

Chlorthalidone clonidine is a combination product for the treatment of hypertension.

Chlorthalidone is a thiazide-like diuretic. Clonidine is a centrally acting alpha2 agonist.

These drugs have additive hypotensive activity; the combination produces a more pronounced antihypertensive response than that of either drug alone in equivalent doses. This fixed combination drug is not indicated for initial therapy of hypertension.

Therapy for patients with hypertension should be titrated to the individual patient. If the fixed combination of chlorthalidone; clonidine represents the dosage required by the patient, its use may be more convenient than that of each drug given individually.

Chlorthalidone clonidine was approved by the FDA in February 1997.

Indications

  • hypertension

For the treatment of hypertension

NOTE: Clonidine; chlorthalidone fixed combination therapy is not indicated for initial antihypertensive therapy. The initial dose must be titrated to the individual patient. If the fixed combination represents the individual dosages required for the patient, its use may be more convenient in patient management.

Side Effects

  1. agranulocytosis
  2. alopecia
  3. angioedema
  4. anorexia
  5. anxiety
  6. aplastic anemia
  7. arthralgia
  8. AV block
  9. blurred vision
  10. bradycardia
  11. constipation
  12. delirium
  13. depression
  14. diabetes mellitus
  15. diarrhea
  16. dizziness
  17. drowsiness
  18. elevated hepatic enzymes
  19. fatigue
  20. fever
  21. glycosuria
  22. gout
  23. gynecomastia
  24. hallucinations
  25. headache
  26. heart failure
  27. hepatitis
  28. hyperglycemia
  29. hypertension
  30. hyperuricemia
  31. hypochloremia
  32. hypokalemia
  33. hyponatremia
  34. hypotension
  35. impotence (erectile dysfunction)
  36. increased urinary frequency
  37. insomnia
  38. jaundice
  39. leukopenia
  40. libido decrease
  41. malaise
  42. metabolic alkalosis
  43. muscle cramps
  44. myalgia
  45. nasal dryness
  46. nausea
  47. nocturia
  48. orthostatic hypotension
  49. pallor
  50. palpitations
  51. pancreatitis
  52. paresthesias
  53. parotitis
  54. peripheral vasoconstriction
  55. photosensitivity
  56. pruritus
  57. purpura
  58. rash
  59. restlessness
  60. sinus tachycardia
  61. thrombocytopenia
  62. toxic epidermal necrolysis
  63. urinary retention
  64. urticaria
  65. vasculitis
  66. vertigo
  67. vomiting
  68. weakness
  69. weight gain
  70. withdrawal
  71. xanthopsia
  72. xerostomia

Monitoring Parameters

  • blood glucose
  • blood pressure
  • serum calcium
  • serum creatinine/BUN
  • serum electrolytes
  • serum magnesium
  • serum uric acid

Contraindications

  • abrupt discontinuation
  • anuria
  • asthma
  • bradycardia
  • breast-feeding
  • cerebrovascular disease
  • children
  • diabetes mellitus
  • driving or operating machinery
  • geriatric
  • gout
  • hepatic disease
  • hyperglycemia
  • hyperuricemia
  • hypochloremia
  • hypokalemia
  • hyponatremia
  • hypovolemia
  • infants
  • metabolic alkalosis
  • myocardial infarction
  • neonates
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • sulfonamide hypersensitivity
  • surgery
  • systemic lupus erythematosus (SLE)
  • thiazide diuretic hypersensitivity
  • vomiting

Interactions

  • Acarbose
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acetohexamide
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alendronate; Cholecalciferol
  • Alfentanil
  • Allopurinol
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Alprostadil
  • Amifostine
  • Aminolevulinic Acid
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amoxapine
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  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Atracurium
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  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
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  • Chloroprocaine
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  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
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  • Diethylpropion
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  • Enalapril, Enalaprilat
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  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Ephedrine
  • Epinephrine
  • Epoprostenol
  • Ergocalciferol, Vitamin D2
  • Ertugliflozin
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  • Esomeprazole; Naproxen
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  • Ethanol
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  • Etomidate
  • Exenatide
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Flavoxate
  • Fluocinolone; Hydroquinone; Tretinoin
  • Fluoxetine
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  • Fluphenazine
  • Flurazepam
  • Flurbiprofen
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  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
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  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Granisetron
  • Guaifenesin; Hydrocodone
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  • Haloperidol
  • Halothane
  • Homatropine; Hydrocodone
  • Hydralazine; Isosorbide Dinitrate, ISDN
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  • Hydrochlorothiazide, HCTZ; Moexipril
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  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen
  • Ibuprofen lysine
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  • Ziconotide
  • Ziprasidone
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