Chlorthalidone Clonidine

Chlorthalidone Clonidine Brand Name– Clorpres | Combipres

What is Chlorthalidone Clonidine

Chlorthalidone clonidine is a combination product for the treatment of hypertension.

Chlorthalidone is a thiazide-like diuretic. Clonidine is a centrally acting alpha₂ agonist.

These drugs have additive hypotensive activity; the combination produces a more pronounced antihypertensive response than that of either drug alone in equivalent doses. This fixed combination drug is not indicated for initial therapy of hypertension.

Therapy for patients with hypertension should be titrated to the individual patient. If the fixed combination of chlorthalidone; clonidine represents the dosage required by the patient, its use may be more convenient than that of each drug given individually.

Chlorthalidone clonidine was approved by the FDA in February 1997.

Indications

• hypertension

For the treatment of hypertension

NOTE: Clonidine; chlorthalidone fixed combination therapy is not indicated for initial antihypertensive therapy. The initial dose must be titrated to the individual patient. If the fixed combination represents the individual dosages required for the patient, its use may be more convenient in patient management.

Side Effects

1. agranulocytosis
2. alopecia
3. angioedema
4. anorexia
5. anxiety
6. aplastic anemia
7. arthralgia
8. AV block
9. blurred vision
10. bradycardia
11. constipation
12. delirium
13. depression
14. diabetes mellitus
15. diarrhea
16. dizziness
17. drowsiness
18. elevated hepatic enzymes
19. fatigue
20. fever
21. glycosuria
22. gout
23. gynecomastia
24. hallucinations
25. headache
26. heart failure
27. hepatitis
28. hyperglycemia
29. hypertension
30. hyperuricemia
31. hypochloremia
32. hypokalemia
33. hyponatremia
34. hypotension
35. impotence (erectile dysfunction)
36. increased urinary frequency
37. insomnia
38. jaundice
39. leukopenia
40. libido decrease
41. malaise
42. metabolic alkalosis
43. muscle cramps
44. myalgia
45. nasal dryness
46. nausea
47. nocturia
48. orthostatic hypotension
49. pallor
50. palpitations
51. pancreatitis
52. paresthesias
53. parotitis
54. peripheral vasoconstriction
55. photosensitivity
56. pruritus
57. purpura
58. rash
59. restlessness
60. sinus tachycardia
61. thrombocytopenia
62. toxic epidermal necrolysis
63. urinary retention
64. urticaria
65. vasculitis
66. vertigo
67. vomiting
68. weakness
69. weight gain
70. withdrawal
71. xanthopsia
72. xerostomia

Monitoring Parameters

• blood glucose
• blood pressure
• serum calcium
• serum creatinine/BUN
• serum electrolytes
• serum magnesium
• serum uric acid

Contraindications

• abrupt discontinuation
• anuria
• asthma
• bradycardia
• breast-feeding
• cerebrovascular disease
• children
• diabetes mellitus
• driving or operating machinery
• geriatric
• gout
• hepatic disease
• hyperglycemia
• hyperuricemia
• hypochloremia
• hypokalemia
• hyponatremia
• hypovolemia
• infants
• metabolic alkalosis
• myocardial infarction
• neonates
• pregnancy
• renal disease
• renal failure
• renal impairment
• sulfonamide hypersensitivity
• surgery
• systemic lupus erythematosus (SLE)
• thiazide diuretic hypersensitivity
• vomiting

Interactions

• Acarbose
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
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• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
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