Chlorpromazine

Chlorpromazine Brand Name– Thorazine

What is Chlorpromazine

Chlorpromazine is an aliphatic phenothiazine used mainly as an antipsychotic, although it is also useful as an antinauseant and for treating singultation (hiccups).

Chlorpromazine occasionally is used for relief of presurgical anxiety; for acute intermittent porphyria; and as an adjunct in the treatment of tetanus. It is used to treat severe behavioral problems in children.

Chlorpromazine is the prototype antipsychotic; the potency of other phenothiazine antipsychotics are compared to oral chlorpromazine 100 mg.

Chlorpromazine was first used to treat mental illness in Paris in 1951.

It was approved by the FDA in 1954 and was available in multiple dosage forms.

Thorazine® products were discontinued from manufacture by GlaxoSmithKline around 2002.

Generic products remain available in tablet and injection dosage forms.

Indications

1. acute intermittent porphyria
2. acute psychosis
3. agitation
4. attention-deficit hyperactivity disorder (ADHD)
5. behavioral or psychological symptoms of dementia
6. delirium
7. migraine
8. nausea/vomiting
9. neonatal abstinence syndrome
10. oppositional defiant disorder
11. schizophrenia
12. singultus (hiccups)
13. tetanus

Side Effects

1. agranulocytosis
2. akathisia
3. anaphylactoid reactions
4. angioedema
5. aplastic anemia
6. appetite stimulation
7. asphyxia
8. blurred vision
9. bronchospasm
10. cerebral edema
11. cholestasis
12. constipation
13. contact dermatitis
14. corneal opacification
15. dizziness
16. drowsiness
17. dysphagia
18. dystonic reaction
19. ejaculation dysfunction
20. elevated hepatic enzymes
21. eosinophilia
22. exfoliative dermatitis
23. fever
24. galactorrhea
25. glycosuria
26. gynecomastia
27. headache
28. hemolytic anemia
29. hepatitis
30. hyperglycemia
31. hyperprolactinemia
32. hyperthermia
33. hypoglycemia
34. hyponatremia
35. hypotension
36. hypothermia
37. ileus
38. impotence (erectile dysfunction)
39. infertility
40. jaundice
41. laryngeal edema
42. leukopenia
43. libido decrease
44. lupus-like symptoms
45. mastalgia
46. menstrual irregularity
47. miosis
48. mydriasis
49. nasal congestion
50. nausea
51. neuroleptic malignant syndrome
52. neutropenia
53. orthostatic hypotension
54. pancytopenia
55. peripheral edema
56. photosensitivity
57. polydipsia
58. priapism
59. pseudoparkinsonism
60. psychosis
61. purpura
62. QT prolongation
63. restlessness
64. retinopathy
65. seizures
66. SIADH
67. sinus tachycardia
68. skin hyperpigmentation
69. stroke
70. tardive dyskinesia
71. thrombocytopenia
72. torsade de pointes
73. toxic epidermal necrolysis
74. urinary retention
75. urticaria
76. ventricular tachycardia
77. visual impairment
78. water intoxication
79. weight gain
80. xerostomia

Monitoring Parameters

• AIMS assessment
• CBC
• ophthalmologic exam
• serum prolactin

Contraindications

• abrupt discontinuation
• accidental exposure
• agranulocytosis
• ambient temperature increase
• angina
• anticholinergic medications
• apheresis
• asthma
• AV block
• benzyl alcohol hypersensitivity
• bone marrow suppression
• bradycardia
• breast cancer
• breast-feeding
• bundle-branch block
• cardiomyopathy
• celiac disease
• chemotherapy
• children
• closed-angle glaucoma
• CNS depression
• coadministration with other CNS depressants
• coma
• dehydration
• dementia
• dental work
• driving or operating machinery
• dysphagia
• encephalopathy
• ethanol ingestion
• females
• fever
• geriatric
• GI obstruction
• head trauma
• heart failure
• hematological disease
• hepatic disease
• human immunodeficiency virus (HIV) infection
• hyperparathyroidism
• hyperprolactinemia
• hyperthermia
• hypocalcemia
• hypokalemia
• hypomagnesemia
• hypotension
• hypothermia
• hypothyroidism
• hypovolemia
• ileus
• infants
• infection
• infertility
• intracranial mass
• jaundice
• labor
• leukopenia
• long QT syndrome
• myocardial infarction
• neonates
• neurological disease
• neutropenia
• obstetric delivery
• ocular disease
• orthostatic hypotension
• parenteral administration
• Parkinson’s disease
• phenothiazine hypersensitivity
• pheochromocytoma
• pregnancy
• pregnancy testing
• prostatic hypertrophy
• pulmonary disease
• QT prolongation
• radiographic contrast administration
• renal failure
• Reye’s syndrome
• rheumatoid arthritis
• seizure disorder
• seizures
• sickle cell disease
• sleep deprivation
• strenuous exercise
• stroke
• suicidal ideation
• sulfite hypersensitivity
• sunlight (UV) exposure
• surgery
• systemic lupus erythematosus (SLE)
• tachycardia
• tardive dyskinesia
• tobacco smoking
• torsade de pointes
• urinary retention
• vomiting

Interactions

• Abarelix
• Acarbose
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Acetohexamide
• Alfentanil
• Alfuzosin
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
• Alpha-glucosidase Inhibitors
• Alprazolam
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Amantadine
• Amifampridine
• Amikacin
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminoglycosides
• Aminolevulinic Acid
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Anagrelide
• Antacids
• Anticholinergics
• Anxiolytics; Sedatives; and Hypnotics
• Apomorphine
• Apraclonidine
• Aripiprazole
• Arsenic Trioxide
• Artemether; Lumefantrine
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atazanavir; Cobicistat
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Azithromycin
• Baclofen
• Barbiturates
• Bedaquiline
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benztropine
• Bepridil
• Bethanechol
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Brexpiprazole
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Cabergoline
• Calcium Carbonate; Magnesium Hydroxide
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capsaicin; Metaxalone
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cariprazine
• Carisoprodol
• Carteolol
• Carvedilol
• Cenobamate
• Central-acting adrenergic agents
• Ceritinib
• Cetrorelix
• Cevimeline
• Charcoal
• Chlophedianol; Dexbrompheniramine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlophedianol; Guaifenesin; Phenylephrine
• Chloral Hydrate
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroquine
• Chlorothiazide
• Chlorpheniramine
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Phenylephrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpropamide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Cimetidine
• Ciprofloxacin
• Cisapride
• Citalopram
• Clarithromycin
• Clemastine
• Clindamycin; Tretinoin
• Clobazam
• Clofazimine
• Clomipramine
• Clonazepam
• Clorazepate
• Clozapine
• Cobicistat
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Crizotinib
• Cyclobenzaprine
• Dantrolene
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasatinib
• Degarelix
• Desflurane
• Desipramine
• Desmopressin
• Desvenlafaxine
• Deutetrabenazine
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmedetomidine
• Dexmethylphenidate
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Dicyclomine
• Diethylpropion
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dimenhydrinate
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Disopyramide
• Dofetilide
• Dolasetron
• Dolutegravir; Rilpivirine
• Donepezil
• Donepezil; Memantine
• Dopamine
• Dorzolamide; Timolol
• Doxepin
• Doxorubicin
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Drospirenone; Ethinyl Estradiol
• Drospirenone; Ethinyl Estradiol; Levomefolate
• Duloxetine
• Dutasteride; Tamsulosin
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Eliglustat
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir alafenamide
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Enalapril; Hydrochlorothiazide, HCTZ
• Encainide
• Encorafenib
• Enflurane
• enteral feedings
• Entrectinib
• Ephedrine
• Epinephrine
• Eprosartan; Hydrochlorothiazide, HCTZ
• Eribulin
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Esketamine
• Estazolam
• Eszopiclone
• Ethanol
• Ethinyl Estradiol
• Ethinyl Estradiol; Desogestrel
• Ethinyl Estradiol; Ethynodiol Diacetate
• Ethinyl Estradiol; Etonogestrel
• Ethinyl Estradiol; Levonorgestrel
• Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
• Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
• Ethinyl Estradiol; Norelgestromin
• Ethinyl Estradiol; Norethindrone
• Ethinyl Estradiol; Norethindrone Acetate
• Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
• Ethinyl Estradiol; Norethindrone; Ferrous fumarate
• Ethinyl Estradiol; Norgestimate
• Ethinyl Estradiol; Norgestrel
• Ethosuximide
• Ethotoin
• Etomidate
• Ezogabine
• Felbamate
• Fentanyl
• Fingolimod
• Flavoxate
• Flecainide
• Flibanserin
• Fluconazole
• Flucytosine
• Fluocinolone; Hydroquinone; Tretinoin
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Fluvoxamine
• food
• Foscarnet
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Fospropofol
• Gabapentin
• Galantamine
• Ganirelix
• Gemifloxacin
• Gemtuzumab Ozogamicin
• Gentamicin
• Gilteritinib
• Glasdegib
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Glycopyrrolate
• Glycopyrrolate; Formoterol
• Goserelin
• Granisetron
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Phenylephrine
• Guanidine
• Halobetasol; Tazarotene
• Halofantrine
• Halogenated Anesthetics
• Haloperidol
• Halothane
• Histrelin
• Homatropine; Hydrocodone
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxychloroquine
• Hydroxyzine
• Hyoscyamine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Ibutilide
• Iloperidone
• Imipramine
• Incretin Mimetics
• Indacaterol; Glycopyrrolate
• Indapamide
• Inotuzumab Ozogamicin
• Insulins
• Iohexol
• Iopamidol
• Iopromide
• Ioversol
• Ipecac
• Isocarboxazid
• Isoflurane
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Isosulfan Blue
• Itraconazole
• Ivosidenib
• Kanamycin
• Ketamine
• Ketoconazole
• Lamotrigine
• Lanthanum Carbonate
• Lapatinib
• Lasmiditan
• Lefamulin
• Lemborexant
• Lenvatinib
• Leuprolide
• Leuprolide; Norethindrone
• Levetiracetam
• Levodopa
• Levofloxacin
• Levomethadyl
• Levorphanol
• Linagliptin
• Linagliptin; Metformin
• Lithium
• Lofexidine
• Lomefloxacin
• Long-acting beta-agonists
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Lorazepam
• Loxapine
• Lumateperone
• Lurasidone
• Macimorelin
• Magnesium Hydroxide
• Magnesium Salts
• Maprotiline
• Meclizine
• Mefloquine
• Meglitinides
• Melatonin
• Mepenzolate
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Mequinol; Tretinoin
• Mestranol; Norethindrone
• Metaxalone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methocarbamol
• Methohexital
• Methoxsalen
• Methscopolamine
• Methsuximide
• Methyclothiazide
• Methylphenidate
• Metoclopramide
• Metolazone
• Metoprolol
• Metronidazole
• Metyrapone
• Metyrosine
• Mexiletine
• Midazolam
• Midostaurin
• Miglitol
• Minocycline
• Mirabegron
• Mirtazapine
• Mitotane
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Moxifloxacin
• Nabilone
• Nadolol
• Nafarelin
• Nalbuphine
• Naltrexone
• Nebivolol
• Nebivolol; Valsartan
• Nilotinib
• Nitroglycerin
• Non-Ionic Contrast Media
• Norepinephrine
• Norfloxacin
• Nortriptyline
• Octreotide
• Ofloxacin
• Olanzapine
• Omeprazole; Amoxicillin; Rifabutin
• Ondansetron
• Oritavancin
• Orphenadrine
• Osilodrostat
• Osimertinib
• Oxaliplatin
• Oxazepam
• Oxybutynin
• Oxycodone
• Oxymorphone
• Ozanimod
• Paliperidone
• Panobinostat
• Paromomycin
• Paroxetine
• Pasireotide
• Pazopanib
• Peginterferon Alfa-2b
• Pemoline
• Pentamidine
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Pergolide
• Perphenazine
• Perphenazine; Amitriptyline
• Pexidartinib
• Phenelzine
• Phenobarbital
• Phentermine; Topiramate
• Phenylephrine
• Phenylephrine; Promethazine
• Phenytoin
• Photosensitizing agents (topical)
• Pilocarpine
• Pimavanserin
• Pimozide
• Pindolol
• Pioglitazone
• Pitolisant
• Plazomicin
• Porfimer
• Posaconazole
• Pramipexole
• Pramlintide
• Pregabalin
• Prilocaine; Epinephrine
• Primaquine
• Primidone
• Procainamide
• Procarbazine
• Prochlorperazine
• Promethazine
• Propafenone
• Propantheline
• Propoxyphene
• Propranolol
• Protriptyline
• Pyrimethamine
• Pyrimethamine; Sulfadoxine
• Quazepam
• Quetiapine
• Quinidine
• Quinine
• Ranolazine
• Rasagiline
• Remifentanil
• Ribociclib
• Ribociclib; Letrozole
• Rifabutin
• Rifampin
• Rifamycins
• Rifapentine
• Rilpivirine
• Riluzole
• Risperidone
• Rivastigmine
• Rolapitant
• Romidepsin
• Ropinirole
• Rosiglitazone
• Rotigotine
• Safinamide
• Saquinavir
• Saxagliptin
• Scopolamine
• Secobarbital
• Segesterone Acetate; Ethinyl Estradiol
• Selegiline
• Selpercatinib
• Sertraline
• Sevoflurane
• SGLT2 Inhibitors
• Short-acting beta-agonists
• Simvastatin; Sitagliptin
• Siponimod
• Sitagliptin
• Sodium Oxybate
• Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
• Solifenacin
• Sorafenib
• Sotalol
• Sparfloxacin
• St. John’s Wort, Hypericum perforatum
• Streptomycin
• Sufentanil
• Sulfonylureas
• Sunitinib
• Tacrine
• Tacrolimus
• Tamoxifen
• Tamsulosin
• Tapentadol
• Tazarotene
• Telavancin
• Telithromycin
• Temazepam
• Tetrabenazine
• Thalidomide
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thioridazine
• Thiothixene
• Tiagabine
• Timolol
• tobacco
• Tobramycin
• Tolazamide
• Tolbutamide
• Tolterodine
• Topiramate
• Toremifene
• Tramadol
• Tranexamic Acid
• Tranylcypromine
• Trazodone
• Tretinoin, ATRA
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trihexyphenidyl
• Trimethobenzamide
• Trimipramine
• Triprolidine
• Triptorelin
• Trospium
• Valproic Acid, Divalproex Sodium
• Vandetanib
• Vardenafil
• Vemurafenib
• Venlafaxine
• Verteporfin
• Vigabatrin
• Voriconazole
• Vorinostat
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolpidem
• Zonisamide