Chlorpromazine

Chlorpromazine Brand Name– Thorazine

What is Chlorpromazine

Chlorpromazine is an aliphatic phenothiazine used mainly as an antipsychotic, although it is also useful as an antinauseant and for treating singultation (hiccups).

Chlorpromazine occasionally is used for relief of presurgical anxiety; for acute intermittent porphyria; and as an adjunct in the treatment of tetanus. It is used to treat severe behavioral problems in children.

Chlorpromazine is the prototype antipsychotic; the potency of other phenothiazine antipsychotics are compared to oral chlorpromazine 100 mg.

Chlorpromazine was first used to treat mental illness in Paris in 1951.

It was approved by the FDA in 1954 and was available in multiple dosage forms.

Thorazine® products were discontinued from manufacture by GlaxoSmithKline around 2002.

Generic products remain available in tablet and injection dosage forms.

Indications

  1. acute intermittent porphyria
  2. acute psychosis
  3. agitation
  4. attention-deficit hyperactivity disorder (ADHD)
  5. behavioral or psychological symptoms of dementia
  6. delirium
  7. migraine
  8. nausea/vomiting
  9. neonatal abstinence syndrome
  10. oppositional defiant disorder
  11. schizophrenia
  12. singultus (hiccups)
  13. tetanus

Side Effects

  1. agranulocytosis
  2. akathisia
  3. anaphylactoid reactions
  4. angioedema
  5. aplastic anemia
  6. appetite stimulation
  7. asphyxia
  8. blurred vision
  9. bronchospasm
  10. cerebral edema
  11. cholestasis
  12. constipation
  13. contact dermatitis
  14. corneal opacification
  15. dizziness
  16. drowsiness
  17. dysphagia
  18. dystonic reaction
  19. ejaculation dysfunction
  20. elevated hepatic enzymes
  21. eosinophilia
  22. exfoliative dermatitis
  23. fever
  24. galactorrhea
  25. glycosuria
  26. gynecomastia
  27. headache
  28. hemolytic anemia
  29. hepatitis
  30. hyperglycemia
  31. hyperprolactinemia
  32. hyperthermia
  33. hypoglycemia
  34. hyponatremia
  35. hypotension
  36. hypothermia
  37. ileus
  38. impotence (erectile dysfunction)
  39. infertility
  40. jaundice
  41. laryngeal edema
  42. leukopenia
  43. libido decrease
  44. lupus-like symptoms
  45. mastalgia
  46. menstrual irregularity
  47. miosis
  48. mydriasis
  49. nasal congestion
  50. nausea
  51. neuroleptic malignant syndrome
  52. neutropenia
  53. orthostatic hypotension
  54. pancytopenia
  55. peripheral edema
  56. photosensitivity
  57. polydipsia
  58. priapism
  59. pseudoparkinsonism
  60. psychosis
  61. purpura
  62. QT prolongation
  63. restlessness
  64. retinopathy
  65. seizures
  66. SIADH
  67. sinus tachycardia
  68. skin hyperpigmentation
  69. stroke
  70. tardive dyskinesia
  71. thrombocytopenia
  72. torsade de pointes
  73. toxic epidermal necrolysis
  74. urinary retention
  75. urticaria
  76. ventricular tachycardia
  77. visual impairment
  78. water intoxication
  79. weight gain
  80. xerostomia

Monitoring Parameters

  • AIMS assessment
  • CBC
  • ophthalmologic exam
  • serum prolactin

Contraindications

  • abrupt discontinuation
  • accidental exposure
  • agranulocytosis
  • ambient temperature increase
  • angina
  • anticholinergic medications
  • apheresis
  • asthma
  • AV block
  • benzyl alcohol hypersensitivity
  • bone marrow suppression
  • bradycardia
  • breast cancer
  • breast-feeding
  • bundle-branch block
  • cardiomyopathy
  • celiac disease
  • chemotherapy
  • children
  • closed-angle glaucoma
  • CNS depression
  • coadministration with other CNS depressants
  • coma
  • dehydration
  • dementia
  • dental work
  • driving or operating machinery
  • dysphagia
  • encephalopathy
  • ethanol ingestion
  • females
  • fever
  • geriatric
  • GI obstruction
  • head trauma
  • heart failure
  • hematological disease
  • hepatic disease
  • human immunodeficiency virus (HIV) infection
  • hyperparathyroidism
  • hyperprolactinemia
  • hyperthermia
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • hypotension
  • hypothermia
  • hypothyroidism
  • hypovolemia
  • ileus
  • infants
  • infection
  • infertility
  • intracranial mass
  • jaundice
  • labor
  • leukopenia
  • long QT syndrome
  • myocardial infarction
  • neonates
  • neurological disease
  • neutropenia
  • obstetric delivery
  • ocular disease
  • orthostatic hypotension
  • parenteral administration
  • Parkinson’s disease
  • phenothiazine hypersensitivity
  • pheochromocytoma
  • pregnancy
  • pregnancy testing
  • prostatic hypertrophy
  • pulmonary disease
  • QT prolongation
  • radiographic contrast administration
  • renal failure
  • Reye’s syndrome
  • rheumatoid arthritis
  • seizure disorder
  • seizures
  • sickle cell disease
  • sleep deprivation
  • strenuous exercise
  • stroke
  • suicidal ideation
  • sulfite hypersensitivity
  • sunlight (UV) exposure
  • surgery
  • systemic lupus erythematosus (SLE)
  • tachycardia
  • tardive dyskinesia
  • tobacco smoking
  • torsade de pointes
  • urinary retention
  • vomiting

Interactions

  • Abarelix
  • Acarbose
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Acetohexamide
  • Alfentanil
  • Alfuzosin
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alosetron
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Aluminum Hydroxide
  • Aluminum Hydroxide; Magnesium Carbonate
  • Aluminum Hydroxide; Magnesium Hydroxide
  • Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
  • Aluminum Hydroxide; Magnesium Trisilicate
  • Amantadine
  • Amifampridine
  • Amikacin
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminoglycosides
  • Aminolevulinic Acid
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amobarbital
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Anagrelide
  • Antacids
  • Anticholinergics
  • Anxiolytics; Sedatives; and Hypnotics
  • Apomorphine
  • Apraclonidine
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Articaine; Epinephrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir; Cobicistat
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Azilsartan; Chlorthalidone
  • Azithromycin
  • Baclofen
  • Barbiturates
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Bepridil
  • Bethanechol
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Brexpiprazole
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cabergoline
  • Calcium Carbonate; Magnesium Hydroxide
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carisoprodol
  • Carteolol
  • Carvedilol
  • Cenobamate
  • Central-acting adrenergic agents
  • Ceritinib
  • Cetrorelix
  • Cevimeline
  • Charcoal
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chloroquine
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Cimetidine
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clemastine
  • Clindamycin; Tretinoin
  • Clobazam
  • Clofazimine
  • Clomipramine
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Crizotinib
  • Cyclobenzaprine
  • Dantrolene
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasatinib
  • Degarelix
  • Desflurane
  • Desipramine
  • Desmopressin
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dexmethylphenidate
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dicyclomine
  • Diethylpropion
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dimenhydrinate
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Dopamine
  • Dorzolamide; Timolol
  • Doxepin
  • Doxorubicin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Encainide
  • Encorafenib
  • Enflurane
  • enteral feedings
  • Entrectinib
  • Ephedrine
  • Epinephrine
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Eribulin
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Esketamine
  • Estazolam
  • Eszopiclone
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethosuximide
  • Ethotoin
  • Etomidate
  • Ezogabine
  • Felbamate
  • Fentanyl
  • Fingolimod
  • Flavoxate
  • Flecainide
  • Flibanserin
  • Fluconazole
  • Flucytosine
  • Fluocinolone; Hydroquinone; Tretinoin
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fluvoxamine
  • food
  • Foscarnet
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fosphenytoin
  • Fospropofol
  • Gabapentin
  • Galantamine
  • Ganirelix
  • Gemifloxacin
  • Gemtuzumab Ozogamicin
  • Gentamicin
  • Gilteritinib
  • Glasdegib
  • Glimepiride
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide
  • Glipizide; Metformin
  • Glyburide
  • Glyburide; Metformin
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Goserelin
  • Granisetron
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guanidine
  • Halobetasol; Tazarotene
  • Halofantrine
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Histrelin
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxyzine
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Incretin Mimetics
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Inotuzumab Ozogamicin
  • Insulins
  • Iohexol
  • Iopamidol
  • Iopromide
  • Ioversol
  • Ipecac
  • Isocarboxazid
  • Isoflurane
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isosulfan Blue
  • Itraconazole
  • Ivosidenib
  • Kanamycin
  • Ketamine
  • Ketoconazole
  • Lamotrigine
  • Lanthanum Carbonate
  • Lapatinib
  • Lasmiditan
  • Lefamulin
  • Lemborexant
  • Lenvatinib
  • Leuprolide
  • Leuprolide; Norethindrone
  • Levetiracetam
  • Levodopa
  • Levofloxacin
  • Levomethadyl
  • Levorphanol
  • Linagliptin
  • Linagliptin; Metformin
  • Lithium
  • Lofexidine
  • Lomefloxacin
  • Long-acting beta-agonists
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorazepam
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Macimorelin
  • Magnesium Hydroxide
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Mefloquine
  • Meglitinides
  • Melatonin
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Mequinol; Tretinoin
  • Mestranol; Norethindrone
  • Metaxalone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methocarbamol
  • Methohexital
  • Methoxsalen
  • Methscopolamine
  • Methsuximide
  • Methyclothiazide
  • Methylphenidate
  • Metoclopramide
  • Metolazone
  • Metoprolol
  • Metronidazole
  • Metyrapone
  • Metyrosine
  • Mexiletine
  • Midazolam
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  • Miglitol
  • Minocycline
  • Mirabegron
  • Mirtazapine
  • Mitotane
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Moxifloxacin
  • Nabilone
  • Nadolol
  • Nafarelin
  • Nalbuphine
  • Naltrexone
  • Nebivolol
  • Nebivolol; Valsartan
  • Nilotinib
  • Nitroglycerin
  • Non-Ionic Contrast Media
  • Norepinephrine
  • Norfloxacin
  • Nortriptyline
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Omeprazole; Amoxicillin; Rifabutin
  • Ondansetron
  • Oritavancin
  • Orphenadrine
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Oxazepam
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Ozanimod
  • Paliperidone
  • Panobinostat
  • Paromomycin
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Peginterferon Alfa-2b
  • Pemoline
  • Pentamidine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Pergolide
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Pexidartinib
  • Phenelzine
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Photosensitizing agents (topical)
  • Pilocarpine
  • Pimavanserin
  • Pimozide
  • Pindolol
  • Pioglitazone
  • Pitolisant
  • Plazomicin
  • Porfimer
  • Posaconazole
  • Pramipexole
  • Pramlintide
  • Pregabalin
  • Prilocaine; Epinephrine
  • Primaquine
  • Primidone
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Propantheline
  • Propoxyphene
  • Propranolol
  • Protriptyline
  • Pyrimethamine
  • Pyrimethamine; Sulfadoxine
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Rasagiline
  • Remifentanil
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifabutin
  • Rifampin
  • Rifamycins
  • Rifapentine
  • Rilpivirine
  • Riluzole
  • Risperidone
  • Rivastigmine
  • Rolapitant
  • Romidepsin
  • Ropinirole
  • Rosiglitazone
  • Rotigotine
  • Safinamide
  • Saquinavir
  • Saxagliptin
  • Scopolamine
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Selpercatinib
  • Sertraline
  • Sevoflurane
  • SGLT2 Inhibitors
  • Short-acting beta-agonists
  • Simvastatin; Sitagliptin
  • Siponimod
  • Sitagliptin
  • Sodium Oxybate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sparfloxacin
  • St. John’s Wort, Hypericum perforatum
  • Streptomycin
  • Sufentanil
  • Sulfonylureas
  • Sunitinib
  • Tacrine
  • Tacrolimus
  • Tamoxifen
  • Tamsulosin
  • Tapentadol
  • Tazarotene
  • Telavancin
  • Telithromycin
  • Temazepam
  • Tetrabenazine
  • Thalidomide
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Tiagabine
  • Timolol
  • tobacco
  • Tobramycin
  • Tolazamide
  • Tolbutamide
  • Tolterodine
  • Topiramate
  • Toremifene
  • Tramadol
  • Tranexamic Acid
  • Tranylcypromine
  • Trazodone
  • Tretinoin, ATRA
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Trimipramine
  • Triprolidine
  • Triptorelin
  • Trospium
  • Valproic Acid, Divalproex Sodium
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Verteporfin
  • Vigabatrin
  • Voriconazole
  • Vorinostat
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolpidem
  • Zonisamide
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