Chlorpheniramine Phenylephrine

Chlorpheniramine Phenylephrine Brand Names

AccuHist | Actifed Cold and Allergy | AllanTan | Allerest PE | AlleRx | BP Allergy Junior | Cardec | Ceron | Chlor-Mes JR | ChlorTan D | CP-Dec | C-Phen | Dallergy | Dallergy-JR | Dec-Chlorphen | ED A-HIST | Ed ChlorPed D | ED-A-Hist | ED-ChlorPed D | Histadec | Histex SR | LoHist | Maxichlor PEH | Myci Chlorped D | Nasohist | NoHist | NoHist LQ | Nuhist | Ny-Tannic | PD-Hist D | PE Tann/CP Tann | PediaTan D | Phenabid | Phenagil | Phenclor | Phenylhistine | P-Tann D | Relera | Rescon JR | Rhinatate-NF | Ricobid | Rondec | Rondex | R-Tanna | Rynatan | Rynatan Pediatric | Ry-Tann | Sildec PE | Sonahist | Sudafed PE Sinus and Allergy | TanaHist-D | Tannate | Triaminic Cold and Allergy | Trigofen | Virdec

What is Chlorpheniramine Phenylephrine

Chlorpheniramine and phenylephrine are used together for relief of upper respiratory symptoms such as nasal congestion, rhinorrhea, and sneezing associated with allergic or vasomotor rhinitis, the common cold, or sinusitis.

Chlorpheniramine is a first generation sedating antihistamine (H1-blocker) of the alkylamine class commonly used for treating symptoms related to histamine release such as rhinorrhea and sneezing.

Phenylephrine is a sympathomimetic agent used as a decongestant to decrease nasal and sinus congestion.

Chlorpheniramine phenylephrine is available orally in a variety of preparations for adults and children.

Indications

  1. allergic rhinitis
  2. common cold
  3. nasal congestion
  4. rhinorrhea
  5. sneezing

For temporary relief of symptoms due to the common cold, allergic rhinitis, or other upper respiratory allergies (e.g., rhinorrhea, nasal congestion, sneezing, itchy, watery eyes, itching of the nose or throat)

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. angina
  4. anorexia
  5. anxiety
  6. arrhythmia exacerbation
  7. ataxia
  8. blurred vision
  9. bronchial secretions
  10. constipation
  11. diarrhea
  12. diplopia
  13. dizziness
  14. drowsiness
  15. dyspepsia
  16. dysuria
  17. excitability
  18. hallucinations
  19. headache
  20. hypertension
  21. hypertensive crisis
  22. hypotension
  23. insomnia
  24. irritability
  25. leukopenia
  26. mydriasis
  27. myocardial infarction
  28. nausea
  29. pallor
  30. palpitations
  31. photophobia
  32. polyuria
  33. premature ventricular contractions (PVCs)
  34. pruritus
  35. psychosis
  36. rash
  37. restlessness
  38. seizures
  39. sinus tachycardia
  40. stroke
  41. supraventricular tachycardia (SVT)
  42. thrombocytopenia
  43. tremor
  44. urinary retention
  45. urticaria
  46. visual impairment
  47. vomiting
  48. weakness
  49. wheezing
  50. xerophthalmia
  51. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute myocardial infarction
  • aneurysm
  • angina
  • anticholinergic medications
  • arteriosclerosis
  • asthma
  • atrial fibrillation
  • atrial flutter
  • AV block
  • bladder obstruction
  • bradycardia
  • breast-feeding
  • bronchitis
  • bundle-branch block
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • cerebrovascular disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • constipation
  • contact lenses
  • coronary artery disease
  • diabetes mellitus
  • driving or operating machinery
  • emphysema
  • geriatric
  • GI disease
  • GI obstruction
  • heart failure
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • ileus
  • increased intraocular pressure
  • infants
  • intracranial bleeding
  • labor
  • MAOI therapy
  • myocardial infarction
  • neonates
  • obstetric delivery
  • organic brain syndrome
  • peptic ulcer disease
  • peripheral vascular disease
  • pregnancy
  • prostatic hypertrophy
  • pulmonary disease
  • pyloric stenosis
  • renal disease
  • renal failure
  • renal impairment
  • status asthmaticus
  • stroke
  • tachycardia
  • thyrotoxicosis
  • ulcerative colitis
  • urinary retention
  • ventricular fibrillation
  • ventricular tachycardia

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
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  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Metformin
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  • Alosetron
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  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
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  • Carbetapentane; Guaifenesin; Phenylephrine
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  • Carbetapentane; Phenylephrine; Pyrilamine
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  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
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  • Cardiac glycosides
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  • Cenobamate
  • Cetirizine
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  • Chlorothiazide
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Ciclesonide
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  • Clozapine
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  • Cocaine
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  • Codeine; Guaifenesin
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  • Codeine; Promethazine
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  • Dapagliflozin; Metformin
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  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deflazacort
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Desmopressin
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  • Dexamethasone
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
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  • Dextromethorphan; Promethazine
  • Diazepam
  • Diethylpropion
  • Digitoxin
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Donepezil
  • Donepezil; Memantine
  • Dorzolamide; Timolol
  • Doxazosin
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Dulaglutide
  • Dutasteride; Tamsulosin
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Entacapone
  • Epinephrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esketamine
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  • Ethacrynic Acid
  • Ethanol
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  • Fentanyl
  • Fexofenadine; Pseudoephedrine
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  • Formoterol; Mometasone
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fospropofol
  • Furosemide
  • Gabapentin
  • Galantamine
  • Gentamicin
  • Ginger, Zingiber officinale
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  • Glipizide; Metformin
  • Glyburide; Metformin
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  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
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  • Guanabenz
  • Halogenated Anesthetics
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  • Heparin
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  • Hyaluronidase
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  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydrocortisone
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Iloperidone
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