Chlorpheniramine Phenylephrine

Chlorpheniramine Phenylephrine Brand Names

AccuHist | Actifed Cold and Allergy | AllanTan | Allerest PE | AlleRx | BP Allergy Junior | Cardec | Ceron | Chlor-Mes JR | ChlorTan D | CP-Dec | C-Phen | Dallergy | Dallergy-JR | Dec-Chlorphen | ED A-HIST | Ed ChlorPed D | ED-A-Hist | ED-ChlorPed D | Histadec | Histex SR | LoHist | Maxichlor PEH | Myci Chlorped D | Nasohist | NoHist | NoHist LQ | Nuhist | Ny-Tannic | PD-Hist D | PE Tann/CP Tann | PediaTan D | Phenabid | Phenagil | Phenclor | Phenylhistine | P-Tann D | Relera | Rescon JR | Rhinatate-NF | Ricobid | Rondec | Rondex | R-Tanna | Rynatan | Rynatan Pediatric | Ry-Tann | Sildec PE | Sonahist | Sudafed PE Sinus and Allergy | TanaHist-D | Tannate | Triaminic Cold and Allergy | Trigofen | Virdec

What is Chlorpheniramine Phenylephrine

Chlorpheniramine and phenylephrine are used together for relief of upper respiratory symptoms such as nasal congestion, rhinorrhea, and sneezing associated with allergic or vasomotor rhinitis, the common cold, or sinusitis.

Chlorpheniramine is a first generation sedating antihistamine (H1-blocker) of the alkylamine class commonly used for treating symptoms related to histamine release such as rhinorrhea and sneezing.

Phenylephrine is a sympathomimetic agent used as a decongestant to decrease nasal and sinus congestion.

Chlorpheniramine phenylephrine is available orally in a variety of preparations for adults and children.

Indications

1. allergic rhinitis
2. common cold
3. nasal congestion
4. rhinorrhea
5. sneezing

For temporary relief of symptoms due to the common cold, allergic rhinitis, or other upper respiratory allergies (e.g., rhinorrhea, nasal congestion, sneezing, itchy, watery eyes, itching of the nose or throat)

Side Effects

1. abdominal pain
2. agranulocytosis
3. angina
4. anorexia
5. anxiety
6. arrhythmia exacerbation
7. ataxia
8. blurred vision
9. bronchial secretions
10. constipation
11. diarrhea
12. diplopia
13. dizziness
14. drowsiness
15. dyspepsia
16. dysuria
17. excitability
18. hallucinations
19. headache
20. hypertension
21. hypertensive crisis
22. hypotension
23. insomnia
24. irritability
25. leukopenia
26. mydriasis
27. myocardial infarction
28. nausea
29. pallor
30. palpitations
31. photophobia
32. polyuria
33. premature ventricular contractions (PVCs)
34. pruritus
35. psychosis
36. rash
37. restlessness
38. seizures
39. sinus tachycardia
40. stroke
41. supraventricular tachycardia (SVT)
42. thrombocytopenia
43. tremor
44. urinary retention
45. urticaria
46. visual impairment
47. vomiting
48. weakness
49. wheezing
50. xerophthalmia
51. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• acute myocardial infarction
• aneurysm
• angina
• anticholinergic medications
• arteriosclerosis
• asthma
• atrial fibrillation
• atrial flutter
• AV block
• bladder obstruction
• bradycardia
• breast-feeding
• bronchitis
• bundle-branch block
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• constipation
• contact lenses
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• emphysema
• geriatric
• GI disease
• GI obstruction
• heart failure
• hepatic disease
• hypertension
• hyperthyroidism
• ileus
• increased intraocular pressure
• infants
• intracranial bleeding
• labor
• MAOI therapy
• myocardial infarction
• neonates
• obstetric delivery
• organic brain syndrome
• peptic ulcer disease
• peripheral vascular disease
• pregnancy
• prostatic hypertrophy
• pulmonary disease
• pyloric stenosis
• renal disease
• renal failure
• renal impairment
• status asthmaticus
• stroke
• tachycardia
• thyrotoxicosis
• ulcerative colitis
• urinary retention
• ventricular fibrillation
• ventricular tachycardia

Interactions

• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Alfentanil
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alosetron
• Alpha-blockers
• Alpha-glucosidase Inhibitors
• Alprazolam
• Amantadine
• Ambenonium Chloride
• Ambrisentan
• Amikacin
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminoglycosides
• Amiodarone
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxapine
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Anticholinergics
• Apomorphine
• Arformoterol
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• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atazanavir; Cobicistat
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Edrophonium
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Avanafil
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Baclofen
• Barbiturates
• Beclomethasone
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Benzphetamine
• Beta-blockers
• Betamethasone
• Betaxolol
• Bethanechol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bosentan
• Bretylium
• Brimonidine; Timolol
• Bromocriptine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Budesonide
• Budesonide; Formoterol
• Bumetanide
• Buprenorphine
• Buprenorphine; Naloxone
• Buspirone
• Butabarbital
• Butorphanol
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• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capsaicin; Metaxalone
• Captopril; Hydrochlorothiazide, HCTZ
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Pseudoephedrine
• Cardiac glycosides
• Carisoprodol
• Carteolol
• Carvedilol
• Celecoxib
• Cenobamate
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chlorothiazide
• Chlorpheniramine; Codeine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Pseudoephedrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Ciclesonide
• Clevidipine
• Clobazam
• Clonazepam
• Clonidine
• Clorazepate
• Clozapine
• Cobicistat
• Cocaine
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• Colchicine
• Colchicine; Probenecid
• COMT inhibitors
• Corticosteroids
• Cortisone
• Cyclobenzaprine
• Dantrolene
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Daratumumab; Hyaluronidase
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Deflazacort
• Desloratadine
• Desloratadine; Pseudoephedrine
• Desmopressin
• Deutetrabenazine
• Dexamethasone
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmedetomidine
• Dexmethylphenidate
• Dextroamphetamine
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Diazepam
• Diethylpropion
• Digitoxin
• Digoxin
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Dihydroergotamine
• Diltiazem
• Dipeptidyl Peptidase-4 Inhibitors
• Diphenhydramine; Hydrocodone; Phenylephrine
• Disopyramide
• Donepezil
• Donepezil; Memantine
• Dorzolamide; Timolol
• Doxazosin
• Doxorubicin
• Dronabinol
• Dronedarone
• Droperidol
• Dulaglutide
• Dutasteride; Tamsulosin
• Dyphylline
• Dyphylline; Guaifenesin
• Eliglustat
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Entacapone
• Epinephrine
• Epoprostenol
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergoloid Mesylates
• Ergonovine
• Ergot alkaloids
• Ergotamine
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Esketamine
• Esmolol
• Estazolam
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Etomidate
• Exenatide
• Ezogabine
• Felodipine
• Fentanyl
• Fexofenadine; Pseudoephedrine
• Flibanserin
• Fludrocortisone
• Flunisolide
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Fluticasone
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Formoterol
• Formoterol; Mometasone
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fospropofol
• Furosemide
• Gabapentin
• Galantamine
• Gentamicin
• Ginger, Zingiber officinale
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate; Formoterol
• Green Tea
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guaifenesin; Pseudoephedrine
• Guanabenz
• Halogenated Anesthetics
• Haloperidol
• Halothane
• Heparin
• Homatropine; Hydrocodone
• Hyaluronidase
• Hyaluronidase, Recombinant; Immune Globulin
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydrocortisone
• Hydromorphone
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Iloperidone
• Iloprost
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Iobenguane I 131
• Ionic Contrast Media
• Isocarboxazid
• Isoflurane
• Isradipine
• Kanamycin
• Ketamine
• Labetalol
• Lasmiditan
• Lemborexant
• Levalbuterol
• Levobetaxolol
• Levobunolol
• Levocetirizine
• Levomethadyl
• Levorphanol
• Levothyroxine
• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Linagliptin; Metformin
• Linezolid
• Liothyronine
• Liraglutide
• Lithium
• Lixisenatide
• Lofexidine
• Loop diuretics
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Loratadine
• Loratadine; Pseudoephedrine
• Lorazepam
• Loxapine
• Lumateperone
• Lurasidone
• Macitentan
• Magnesium Salts
• Maprotiline
• Mecamylamine
• Meclizine
• Meglitinides
• Melatonin
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Meprobamate
• Metaproterenol
• Metaxalone
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methadone
• Methamphetamine
• Methocarbamol
• Methohexital
• Methyclothiazide
• Methyldopa
• Methylergonovine
• Methylphenidate
• Methylprednisolone
• Methysergide
• Metoclopramide
• Metolazone
• Metoprolol
• Metyrapone
• Metyrosine
• Midazolam
• Midodrine
• Miglitol
• Minocycline
• Mirabegron
• Mirtazapine
• Mitotane
• Molindone
• Mometasone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nadolol
• Nafarelin
• Nalbuphine
• Naproxen; Pseudoephedrine
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nicardipine
• Nicotine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrates
• Non-Ionic Contrast Media
• Olanzapine
• Ombitasvir; Paritaprevir; Ritonavir
• Opiate Agonists
• Oritavancin
• Orphenadrine
• Oxazepam
• Oxycodone
• Oxymorphone
• Oxytocin
• Ozanimod
• Paliperidone
• Paromomycin
• Paroxetine
• Peginterferon Alfa-2b
• Penbutolol
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Pergolide
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phendimetrazine
• Phenelzine
• Phenobarbital
• Phenothiazines
• Phenoxybenzamine
• Phentermine
• Phentermine; Topiramate
• Phentolamine
• Phenylephrine; Promethazine
• Phosphodiesterase inhibitors
• Pimozide
• Pindolol
• Pioglitazone
• Pirbuterol
• Pitolisant
• Plazomicin
• Potassium-sparing diuretics
• Pramipexole
• Pramlintide
• Prazosin
• Prednisolone
• Prednisone
• Pregabalin
• Prilocaine; Epinephrine
• Primidone
• Procarbazine
• Prochlorperazine
• Promethazine
• Propofol
• Propoxyphene
• Propranolol
• Pseudoephedrine
• Quazepam
• Quetiapine
• Racepinephrine
• Ramelteon
• Rasagiline
• Remifentanil
• Reserpine
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• Safinamide
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• Selegiline
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• SGLT2 Inhibitors
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