Chlorpheniramine Codeine

Chlorpheniramine Codeine Brand Names

• Codeprex Pennkinetic
• Cotab A
• Cotab AX
• EndaCof-C
• Notuss AC
• TL-HIST CM
• Tuxarin ER
• TUZISTRA XR
• Zodryl AC
• Zodryl AC Adult
• Z-Tuss AC

What is Chlorpheniramine Codeine

Chlorpheniramine codeine is an antihistamine-antitussive combination product.

These products are used to provide temporary relief from rhinorrhea, sneezing, itching of the nose or throat, or itchy watery eyes due to hay fever, upper respiratory allergies, or allergic rhinitis, and cough as may occur from throat irritants or the common cold.

Chlorpheniramine is a sedating antihistamine (H1-blocker) of the alkylamine class. Codeine is an oral, semisynthetic opiate agonist with antitussive effects achieved at lower doses than doses required to produce analgesia.

Codeine is a prodrug that is hepatically metabolized to morphine.

Codeine metabolism is highly variable and unpredictable, particularly in children younger than 12 years; therapeutic response to recommended doses can range from lack of effect in poor metabolizers to fatality in ultra-rapid metabolizers.

Opioid cough and cold medicines that contain codeine are not indicated in pediatric patients under 18 years of age.

These products are contraindicated in neonates, infants and children less than 12 years of age; risks of opioid-containing cough and cold medicines outweigh their benefits in patients younger than 18 years.

Chlorpheniramine; codeine is also contraindicated in adolescent pediatric patients 12 to 18 years of age after tonsillectomy or adenoidectomy.

Indications of Chlorpheniramine Codeine

1. Allergic rhinitis
2. common cold
3. cough
4. sneezing

For the temporary relief of cough and upper respiratory symptoms (e.g., rhinorrhea, sneezing, itching of the nose or throat or itchy, watery eyes) associated with allergy (allergic rhinitis) or the common cold

Side Effects of Chlorpheniramine Codeine

1. abdominal pain
2. agitation
3. agranulocytosis
4. anaphylactoid reactions
5. anorexia
6. aplastic anemia
7. appetite stimulation
8. asthenia
9. biliary obstruction
10. blurred vision
11. bradycardia
12. bronchospasm
13. confusion
14. constipation
15. cyanosis
16. depression
17. diarrhea
18. dizziness
19. drowsiness
20. dyskinesia
21. dyspepsia
22. dyspnea
23. dysuria
24. erythema
25. euphoria
26. excitability
27. fever
28. flushing
29. gastroesophageal reflux
30. glycosuria
31. gynecomastia
32. headache
33. hyperamylasemia
34. hypertension
35. hypoglycemia
36. hypotension
37. ileus
38. impaired cognition
39. increased intracranial pressure
40. increased urinary frequency
41. insomnia
42. irritability
43. lacrimation
44. lactation suppression
45. libido increase
46. menstrual irregularity
47. miosis
48. mydriasis
49. nausea
50. neonatal opioid withdrawal syndrome
51. neonatal respiratory depression
52. ocular hypertension
53. orthostatic hypotension
54. palpitations
55. pancreatitis
56. photophobia
57. physiological dependence
58. pruritus
59. psychological dependence
60. pulmonary edema
61. rash
62. respiratory arrest
63. respiratory depression
64. restlessness
65. seizures
66. sinus tachycardia
67. syncope
68. thrombocytopenia
69. tinnitus
70. tremor
71. urinary retention
72. urticaria
73. vertigo
74. visual impairment
75. vomiting
76. weakness
77. withdrawal
78. xerophthalmia
79. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications of Chlorpheniramine Codeine

• abrupt discontinuation
• accidental exposure
• acute abdomen
• adenoidectomy
• adrenal insufficiency
• alcoholism
• Asian patients
• asthma
• biliary tract disease
• Black patients
• bladder obstruction
• brain tumor
• breast-feeding
• cardiac disease
• Caucasian patients
• children
• chronic obstructive pulmonary disease (COPD)
• closed-angle glaucoma
• coadministration with other CNS depressants
• coma
• constipation
• contact lenses
• cor pulmonale
• dehydration
• depression
• diarrhea
• driving or operating machinery
• ethanol ingestion
• ethanol intoxication
• gallbladder disease
• geriatric
• GI disease
• GI obstruction
• head trauma
• hepatic disease
• Hispanic patients
• hypotension
• hypothyroidism
• hypovolemia
• hypoxemia
• ileus
• increased intracranial pressure
• infants
• inflammatory bowel disease
• labor
• MAOI therapy
• myxedema
• neonatal opioid withdrawal syndrome
• neonates
• neuromuscular disease
• obesity
• obstetric delivery
• opiate agonist hypersensitivity
• orthostatic hypotension
• pancreatitis
• poor metabolizers
• potential for overdose or poisoning
• pregnancy
• prostatic hypertrophy
• pulmonary disease
• renal failure
• renal impairment
• respiratory depression
• respiratory infection
• respiratory insufficiency
• scoliosis
• seizure disorder
• seizures
• shock
• sleep apnea
• status asthmaticus
• substance abuse
• syncope
• tonsillectomy
• ulcerative colitis
• urethral stricture
• urinary retention

Interactions of Chlorpheniramine Codeine

• Abiraterone
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Acrivastine; Pseudoephedrine
• Aldesleukin, IL-2
• Alfentanil
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Almotriptan
• Alosetron
• Alprazolam
• Alvimopan
• Amantadine
• Ambenonium Chloride
• Amide local anesthetics
• Amifampridine
• Amikacin
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminoglycosides
• Amiodarone
• Amitriptyline
• Amitriptyline; Chlordiazepoxide
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Amobarbital
• Amoxapine
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amphetamine
• Amphetamine; Dextroamphetamine
• Amphetamine; Dextroamphetamine Salts
• Anticholinergics
• Apalutamide
• Apomorphine
• Apraclonidine
• Aprepitant, Fosaprepitant
• Aripiprazole
• Artemether; Lumefantrine
• Articaine; Epinephrine
• Asenapine
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Carisoprodol
• Aspirin, ASA; Carisoprodol; Codeine
• Aspirin, ASA; Oxycodone
• Atazanavir
• Atazanavir; Cobicistat
• Atenolol; Chlorthalidone
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Difenoxin
• Atropine; Diphenoxylate
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azelastine
• Azelastine; Fluticasone
• Azilsartan; Chlorthalidone
• Baclofen
• Barbiturates
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Belladonna; Opium
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Benzodiazepines
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Benzonatate
• Benzphetamine
• Bethanechol
• Bexarotene
• Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bosentan
• Brexpiprazole
• Brigatinib
• Brimonidine
• Brimonidine; Brinzolamide
• Brimonidine; Timolol
• Brompheniramine
• Brompheniramine; Carbetapentane; Phenylephrine
• Brompheniramine; Dextromethorphan; Guaifenesin
• Brompheniramine; Guaifenesin; Hydrocodone
• Brompheniramine; Hydrocodone; Pseudoephedrine
• Brompheniramine; Pseudoephedrine
• Bumetanide
• Bupivacaine
• Bupivacaine Liposomal
• Bupivacaine; Lidocaine
• Buprenorphine
• Buprenorphine; Naloxone
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Butabarbital
• Butorphanol
• Candesartan; Hydrochlorothiazide, HCTZ
• Cannabidiol
• Capsaicin; Metaxalone
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbetapentane; Chlorpheniramine
• Carbetapentane; Chlorpheniramine; Phenylephrine
• Carbetapentane; Diphenhydramine; Phenylephrine
• Carbetapentane; Guaifenesin
• Carbetapentane; Guaifenesin; Phenylephrine
• Carbetapentane; Phenylephrine
• Carbetapentane; Phenylephrine; Pyrilamine
• Carbetapentane; Pseudoephedrine
• Carbetapentane; Pyrilamine
• Carbidopa; Levodopa; Entacapone
• Carbinoxamine
• Carbinoxamine; Dextromethorphan; Pseudoephedrine
• Carbinoxamine; Hydrocodone; Phenylephrine
• Carbinoxamine; Hydrocodone; Pseudoephedrine
• Carbinoxamine; Phenylephrine
• Carbinoxamine; Pseudoephedrine
• Cariprazine
• Carisoprodol
• Celecoxib
• Cenobamate
• Ceritinib
• Cetirizine
• Cetirizine; Pseudoephedrine
• Chlophedianol; Dexbrompheniramine
• Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
• Chloral Hydrate
• Chloramphenicol
• Chlorcyclizine
• Chlordiazepoxide
• Chlordiazepoxide; Clidinium
• Chloroprocaine
• Chlorothiazide
• Chlorpheniramine; Dextromethorphan
• Chlorpheniramine; Dextromethorphan; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Phenylephrine
• Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
• Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
• Chlorpheniramine; Hydrocodone
• Chlorpheniramine; Hydrocodone; Phenylephrine
• Chlorpheniramine; Hydrocodone; Pseudoephedrine
• Chlorpromazine
• Chlorthalidone
• Chlorthalidone; Clonidine
• Chlorzoxazone
• Cimetidine
• Cinacalcet
• Ciprofloxacin
• Citalopram
• Clarithromycin
• Clemastine
• Clobazam
• Clomipramine
• Clonazepam
• Clonidine
• Clopidogrel
• Clorazepate
• Clozapine
• Cobicistat
• Codeine
• Codeine; Guaifenesin
• Codeine; Phenylephrine; Promethazine
• Codeine; Promethazine
• COMT inhibitors
• Conivaptan
• Crizotinib
• Crofelemer
• Cyclizine
• Cyclobenzaprine
• Cyclosporine
• Cyproheptadine
• Dabrafenib
• Dacomitinib
• Dalfopristin; Quinupristin
• Danazol
• Dantrolene
• Daratumumab; Hyaluronidase
• Darifenacin
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Delavirdine
• Desflurane
• Desipramine
• Desloratadine
• Desloratadine; Pseudoephedrine
• Desmopressin
• Desvenlafaxine
• Deutetrabenazine
• Dexamethasone
• Dexchlorpheniramine
• Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
• Dexmedetomidine
• Dexpanthenol
• Dextroamphetamine
• Dextromethorphan
• Dextromethorphan; Diphenhydramine; Phenylephrine
• Dextromethorphan; Guaifenesin
• Dextromethorphan; Guaifenesin; Phenylephrine
• Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
• Dextromethorphan; Guaifenesin; Pseudoephedrine
• Dextromethorphan; Promethazine
• Dextromethorphan; Quinidine
• Diazepam
• Dihydrocodeine; Guaifenesin; Pseudoephedrine
• Diltiazem
• Dimenhydrinate
• Diphenhydramine
• Diphenhydramine; Hydrocodone; Phenylephrine
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Diphenhydramine; Phenylephrine
• Disopyramide
• Dolasetron
• Donepezil
• Donepezil; Memantine
• Doxepin
• Doxorubicin
• Doxylamine
• Doxylamine; Pyridoxine
• Dronabinol
• Dronedarone
• Droperidol
• Duloxetine
• Dutasteride; Tamsulosin
• Efavirenz
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elagolix
• Elagolix; Estradiol; Norethindrone acetate
• Elbasvir; Grazoprevir
• Eletriptan
• Eliglustat
• Eltrombopag
• Eluxadoline
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Entacapone
• Enzalutamide
• Eprosartan; Hydrochlorothiazide, HCTZ
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Esketamine
• Eslicarbazepine
• Estazolam
• Eszopiclone
• Ethacrynic Acid
• Ethanol
• Ethotoin
• Etomidate
• Etravirine
• Everolimus
• Ezogabine
• Fedratinib
• Fentanyl
• Fesoterodine
• Flibanserin
• Fluconazole
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluphenazine
• Flurazepam
• Fluvoxamine
• Fosamprenavir
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Fospropofol
• Fostamatinib
• Frovatriptan
• Furosemide
• Gabapentin
• Galantamine
• General anesthetics
• Gentamicin
• Givosiran
• Granisetron
• grapefruit juice
• Guaifenesin; Hydrocodone
• Guaifenesin; Hydrocodone; Pseudoephedrine
• Guanabenz
• Guanfacine
• Halogenated Anesthetics
• Haloperidol
• Halothane
• Heparin
• Homatropine; Hydrocodone
• Hyaluronidase
• Hyaluronidase, Recombinant; Immune Globulin
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone
• Hydrocodone; Ibuprofen
• Hydrocodone; Phenylephrine
• Hydrocodone; Potassium Guaiacolsulfonate
• Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
• Hydrocodone; Pseudoephedrine
• Hydromorphone
• Hydroxyzine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibuprofen; Oxycodone
• Idelalisib
• Iloperidone
• Imatinib
• Imipramine
• Indapamide
• Indinavir
• Isavuconazonium
• Isocarboxazid
• Isoflurane
• Isoniazid, INH
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Istradefylline
• Itraconazole
• Kanamycin
• Ketamine
• Ketoconazole
• Lapatinib
• Larotrectinib
• Lasmiditan
• Lefamulin
• Lemborexant
• Letermovir
• Levobupivacaine
• Levocetirizine
• Levomethadyl
• Levomilnacipran
• Levorphanol
• Lidocaine
• Lidocaine; Prilocaine
• Lincosamides
• Linezolid
• Lithium
• Lofexidine
• Loop diuretics
• Loperamide
• Loperamide; Simethicone
• Lopinavir; Ritonavir
• Loratadine
• Loratadine; Pseudoephedrine
• Lorazepam
• Lorlatinib
• Loxapine
• Lumacaftor; Ivacaftor
• Lumateperone
• Lurasidone
• Magnesium Salts
• Maprotiline
• Meclizine
• Melatonin
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Mepivacaine
• Mepivacaine; Levonordefrin
• Meprobamate
• Metaxalone
• Methadone
• Methamphetamine
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methocarbamol
• Methohexital
• Methyclothiazide
• Methyldopa
• Methylene Blue
• Metoclopramide
• Metolazone
• Metyrapone
• Metyrosine
• Midazolam
• Mifepristone
• Milnacipran
• Minocycline
• Mirabegron
• Mirtazapine
• Mitotane
• Modafinil
• Molindone
• Monoamine oxidase inhibitors
• Morphine
• Morphine; Naltrexone
• Nabilone
• Nafcillin
• Nalbuphine
• Naloxone
• Naltrexone
• Naproxen; Sumatriptan
• Naratriptan
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nelfinavir
• Nesiritide, BNP
• Netupitant, Fosnetupitant; Palonosetron
• Nevirapine
• Nilotinib
• Nitroglycerin
• Nortriptyline
• Octreotide
• Olanzapine
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Ondansetron
• Opiate Agonists
• Oritavancin
• Orphenadrine
• Osilodrostat
• Oxazepam
• Oxycodone
• Oxymorphone
• Ozanimod
• Palbociclib
• Paliperidone
• Palonosetron
• Panobinostat
• Papaverine
• Paromomycin
• Paroxetine
• Peginterferon Alfa-2b
• Pegvisomant
• Pentazocine
• Pentazocine; Naloxone
• Pentobarbital
• Perampanel
• Perindopril; Amlodipine
• Perphenazine
• Perphenazine; Amitriptyline
• Phenelzine
• Phenobarbital
• Phenylephrine; Promethazine
• Phenytoin
• Pimozide
• Pitolisant
• Plazomicin
• Posaconazole
• Potassium-sparing diuretics
• Pramipexole
• Pramlintide
• Prasugrel
• Pregabalin
• Prilocaine
• Prilocaine; Epinephrine
• Primidone
• Procarbazine
• Prochlorperazine
• Promethazine
• Propafenone
• Propofol
• Propoxyphene
• Protriptyline
• Quazepam
• Quetiapine
• Quinidine
• Quinine
• Ramelteon
• Ranolazine
• Rasagiline
• Remifentanil
• Ribociclib
• Ribociclib; Letrozole
• Rifabutin
• Rifampin
• Rifapentine
• Rifaximin
• Risperidone
• Ritonavir
• Rituximab; Hyaluronidase
• Rivastigmine
• Rizatriptan
• Rolapitant
• Ropinirole
• Ropivacaine
• Rotigotine
• Rucaparib
• Safinamide
• Saquinavir
• Secobarbital
• Selegiline
• Selpercatinib
• Serotonin-Receptor Agonists
• Serotonin-Receptor Antagonists
• Sertraline
• Sevoflurane
• Sildenafil
• Sincalide
• Skeletal Muscle Relaxants
• Sodium Iodide
• Sodium Oxybate
• Solifenacin
• Spironolactone
• St. John’s Wort, Hypericum perforatum
• Streptogramins
• Streptomycin
• Sufentanil
• Sumatriptan
• Suvorexant
• Tacrine
• Tamsulosin
• Tapentadol
• Tasimelteon
• Tazemetostat
• Telithromycin
• Telotristat Ethyl
• Temazepam
• Terbinafine
• Tetrabenazine
• Tetracaine
• Thalidomide
• Thiazide diuretics
• Thiopental
• Thioridazine
• Thiothixene
• Ticagrelor
• Tipranavir
• Tizanidine
• Tobramycin
• Tolcapone
• Tolterodine
• Torsemide
• Tramadol
• Trandolapril; Verapamil
• Tranylcypromine
• Trastuzumab; Hyaluronidase
• Trazodone
• Triamterene
• Triazolam
• Tricyclic antidepressants
• Trifluoperazine
• Trimethobenzamide
• Trimipramine
• Triprolidine
• Trospium
• Tucatinib
• Valerian, Valeriana officinalis
• Valproic Acid, Divalproex Sodium
• Vemurafenib
• Venlafaxine
• Verapamil
• Vigabatrin
• Vilazodone
• Voriconazole
• Vortioxetine
• Voxelotor
• Zaleplon
• Ziconotide
• Ziprasidone
• Zolmitriptan
• Zolpidem