Celecoxib Brand Names
Celebrex | ELYXYB
What is Celecoxib
Celecoxib is an oral nonsteroidal anti-inflammatory drug (NSAID), a selective cyclooxygenase-2 (COX-2) inhibitor, indicated for osteoarthritis, rheumatoid arthritis, juvenile rheumatoid arthritis (JRA), ankylosing spondylitis, primary dysmenorrhea, acute pain, and migraine with or without aura.
All NSAIDs, including naproxen, cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and GI perforation of the esophagus, stomach, small intestine, or large intestine and are associated with an increased risk of serious cardiovascular (CV) thromboembolism, including myocardial infarction or stroke.
Use the lowest effective dose for the shortest possible duration; the increase in CV risk has been most consistently observed at higher doses.
Indications
- ankylosing spondylitis
- dysmenorrhea
- juvenile rheumatoid arthritis (JRA)/juvenile idiopathic arthritis (JIA)
- migraine
- moderate pain
- osteoarthritis
- polyarticular juvenile idiopathic arthritis
- rheumatoid arthritis
- severe pain
For the relief of the signs and symptoms of osteoarthritis
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- alopecia
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anorexia
- anosmia
- anxiety
- aplastic anemia
- arthralgia
- aseptic meningitis
- ataxia
- azotemia
- back pain
- bradycardia
- bronchospasm
- chest pain (unspecified)
- cholelithiasis
- colitis
- constipation
- contact dermatitis
- cough
- cyanosis
- cystitis
- depression
- diaphoresis
- diarrhea
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- dysgeusia
- dyspepsia
- dysphagia
- dyspnea
- dysuria
- ecchymosis
- edema
- elevated hepatic enzymes
- epistaxis
- eructation
- erythema
- erythema multiforme
- esophageal stricture
- esophageal ulceration
- esophagitis
- exfoliative dermatitis
- fever
- flatulence
- gastritis
- gastroesophageal reflux
- GI bleeding
- GI obstruction
- GI perforation
- headache
- hearing loss
- heart failure
- hematuria
- hemorrhoids
- hepatic failure
- hepatitis
- hot flashes
- hypercholesterolemia
- hyperglycemia
- hyperkalemia
- hypernatremia
- hypertension
- hypertonia
- hypoesthesia
- hypoglycemia
- hypokalemia
- hyponatremia
- ileus
- increased urinary frequency
- infection
- infertility
- insomnia
- interstitial nephritis
- intracranial bleeding
- jaundice
- laryngitis
- leukopenia
- maculopapular rash
- melena
- methemoglobinemia
- migraine
- muscle cramps
- myalgia
- myocardial infarction
- nausea
- nephrolithiasis
- odynophagia
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- peptic ulcer
- peripheral edema
- pharyngitis
- phlebitis
- photosensitivity
- proteinuria
- pruritus
- pulmonary embolism
- pyrosis (heartburn)
- rash
- renal failure (unspecified)
- renal papillary necrosis
- rhinitis
- sinus tachycardia
- sinusitis
- Stevens-Johnson syndrome
- stomatitis
- stroke
- syncope
- synovitis
- tendon rupture
- tenesmus
- thrombocytopenia
- thromboembolism
- thrombosis
- tinnitus
- toxic epidermal necrolysis
- urticaria
- vasculitis
- ventricular fibrillation
- vertigo
- vomiting
- weight gain
- xerosis
- xerostomia
Monitoring Parameters
- blood pressure
- CBC
- LFTs
- serum creatinine/BUN
Contraindications
- acute bronchospasm
- acute myocardial infarction
- angina
- anticoagulant therapy
- asthma
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- cerebrovascular disease
- children
- coagulopathy
- coronary artery bypass graft surgery (CABG)
- coronary artery disease
- dehydration
- ethanol ingestion
- geriatric
- GI bleeding
- GI perforation
- heart failure
- hepatic disease
- hypertension
- hypovolemia
- infection
- infertility
- labor
- myocardial infarction
- myocardial infarction or stroke
- nasal polyps
- NSAID hypersensitivity
- obstetric delivery
- peptic ulcer disease
- peripheral vascular disease
- pregnancy
- renal disease
- renal failure
- renal impairment
- reproductive risk
- salicylate hypersensitivity
- serious rash
- stroke
- sulfonamide hypersensitivity
- tachycardia
- thromboembolism
- tobacco smoking
- urticaria
Interactions
- Abciximab
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Tramadol
- Acetohexamide
- Acyclovir
- Adefovir
- Aldesleukin, IL-2
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alpelisib
- Alpha-blockers
- Alteplase
- Altretamine
- Ambenonium Chloride
- Amikacin
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Benazepril
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxapine
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Anagrelide
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Antithrombin III
- Antithymocyte Globulin
- Apalutamide
- Apixaban
- Aprepitant, Fosaprepitant
- Aprotinin
- Argatroban
- Aripiprazole
- Arsenic Trioxide
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Edrophonium
- Azathioprine
- Azelastine; Fluticasone
- Azilsartan
- Azilsartan; Chlorthalidone
- Bacitracin
- Balsalazide
- Beclomethasone
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Beta-blockers
- Betamethasone
- Betaxolol
- Betrixaban
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bisphosphonates
- Bivalirudin
- Brexpiprazole
- Brimonidine; Timolol
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bumetanide
- Busulfan
- Calcium Phosphate, Supersaturated
- Calcium-channel blockers
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capreomycin
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carmustine, BCNU
- Carteolol
- Carvedilol
- Cefotaxime
- Cevimeline
- Chlorambucil
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpropamide
- Chlorthalidone; Clonidine
- Choline Salicylate; Magnesium Salicylate
- Cholinesterase inhibitors
- Ciclesonide
- Cidofovir
- Cilostazol
- Cimetidine
- Citalopram
- Cladribine
- Clofarabine
- Clomipramine
- Clonidine
- Clopidogrel
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- Colistimethate, Colistin, Polymyxin E
- Corticosteroids
- Cortisone
- Cyclosporine
- Cytarabine, ARA-C
- Dabigatran
- Dabrafenib
- Dacarbazine, DTIC
- Dactinomycin, Actinomycin D
- Dalteparin
- Danaparoid
- Darifenacin
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasatinib
- Decitabine
- Deferasirox
- Deflazacort
- Delavirdine
- Desipramine
- Desirudin
- Desmopressin
- Desvenlafaxine
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazoxide
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dipyridamole
- Docetaxel
- Dolasetron
- Donepezil
- Donepezil; Memantine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dorzolamide; Timolol
- Doxazosin
- Doxepin
- Doxorubicin
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Drotrecogin Alfa
- Duloxetine
- Edoxaban
- Edrophonium
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Encainide
- Enoxaparin
- Entecavir
- Enzalutamide
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Eptifibatide
- Erlotinib
- Escitalopram
- Esmolol
- Esomeprazole; Naproxen
- Ethacrynic Acid
- Ethanol
- Etodolac
- Famotidine; Ibuprofen
- Fenofibric Acid
- Fenoldopam
- Fenoprofen
- Flavocoxid, Flavocoxid; Citrated Zinc Bisglycinate
- Flecainide
- Floxuridine
- Fluconazole
- Fludrocortisone
- Flunisolide
- Fluorouracil, 5-FU
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvoxamine
- Fondaparinux
- Formoterol; Mometasone
- Foscarnet
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
- Gadoterate meglumine
- Galantamine
- Gallium Ga 68 Dotatate
- Ganciclovir
- Garlic, Allium sativum
- Gentamicin
- Ginger, Zingiber officinale
- Ginkgo, Ginkgo biloba
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Gold
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanabenz
- Guanfacine
- Haloperidol
- Heparin
- Homatropine; Hydrocodone
- Hyaluronidase, Recombinant; Immune Globulin
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibritumomab Tiuxetan
- Ibuprofen
- Ibuprofen lysine
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloprost
- Imipramine
- Immune Globulin IV, IVIG, IGIV
- Indapamide
- Indomethacin
- Inotersen
- Iodipamide Meglumine
- Iohexol
- Ionic Contrast Media
- Iopamidol
- Iopromide
- Ioversol
- Ioxaglate Meglumine; Ioxaglate Sodium
- Irbesartan
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isosulfan Blue
- Ivacaftor
- Ivosidenib
- Kanamycin
- Ketoconazole
- Ketoprofen
- Ketorolac
- Labetalol
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole; Naproxen
- Leflunomide
- Lepirudin
- Levobetaxolol
- Levobunolol
- Levomilnacipran
- Lisinopril
- Lithium
- Lofexidine
- Lomustine, CCNU
- Losartan
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Macimorelin
- Magnesium Salicylate
- Magnesium Salts
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Mannitol
- Maprotiline
- Mecamylamine
- Mechlorethamine, Nitrogen Mustard
- Meclizine
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Melphalan
- Meperidine; Promethazine
- Mesalamine, 5-ASA
- Methadone
- Methamphetamine
- Methotrexate
- Methyldopa
- Methylprednisolone
- Methylsulfonylmethane, MSM
- Metoclopramide
- Metoprolol
- Metronidazole
- Mexiletine
- Mifepristone
- Milnacipran
- Minoxidil
- Mitomycin
- Mitoxantrone
- Moexipril
- Mometasone
- Muromonab-CD3
- Nabumetone
- Nadolol
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol
- Nebivolol; Valsartan
- Nelarabine
- Neomycin
- Neostigmine
- Nitisinone
- Nitroprusside
- Non-Ionic Contrast Media
- Nortriptyline
- Olmesartan
- Olsalazine
- Omacetaxine
- Ondansetron
- Oritavancin
- Oxaprozin
- Paclitaxel
- Paroxetine
- Pegaspargase
- Penbutolol
- Pentamidine
- Pentosan
- Pentostatin
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phenoxybenzamine
- Phentermine; Topiramate
- Phentolamine
- Phenylephrine; Promethazine
- Photosensitizing agents (topical)
- Physostigmine
- Pimozide
- Pindolol
- Piroxicam
- Platelet Inhibitors
- Pneumococcal Vaccine, Polyvalent
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Polymyxin B
- Polymyxins
- Potassium
- Pralatrexate
- Prasugrel
- Prazosin
- Prednisolone
- Prednisone
- Probenecid
- Procarbazine
- Promethazine
- Propafenone
- Propranolol
- Protriptyline
- Pyridostigmine
- Quinapril
- Quinolones
- Ramipril
- Reserpine
- Reteplase, r-PA
- Rifampin
- Rivaroxaban
- Rivastigmine
- Rucaparib
- Sacubitril; Valsartan
- Salsalate
- Selective serotonin reuptake inhibitors
- Sertraline
- Sodium Hyaluronate, Hyaluronic Acid
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sotalol
- Spironolactone
- Streptokinase
- Streptomycin
- Streptozocin
- Sulfasalazine
- Sulfinpyrazone
- Sulfonylureas
- Sulindac
- Tacrine
- Tacrolimus
- Telavancin
- Telbivudine
- Telmisartan
- Temozolomide
- Tenecteplase
- Teniposide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Terazosin
- Tezacaftor; Ivacaftor
- Thiazide diuretics
- Thioguanine, 6-TG
- Thioridazine
- Thrombolytic Agents
- Ticagrelor
- Ticlopidine
- Timolol
- Tinzaparin
- Tirofiban
- Tobramycin
- Tolazamide
- Tolbutamide
- Tolmetin
- Tolterodine
- Topiramate
- Torsemide
- Tositumomab
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Trazodone
- Treprostinil
- Triamcinolone
- Triamterene
- Trimipramine
- Urea
- Urokinase
- Valacyclovir
- Valganciclovir
- Valsartan
- Vancomycin
- Vasodilators
- Venlafaxine
- Verteporfin
- Vilazodone
- Vinblastine
- Vorapaxar
- Voriconazole
- Vorinostat
- Vortioxetine
- Warfarin
- Zafirlukast
