Cemiplimab

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Cemiplimab Brand Name– LIBTAYO

What is Cemiplimab

Cemiplimab is a programmed death receptor-1 (PD-1) blocking antibody indicated for the treatment of adult patients with metastatic cutaneous squamous cell carcinoma (CSCC) or locally advanced CSCC in patients who are not candidates for curative surgery or radiation.

Immune-mediated adverse reactions including colitis, pneumonitis, hepatitis, endocrinopathies, and nephritis have been reported with cemiplimab therapy; treatment with high-dose corticosteroids may be necessary in patients who develop immune-mediated toxicity.

Indications

  • squamous cell skin carcinoma

For the treatment of squamous cell skin carcinoma

for the treatment of metastatic cutaneous squamous cell carcinoma (CSCC) or locally advanced CSCC in patients who are not candidates for curative surgery or curative radiation

Side Effects

  1. adrenocortical insufficiency
  2. adrenocortical insufficiency
  3. anemia
  4. anorexia
  5. antibody formation
  6. aplastic anemia
  7. asthenia
  8. asthenia
  9. back pain
  10. back pain
  11. bullous rash
  12. bullous rash
  13. colitis
  14. colitis
  15. constipation
  16. constipation
  17. diabetes mellitus
  18. diabetic ketoacidosis
  19. diarrhea
  20. diarrhea
  21. elevated hepatic enzymes
  22. erythema
  23. erythema
  24. erythema multiforme
  25. fatigue
  26. fatigue
  27. gastritis
  28. Guillain-Barre syndrome
  29. hemolytic anemia
  30. hemophagocytic lymphohistiocytosis
  31. hepatitis
  32. hyperamylasemia
  33. hypercalcemia
  34. hypertension
  35. hyperthyroidism
  36. hyperthyroidism
  37. hypoalbuminemia
  38. hyponatremia
  39. hypophosphatemia
  40. hypophysitis
  41. hypothyroidism
  42. hypothyroidism
  43. infection
  44. infusion-related reactions
  45. interstitial nephritis
  46. iritis
  47. lymphopenia
  48. maculopapular rash
  49. maculopapular rash
  50. meningitis
  51. musculoskeletal pain
  52. musculoskeletal pain
  53. myalgia
  54. myalgia
  55. myasthenia gravis
  56. myelitis
  57. myocarditis
  58. nausea
  59. ocular inflammation
  60. organ transplant rejection
  61. pancreatitis
  62. paresis
  63. pericarditis
  64. pneumonitis
  65. pneumonitis
  66. pruritus
  67. purpura
  68. rash
  69. rash
  70. renal failure (unspecified)
  71. retinal detachment
  72. rhabdomyolysis
  73. uveitis
  74. Vogt-Koyanagi-Harada syndrome
  75. weakness

Monitoring Parameters

  • blood glucose
  • LFTs
  • pregnancy testing
  • serum creatinine/BUN
  • thyroid function tests (TFTs)

Contraindications

  • adrenal insufficiency
  • autoimmune disease
  • breast-feeding
  • colitis
  • contraception requirements
  • Crohn’s disease
  • hepatitis
  • hyperthyroidism
  • hypophysitis
  • hypothyroidism
  • immune-mediated reactions
  • inflammatory bowel disease
  • infusion-related reactions
  • organ transplant
  • pneumonitis
  • pregnancy
  • pregnancy testing
  • renal impairment
  • reproductive risk
  • serious rash
  • type 1 diabetes mellitus
  • ulcerative colitis

Interactions

  • Palifermin
  • Penicillamine
  • Tuberculin Purified Protein Derivative, PPD

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