Ceftriaxone Brand Name– Ceftrisol Plus | Rocephin
What is Ceftriaxone
Ceftriaxone is a parenteral third-generation cephalosporin. Similar to other third-generation cephalosporins, ceftriaxone possesses significant activity against serious gram-negative organisms and also penetrates the CSF in concentrations that make it useful in the treatment of meningitis.
Ceftriaxone has the longest half-life of all cephalosporins, allowing for once-daily dosing and making it a useful antibiotic for outpatient therapy.
Ceftriaxone was approved by the FDA in December 1984.
Indications
- Acinetobacter calcoaceticus
- Actinomyces sp.
- appendicitis
- bacteremia
- bacterial colonization eradication
- bacterial conjunctivitis
- bacterial infection prophylaxis
- Bacteroides bivius
- Bacteroides fragilis
- biliary tract infections
- bone and joint infections
- Borrelia burgdorferi
- brain abscess
- chancroid
- cholecystitis
- Citrobacter diversus
- Citrobacter freundii
- Clostridium sp.
- community-acquired pneumonia
- diabetic foot ulcer
- Eikenella corrodens
- endocarditis
- endocarditis prophylaxis
- Enterobacter cloacae
- epididymitis
- Escherichia coli
- Fusobacterium sp.
- gastroenteritis
- gonorrhea
- gonorrhea prophylaxis
- Haemophilus ducreyi
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- infectious diarrhea
- intraabdominal infections
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Lactobacillus sp.
- Leptospira sp.
- leptospirosis
- lower respiratory tract infections
- Lyme disease
- meningitis
- meningococcal infection prophylaxis
- Moraxella catarrhalis
- Morganella morganii
- Neisseria gonorrhoeae
- Neisseria meningitidis
- neurosyphilis
- ophthalmia neonatorum
- ophthalmia neonatorum prophylaxis
- osteomyelitis
- otitis media
- pelvic inflammatory disease (PID)
- Peptococcus sp.
- Peptostreptococcus sp.
- pleural empyema
- pneumonia
- Prevotella melaninogenica
- Propionibacterium sp.
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Providencia sp.
- Salmonella sp.
- Salmonella typhi
- salmonellosis
- sepsis
- Serratia marcescens
- Shigella sp.
- sinusitis
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- surgical infection prophylaxis
- syphilis
- typhoid fever
- urinary tract infection (UTI)
- Veillonella sp.
- Viridans streptococci
- Yersinia enterocolitica
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agranulocytosis
- anaphylactoid reactions
- anemia
- angioedema
- aplastic anemia
- azotemia
- biliary obstruction
- bleeding
- bronchospasm
- candidiasis
- chills
- cholelithiasis
- cholestasis
- colitis
- diaphoresis
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- edema
- elevated hepatic enzymes
- eosinophilia
- epistaxis
- erythema multiforme
- fever
- flatulence
- flushing
- glossitis
- glycosuria
- headache
- hematuria
- hemolytic anemia
- hyperbilirubinemia
- hypertonia
- hypoprothrombinemia
- injection site reaction
- Jarisch-Herxheimer reaction
- jaundice
- leukocytosis
- leukopenia
- lymphocytosis
- lymphopenia
- nausea
- nephrolithiasis
- neutropenia
- oliguria
- palpitations
- pancreatitis
- phlebitis
- pneumonitis
- pruritus
- pseudomembranous colitis
- rash
- renal failure (unspecified)
- seizures
- serum sickness
- Stevens-Johnson syndrome
- stomatitis
- superinfection
- thrombocytopenia
- thrombocytosis
- toxic epidermal necrolysis
- urticaria
- vaginitis
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
- LFTs
Contraindications
- antimicrobial resistance
- breast-feeding
- cephalosporin hypersensitivity
- coadministration of calcium-containing IV’s
- coagulopathy
- colitis
- diarrhea
- gallbladder disease
- geriatric
- GI disease
- hepatic disease
- inflammatory bowel disease
- intramuscular injections
- jaundice
- neonates
- penicillin hypersensitivity
- pregnancy
- premature neonates
- pseudomembranous colitis
- renal failure
- sexually transmitted disease
- ulcerative colitis
- urinary tract obstruction
- viral infection
- vitamin K deficiency
Interactions
- Calcium Acetate
- Calcium Chloride
- Calcium Gluconate
- Cyclosporine
- Loop diuretics
- Oral Contraceptives
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Warfarin
