Cannabidiol Brand Name– EPIDIOLEX
What is Cannabidiol
Cannabidiol is an oral cannabinoid indicated for the treatment of seizures associated with Lennox-Gastaut syndrome and Dravet syndrome.
Cannabidiol is a marijuana derivative; however, it lacks the psychoactive properties that are commonly associated with delta-9-tetrahydrocannabinol (THC).
Cannabidiol significantly reduced seizure frequency in patients with Dravet syndrome and Lennox-Gastaut syndrome when added to other antiepileptic therapies during clinical trials. A reduction in seizures was observed within 4 weeks of treatment initiation for both forms of epilepsy.
In patients with Dravet syndrome, the median percentage reduction in monthly convulsive seizures from baseline was 39% for those receiving cannabidiol 20 mg/kg/day vs. 13% for those receiving placebo.
During the maintenance period, 6.7% of cannabidiol-treated patients were seizure free.
In patients with Lennox-Gastaut syndrome, the median percentage reduction in monthly drop seizure frequency from baseline was 37% for those receiving cannabidiol 10 mg/kg/day, 42% to 44% for those receiving 20 mg/kg/day, and 17% to 22% for those receiving placebo.
Somnolence, decreased appetite, and diarrhea are among the most common adverse reactions of cannabidiol. Dose-related elevations in liver transaminases can occur, and routine monitoring of hepatic enzymes is necessary
Indications
- Dravet syndrome
- Lennox-Gastaut syndrome
Side Effects
- abdominal pain
- agitation
- anemia
- angioedema
- anorexia
- asthenia
- depression
- diarrhea
- drowsiness
- elevated hepatic enzymes
- erythema
- fatigue
- hypersalivation
- hypoxia
- infection
- insomnia
- irritability
- lethargy
- malaise
- pruritus
- rash
- suicidal ideation
- weight loss
Monitoring Parameters
- LFTs
Contraindications
- abrupt discontinuation
- breast-feeding
- depression
- driving or operating machinery
- hepatic disease
- pregnancy
- sesame oil hypersensitivity
- suicidal ideation
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Diphenhydramine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
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- Amlodipine; Celecoxib
- Amobarbital
- Amoxapine
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- Anxiolytics; Sedatives; and Hypnotics
- Apalutamide
- Apomorphine
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- Aripiprazole
- Armodafinil
- Asenapine
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- Aspirin, ASA; Caffeine; Orphenadrine
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