Calcium Citrate

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Calcium Citrate Brand Name– Calcitrate

What is Calcium Citrate

Calcium citrate is an acidic calcium salt containing 21% elemental calcium. It is used for nutritional supplementation to maintain bone health and for the maintenance treatment of hypocalcemia.

Calcium is the most abundant cation and the fifth most common inorganic element in the human body. Calcium is essential for the maintenance of the nervous, muscular, and skeletal systems, and for cell membrane and capillary permeability.

Its role in bone structure and muscle contraction is well known, but calcium is also important for blood coagulation, nerve conduction, and electrical conduction in the myocardium. In general, calcium salts are used to treat or prevent calcium depletion.

Calcium is recognized as an important agent in preventing osteoporosis, especially in postmenopausal women.

Calcium citrate, due to its acidic base, is the supplement of choice for patients with achlorhydria because it requires less production of stomach acids, allowing better absorption.

Calcium citrate has been shown to be more bioavailable than calcium carbonate when given with meals.

Indications

  • hypocalcemia
  • nutritional supplementation
  • osteoporosis prophylaxis
  • Calcium citrate contains 21% elemental calcium, which is equivalent to 210 mg (10.5 mEq) of elemental calcium per gram of calcium citrate.

Side Effects

  1. anorexia
  2. coma
  3. confusion
  4. constipation
  5. delirium
  6. drowsiness
  7. hypercalcemia
  8. hypertension
  9. milk-alkali syndrome
  10. nausea
  11. nephrolithiasis
  12. polyuria
  13. premature ventricular contractions (PVCs)
  14. vomiting

Monitoring Parameters

  • serum albumin
  • serum calcium

Contraindications

  • breast-feeding
  • hypercalcemia
  • hypercalciuria
  • hyperparathyroidism
  • nephrolithiasis
  • pregnancy
  • renal failure
  • sarcoidosis
  • vitamin D toxicity

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Atenolol
  • Atenolol; Chlorthalidone
  • Azilsartan; Chlorthalidone
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Betamethasone; Calcipotriene
  • Bictegravir; Emtricitabine; Tenofovir Alafenamide
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bisphosphonates
  • Calcipotriene
  • Calcitonin
  • Calcium Phosphate, Supersaturated
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Captopril; Hydrochlorothiazide, HCTZ
  • Cardiac glycosides
  • Chlorothiazide
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Ciprofloxacin
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Delafloxacin
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Dolutegravir
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Edetate Calcium Disodium, Calcium EDTA
  • Edetate Disodium, Disodium EDTA
  • Elagolix; Estradiol; Norethindrone acetate
  • Eltrombopag
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estramustine
  • Estrogens
  • Estropipate
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethotoin
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Gallium
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Ibritumomab Tiuxetan
  • Levofloxacin
  • Mestranol; Norethindrone
  • Methyclothiazide
  • Metolazone
  • Moxifloxacin
  • Neuromuscular blockers
  • Norfloxacin
  • Ofloxacin
  • Omeprazole; Sodium Bicarbonate
  • Phosphorated Carbohydrate Solution
  • Phosphorus
  • Potassium Phosphate
  • Potassium Phosphate; Sodium Phosphate
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Bicarbonate
  • Sodium Fluoride
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Tetracyclines
  • Thiazide diuretics
  • Thyroid hormones
  • Trientine
  • Vitamin A
  • Vitamin D analogs

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