Calaspargase pegol Brand Name– ASPARLAS
What is Calaspargase pegol
Calaspargase pegol-mknl is an asparagine specific enzyme that is indicated in combination with multi-agent chemotherapy for the treatment of acute lymphoblastic leukemia in patients 1 month to 21 years of age.
Use of calaspargase pegol is contraindicated in patients with serious hypersensitivity reactions to pegylated L-asparaginase, serious thrombosis during L-asparaginase therapy, or serious pancreatitis related to previous L-asparaginase treatment.
Indications
- acute lymphocytic leukemia (ALL)
Side Effects
- anaphylactoid reactions
- AV block
- bleeding
- candidiasis
- colitis
- diarrhea
- disseminated intravascular coagulation (DIC)
- dyspnea
- elevated hepatic enzymes
- enterocolitis
- epistaxis
- GI bleeding
- heart failure
- hematoma
- hyperamylasemia
- hyperbilirubinemia
- hypoalbuminemia
- hypoxia
- infection
- infusion-related reactions
- intracranial bleeding
- pancreatitis
- pneumonitis
- prolonged bleeding time
- pulmonary embolism
- sinus tachycardia
- thromboembolism
- thrombosis
Monitoring Parameters
- blood glucose
- LFTs
- pregnancy testing
- serum amylase
- serum lipase
Contraindications
- bleeding
- breast-feeding
- coagulopathy
- contraception requirements
- hepatic disease
- hyperglycemia
- infusion-related reactions
- L-asparaginase hypersensitivity
- pancreatitis
- pregnancy
- pregnancy testing
- reproductive risk
- thromboembolism
- thrombosis
Interactions
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Leuprolide; Norethindrone
- Levonorgestrel
- Mestranol; Norethindrone
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Palifermin
- Penicillamine
- Segesterone Acetate; Ethinyl Estradiol
- Tuberculin Purified Protein Derivative, PPD
