Asparaginase Erwinia chrysanthemi

Asparaginase Erwinia chrysanthemi Brand Name– Erwinaze

What is Asparaginase Erwinia chrysanthemi

Asparaginase Erwinia chrysanthemi is an asparagine specific enzyme indicated in combination with multi-agent chemotherapy for the treatment of patients aged 1 year and older with acute lymphoblastic leukemia who have developed hypersensitivity to Escherichia (E.) coli-derived asparaginase.

Asparaginase Erwinia chrysanthemi may replace a dose of the modified version of E. coli L-asparaginase (pegaspargase) or a dose of native E. coli asparaginase (L-Asparaginase).

Asparaginase Erwinia chrysanthemi is contraindicated in patients with a history of serious hypersensitivity reactions to any component of the product or who have had serious pancreatitis, thrombosis, or bleeding events with prior L-asparaginase therapy.

Indications

  • acute lymphocytic leukemia (ALL)

For the treatment of acute lymphocytic leukemia (ALL) in combination with other chemotherapeutic agents in patients who have developed hypersensitivity to E. coli-derived asparaginase

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. antibody formation
  5. bleeding
  6. diarrhea
  7. disseminated intravascular coagulation (DIC)
  8. elevated hepatic enzymes
  9. fever
  10. headache
  11. hyperammonemia
  12. hyperbilirubinemia
  13. hyperglycemia
  14. injection site reaction
  15. nausea
  16. pancreatitis
  17. seizures
  18. thrombosis
  19. urticaria
  20. vomiting

Monitoring Parameters

  • blood glucose
  • pregnancy testing

Contraindications

  • bleeding
  • breast-feeding
  • children
  • contraception requirements
  • diabetes mellitus
  • hepatic disease
  • hyperglycemia
  • infants
  • pancreatitis
  • pregnancy
  • pregnancy testing
  • reproductive risk
  • thromboembolic disease

Interactions

  • Antithymocyte Globulin
  • Carbamazepine
  • Corticosteroids
  • Cytarabine, ARA-C
  • Methotrexate
  • Thyroid hormones
  • Vincristine
  • Vincristine Liposomal
  • Zonisamide
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