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Busulfan Brand Names
Busulfex | Myleran
What is Busulfan
Busulfan (1,4-butanediol dimethanesulfonate) is a bifunctional alkylating agent.
The IV formulation is indicated in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic stem-cell transplantation in patients with chronic myelogenous leukemia (CML).
The oral tablet formulation is indicated for the palliative treatment of CML. It is less effective in patients with Philadelphia chromosome (Ph)-negative CML and in young children with Ph-negative disease.
It is not effective for the treatment of blast-phase CML, chronic lymphocytic leukemia, or acute leukemias.
Indications
- chronic myelogenous leukemia (CML)
- stem cell transplant preparation
For the palliative treatment of chronic myelogenous leukemia (CML)
Side Effects
- abdominal pain
- acne vulgaris
- adrenocortical insufficiency
- agitation
- alopecia
- amenorrhea
- anemia
- anhidrosis
- anorexia
- anorexia
- anovulation
- anxiety
- aplastic anemia
- arthralgia
- asthenia
- atrial fibrillation
- azoospermia
- back pain
- bone marrow suppression
- bullous rash
- cardiac tamponade
- cataracts
- cheilitis
- chest pain (unspecified)
- chills
- coma
- confusion
- constipation
- cough
- delirium
- depression
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- dyspnea
- dysuria
- edema
- elevated hepatic enzymes
- enamel hypoplasia
- encephalopathy
- epistaxis
- erythema multiforme
- erythema nodosum
- esophagitis
- fever
- flushing
- gonadal suppression
- graft-versus-host disease (GVHD)
- gynecomastia
- hallucinations
- headache
- heart failure
- hematemesis
- hematuria
- hemoptysis
- hemorrhagic cystitis
- hepatic necrosis
- hepatomegaly
- hiccups
- hot flashes
- hyperbilirubinemia
- hyperbilirubinemia
- hyperglycemia
- hypertension
- hyperuricemia
- hyperventilation
- hypervolemia
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypophosphatemia
- hypotension
- hypoxia
- ileus
- infection
- infertility
- injection site reaction
- insomnia
- intracranial bleeding
- jaundice
- lethargy
- leukopenia
- lymphopenia
- maculopapular rash
- myalgia
- myasthenia
- nausea
- neutropenia
- new primary malignancy
- oliguria
- pancreatitis
- pericardial effusion
- pharyngitis
- pleural effusion
- porphyria
- prolonged bleeding time
- pruritus
- pulmonary fibrosis
- rash
- rhinitis
- seizures
- sinus tachycardia
- sinusitis
- sinusoidal obstruction syndrome (SOS)
- skin discoloration
- skin hyperpigmentation
- stomatitis
- testicular atrophy
- thrombocytopenia
- thrombosis
- thrombotic microangiopathy
- tumor lysis syndrome (TLS)
- urticaria
- veno-occlusive disease (VOD)
- vesicular rash
- vomiting
- weakness
- weight gain
- weight loss
- xerosis
- xerostomia
Monitoring Parameters
- CBC with differential
- LFTs
- serum bilirubin (total and direct)
- serum electrolytes
- serum uric acid
Contraindications
- bleeding
- bone marrow suppression
- breast-feeding
- children
- contraception requirements
- head trauma
- hepatic disease
- hepatotoxicity
- hyperuricemia
- infants
- infection
- infertility
- leukopenia
- male-mediated teratogenicity
- neonates
- neutropenia
- new primary malignancy
- pregnancy
- radiation therapy
- reproductive risk
- seizures
- sinusoidal obstruction syndrome (SOS)
- thrombocytopenia
- tumor lysis syndrome (TLS)
- vaccination
- veno-occlusive disease (VOD)
Interactions
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Aldesleukin, IL-2
- Amlodipine; Celecoxib
- Benzhydrocodone; Acetaminophen
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Celecoxib
- Clozapine
- Cyclophosphamide
- Deferasirox
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Echinacea
- Esomeprazole; Naproxen
- Ethotoin
- Etodolac
- Famotidine; Ibuprofen
- Febuxostat
- Fenoprofen
- Flucytosine
- Flurbiprofen
- Fosphenytoin
- Hydrocodone; Ibuprofen
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Itraconazole
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Live Vaccines
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Metronidazole
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Palifermin
- Pegfilgrastim
- Penicillamine
- Pexidartinib
- Phenytoin
- Piroxicam
- Riluzole
- Rofecoxib
- Rufinamide
- Sulindac
- Thioguanine, 6-TG
- Tolmetin
- Tuberculin Purified Protein Derivative, PPD
- Valdecoxib
