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Bromocriptine Brand Names
Cycloset | Parlodel
What is Bromocriptine
Bromocriptine is a synthetic dopamine agonist that is chemically related to ergot alkaloids and lysergic acid.
Bromocriptine is used in adult and pediatric patients 11 years and older with selected conditions.
It was the first dopamine agonist marketed for the treatment of Parkinson’s disease (PD) in adults as monotherapy or as an adjunct to levodopa-based treatment; however, newer dopamine agonists have largely replaced bromocriptine in the treatment of PD.
Bromocriptine is a versatile drug and is indicated for a variety of endocrine conditions including pituitary-secreting adenomas and hyperprolactinemia-related conditions (e.g., amenorrhea with or without galactorrhea, hypogonadism, or infertility).
Bromocriptine is also effective in patients with acromegaly, although newer agents directly targeting growth hormone have largely replaced bromocriptine in the treatment of patients with this condition.
A micronized tablet (Cycloset) has been approved for the treatment of type 2 diabetes mellitus in adults.
The American Diabetes Association (ADA) does not consider bromocriptine a common medication for use for type 2 diabetes; considerations include modest efficacy, potential for drug interactions, treatment cost, and frequent side effects, including nausea.
Bromocriptine is also used as monotherapy, or in combination with dantrolene, for the treatment of Neuroleptic Malignant Syndrome.
Bromocriptine interferes with proper lactation and should not be used during breast-feeding and should be avoided in the postpartum period in patients at potential cardiovascular risk.
Although bromocriptine was previously used for postpartum breast engorgement and lactation suppression, the indication for postpartum lactation suppression was voluntarily withdrawn by the manufacturer in 1994, following a prior determination by the FDA Fertility and Maternal Health Drugs Advisory Committee that safer and more conservative supportive measures were available.
Indications
- acromegaly
- amenorrhea
- hyperprolactinemia
- infertility
- mastalgia
- neuroleptic malignant syndrome
- Parkinson’s disease
- pituitary adenoma
- premenstrual syndrome (PMS)
- type 2 diabetes mellitus
For the treatment of idiopathic or postencephalitic Parkinson’s disease
Side Effects
- abdominal pain
- alopecia
- amblyopia
- anorexia
- anxiety
- asthenia
- ataxia
- blepharospasm
- blurred vision
- bradycardia
- cardiac valvulopathy
- confusion
- constipation
- depression
- diarrhea
- dizziness
- drowsiness
- dyskinesia
- dyspepsia
- dysphagia
- dyspnea
- fatigue
- GI bleeding
- hallucinations
- headache
- hypertension
- hypoglycemia
- hypotension
- impulse control symptoms
- increased urinary frequency
- infection
- influenza
- insomnia
- involuntary movements
- lethargy
- libido increase
- mania
- muscle cramps
- myocardial infarction
- nasal congestion
- nausea
- neuroleptic malignant syndrome-like symptoms
- nightmares
- orthostatic hypotension
- pallor
- paranoia
- paresthesias
- peptic ulcer
- pericardial effusion
- pericarditis
- peripheral edema
- peripheral vasoconstriction
- pleural effusion
- psychosis
- pulmonary fibrosis
- rash
- retroperitoneal fibrosis
- rhinitis
- rhinorrhea
- seizures
- sinus tachycardia
- sinusitis
- stroke
- sudden sleep onset
- syncope
- tinnitus
- urinary incontinence
- urinary retention
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- xerostomia
Monitoring Parameters
- blood glucose
- glycosylated hemoglobin A1c (HbA1c)
- neurologic function
- pregnancy testing
- serum growth hormone concentrations
- serum prolactin
Contraindications
- abrupt discontinuation
- acute myocardial infarction
- basilar/hemiplegic migraine
- breast-feeding
- cardiac disease
- children
- coadministration with other CNS depressants
- contraception requirements
- coronary artery disease
- dementia
- diabetic ketoacidosis
- driving or operating machinery
- eclampsia
- ergot alkaloid hypersensitivity
- ethanol ingestion
- fever
- geriatric
- GI bleeding
- hepatic disease
- hypertension
- hypotension
- impulse control symptoms
- infants
- infection
- lactase deficiency
- melanoma
- orthostatic hypotension
- peptic ulcer disease
- peripheral vascular disease
- preeclampsia
- pregnancy
- pregnancy testing
- psychosis
- pulmonary fibrosis
- Raynaud’s phenomenon
- renal disease
- retroperitoneal fibrosis
- rhinorrhea
- stroke
- surgery
- trauma
- type 1 diabetes mellitus
- visual impairment
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Almotriptan
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Apalutamide
- Aprepitant, Fosaprepitant
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- atypical antipsychotic
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Bexarotene
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Bosentan
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Butabarbital
- Caffeine; Ergotamine
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Cenobamate
- Ceritinib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloramphenicol
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Choline Salicylate; Magnesium Salicylate
- Ciprofloxacin
- Clarithromycin
- Clozapine
- Cobicistat
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine; Probenecid
- Conivaptan
- Conjugated Estrogens; Medroxyprogesterone
- Crizotinib
- Cyclosporine
- Dabrafenib
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Delavirdine
- Desloratadine; Pseudoephedrine
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dienogest; Estradiol valerate
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Donepezil; Memantine
- Dopamine
- Dronedarone
- Droperidol
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Eletriptan
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Ephedrine
- Epinephrine
- Ergoloid Mesylates
- Ergonovine
- Ergot alkaloids
- Ergotamine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estrogens
- Ethanol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etonogestrel
- Etravirine
- Fedratinib
- Fexofenadine; Pseudoephedrine
- Fluconazole
- Fluoxetine; Olanzapine
- Fluphenazine
- Flutamide
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Frovatriptan
- grapefruit juice
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Iloperidone
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lanreotide
- Lefamulin
- Letermovir
- Leuprolide; Norethindrone
- Levonorgestrel
- Linezolid
- Lisdexamfetamine
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Loxapine
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Magnesium Salicylate
- Mecamylamine
- Medroxyprogesterone
- Memantine
- Meperidine; Promethazine
- Mepivacaine; Levonordefrin
- Mesoridazine
- Mestranol; Norethindrone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methylene Blue
- Methylergonovine
- Methylphenidate
- Methysergide
- Metoclopramide
- Metyrapone
- Midodrine
- Mifepristone
- Mitotane
- Modafinil
- Molindone
- Nafcillin
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nicotine
- Nilotinib
- Norepinephrine
- Norethindrone
- Norgestrel
- Octreotide
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Paliperidone
- Pasireotide
- Pazopanib
- Pegvisomant
- Pergolide
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenobarbital
- Phenothiazines
- Phenoxybenzamine
- Phentermine
- Phentermine; Topiramate
- Phentolamine
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Pimozide
- Posaconazole
- Prilocaine; Epinephrine
- Primidone
- Probenecid
- Procaine
- Prochlorperazine
- Progesterone
- Progestins
- Promethazine
- Pseudoephedrine
- Pyrimethamine; Sulfadoxine
- Quetiapine
- Quinine
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Risperidone
- Ritodrine
- Ritonavir
- Rizatriptan
- Salicylates
- Salsalate
- Saquinavir
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Serotonin-Receptor Agonists
- Solriamfetol
- St. John’s Wort, Hypericum perforatum
- Sulfadiazine
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfasalazine
- Sulfisoxazole
- Sulfonamides
- Sumatriptan
- Tacrolimus
- Telithromycin
- Thiethylperazine
- Thioridazine
- Thiothixene
- Tipranavir
- tobacco
- Trandolapril; Verapamil
- Trifluoperazine
- Verapamil
- Voriconazole
- Zafirlukast
- Zileuton
- Ziprasidone
- Zolmitriptan
