Bictegravir Emtricitabine Tenofovir Alafenamide Brand Name– BIKTARVY
What is Bictegravir Emtricitabine Tenofovir Alafenamide
Bictegravir Emtricitabine Tenofovir Alafenamide is an oral 3-drug combination of a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) and 2 nucleoside analog reverse transcriptase inhibitors (NRTIs) indicated as a complete regimen for the treatment of HIV-1 infection in adults and pediatric patients weighing 25 kg or more who have no antiretroviral treatment history or to replace the current antiretroviral regimen in those who are virologically suppressed on a stable antiretroviral regimen with no history of treatment failure and no known substitutions associated with resistance to bictegravir, emtricitabine, or tenofovir alafenamide.
Bictegravir Emtricitabine Tenofovir Alafenamide contains 2 medications used for the treatment of chronic hepatitis B virus (HBV) infection (tenofovir and emtricitabine); however, it is not approved for this indication, nor is it indicated for the treatment of the patient coinfected with HBV and HIV.
All patients should be tested for HBV infection prior to initiating treatment with bictegravir; emtricitabine; tenofovir alafenamide. T
he package labeling has a Black Box Warning that acute exacerbations of hepatitis B have been reported in patients after discontinuation of tenofovir DF and emtricitabine.
- human immunodeficiency virus (HIV) infection
Side Effects
- abdominal pain
- abnormal dreams
- angioedema
- bone fractures
- bone pain
- depression
- diabetes insipidus
- diarrhea
- dizziness
- dyspepsia
- elevated hepatic enzymes
- Fanconi syndrome
- fatigue
- flatulence
- headache
- hepatic decompensation
- hepatic failure
- hepatomegaly
- hypophosphatemia
- insomnia
- interstitial nephritis
- lactic acidosis
- myalgia
- nausea
- osteopenia
- osteoporosis
- polyuria
- rash
- renal failure (unspecified)
- steatosis
- suicidal ideation
- urticaria
- vomiting
- weakness
- weight gain
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum creatinine/BUN
- serum lipid profile
- serum phosphate
- urinalysis
Contraindications
- alcoholism
- autoimmune disease
- Black patients
- bone fractures
- breast-feeding
- depression
- females
- Graves’ disease
- Guillain-Barre syndrome
- hepatic disease
- hepatitis
- hepatitis B and HIV coinfection
- hepatitis B exacerbation
- hepatitis C and HIV coinfection
- hepatomegaly
- hepatotoxicity or lactic acidosis
- Hispanic patients
- human immunodeficiency virus (HIV) infection resistance
- hypophosphatemia
- immune reconstitution syndrome
- obesity
- osteomalacia
- osteoporosis
- pregnancy
- pregnancy testing
- renal disease
- renal failure
- renal impairment
- reproductive risk
- suicidal ideation
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abacavir; Lamivudine, 3TC
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acalabrutinib
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acyclovir
- Adefovir
- Alogliptin; Metformin
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amikacin
- Aminoglycosides
- Aminosalicylate sodium, Aminosalicylic acid
- Amiodarone
- Amlodipine; Celecoxib
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphotericin B
- Amphotericin B cholesteryl sulfate complex (ABCD)
- Amphotericin B lipid complex (ABLC)
- Amphotericin B liposomal (LAmB)
- Antacids
- Apalutamide
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Bacitracin
- Barium Sulfate
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Boceprevir
- Brigatinib
- Cabozantinib
- Calcium Acetate
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Calcium Gluconate
- Canagliflozin; Metformin
- Carbamazepine
- Carboplatin
- Carvedilol
- Celecoxib
- Choline Salicylate; Magnesium Salicylate
- Cidofovir
- Cisplatin
- Clarithromycin
- Cobicistat
- Colchicine; Probenecid
- Conivaptan
- Cyclosporine
- Daclatasvir
- Dapagliflozin; Metformin
- Darolutamide
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dichlorphenamide
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Dofetilide
- Dolutegravir; Lamivudine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Echinacea
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril; Felodipine
- Ertugliflozin; Metformin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esomeprazole; Naproxen
- Estradiol; Norgestimate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Etodolac
- Famotidine; Ibuprofen
- Felodipine
- Fenoprofen
- Flibanserin
- Flurbiprofen
- food
- Foscarnet
- Fosphenytoin
- Fostamatinib
- Gadobutrol
- Gadoversetamide
- Ganciclovir
- Gentamicin
- Glecaprevir; Pibrentasvir
- Glipizide; Metformin
- Glyburide; Metformin
- grapefruit juice
- Hydrocodone; Ibuprofen
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Interferon Alfa-2b; Ribavirin
- Interferons
- Iron
- Iron Salts
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ivacaftor
- Kanamycin
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lamivudine, 3TC
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole; Naproxen
- Ledipasvir; Sofosbuvir
- Linagliptin; Metformin
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Magnesium Hydroxide
- Magnesium Salicylate
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Mifepristone
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nitisinone
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Obeticholic Acid
- Omeprazole; Amoxicillin; Rifabutin
- Orlistat
- Osimertinib
- Oxaprozin
- Oxcarbazepine
- Pamidronate
- Paromomycin
- Phenobarbital
- Phenytoin
- Pirfenidone
- Piroxicam
- Plazomicin
- Polymyxin B
- Polymyxins
- Polysaccharide-Iron Complex
- Posaconazole
- Primidone
- Probenecid
- Ranolazine
- Regorafenib
- Ribavirin
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Rivaroxaban
- Rofecoxib
- Rolapitant
- Salicylates
- Salsalate
- Sapropterin
- Simeprevir
- Sodium Ferric Gluconate Complex; ferric pyrophosphate citrate
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- St. John’s Wort, Hypericum perforatum
- Streptomycin
- Sucralfate
- Sulindac
- Tacrolimus
- Tafamidis
- Tedizolid
- Telithromycin
- Temsirolimus
- Testosterone
- Tezacaftor; Ivacaftor
- Ticagrelor
- Tipranavir
- Tobramycin
- Tolmetin
- Tolvaptan
- Trandolapril; Verapamil
- Trospium
- Valacyclovir
- Valdecoxib
- Valganciclovir
- Valproic Acid, Divalproex Sodium
- Vancomycin
- Vemurafenib
- Verapamil
- Zoledronic Acid
- Zonisamide
