Benzphetamine

Benzphetamine Brand Names- Didrex | Regimex

What is Benzphetamine

Benzphetamine is an oral, indirect-acting sympathomimetic amine that is metabolized to various amphetamines (i.e., amphetamine and methamphetamine).

Benzphetamine is used as an anorectic agent for short-term (8 to 12 weeks) adjunct treatment of exogenous obesity. Appetite-suppression activity is believed to occur by direct CNS stimulation of the satiety center in the hypothalamic and limbic regions.

Benzphetamine has a high potential for abuse and addiction.According to the American Association of Clinical Endocrinologists and American College of Endocrinology (AACE/ACE) Obesity Clinical Practice Guidelines, short-term pharmacotherapy, such as with the amphetamine anorectics, has not been shown to produce longer-term health benefits in obese and overweight patients and cannot be generally recommended and weight loss with these agents is usually not sustained.

Benzphetamine should not be used for weight management long-term.

Benzphetamine was approved by the FDA in 1960.

Indications

• obesity

For the short-term (i.e., 8 to 12 weeks) treatment of exogenous obesity

Side Effects

1. abdominal pain
2. alopecia
3. anaphylactoid reactions
4. angioedema
5. anorexia
6. anxiety
7. bradycardia
8. cardiomyopathy
9. delirium
10. diarrhea
11. dizziness
12. dysgeusia
13. dyspepsia
14. dyspnea
15. emotional lability
16. euphoria
17. fatigue
18. growth inhibition
19. hallucinations
20. headache
21. hyperhidrosis
22. hypertension
23. hyperthermia
24. impotence (erectile dysfunction)
25. insomnia
26. libido decrease
27. libido increase
28. mania
29. nausea
30. palpitations
31. paranoia
32. peripheral edema
33. photosensitivity
34. physiological dependence
35. psychological dependence
36. psychosis
37. pulmonary hypertension
38. rash
39. restlessness
40. rhabdomyolysis
41. seizures
42. serotonin syndrome
43. sinus tachycardia
44. Stevens-Johnson syndrome
45. syncope
46. tolerance
47. toxic epidermal necrolysis
48. tremor
49. urticaria
50. vomiting
51. withdrawal
52. xerostomia

Monitoring Parameters

• blood pressure
• heart rate
• weight

Contraindications

• abrupt discontinuation
• alcoholism
• angina
• anorexia nervosa
• arteriosclerosis
• bipolar disorder
• breast-feeding
• bulimia nervosa
• cardiac arrhythmias
• cardiac disease
• children
• depression
• diabetes mellitus
• driving or operating machinery
• edema
• geriatric
• glaucoma
• growth inhibition
• hypertension
• hyperthyroidism
• long QT syndrome
• mania
• MAOI therapy
• neonates
• obesity treatment
• peripheral vascular disease
• pregnancy
• psychosis
• pulmonary hypertension
• radiographic contrast administration
• Raynaud’s phenomenon
• schizophrenia
• seizure disorder
• substance abuse
• suicidal ideation
• surgery
• syncope
• thyroid disease
• tics
• Tourette’s syndrome
• valvular heart disease

Interactions

• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Diphenhydramine
• Acetaminophen; Propoxyphene
• Acetaminophen; Tramadol
• Acetazolamide
• Aclidinium; Formoterol
• Acrivastine; Pseudoephedrine
• Albiglutide
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• Albuterol; Ipratropium
• Alfentanil
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• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alkalinizing Agents
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Amantadine
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• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
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• Amoxapine
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• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
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• Chlorpheniramine; Hydrocodone
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• food
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• Green Tea
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• Hydrochlorothiazide, HCTZ; Irbesartan
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• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
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• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydroxyzine
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibritumomab Tiuxetan
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• Incretin Mimetics
• Indacaterol
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• Linezolid
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• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methazolamide
• Methenamine
• Methenamine; Sodium Acid Phosphate
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methohexital
• Methyclothiazide
• Methyldopa
• Methylene Blue
• Metolazone
• Metoprolol
• Miglitol
• Mirtazapine
• Modafinil
• Moexipril
• Molindone
• Monoamine oxidase inhibitors
• Nabilone
• Nadolol
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• Nefazodone
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• Potassium Citrate
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