Benzoyl Peroxide

Benzoyl Peroxide Brand Names

Acne Medication | Acne-10 | Acneclear | Benprox | Benzac | Benzac AC | Benzac W | Benzagel | BenzaShave | BenzEFoam | BenzEFoam Ultra | BenzePrO | Benziq | Benziq LS | BP Cleanser | BP Cleansing Lotion | BP Foaming Wash | BP Gel | BP Topical | BP Wash | BP Wash Kit | BPO | BPO Creamy Wash | BPO Foaming Cloth | Brevoxyl-4 | Brevoxyl-8 | Clearasil | Clearasil Ultra | Clearasil Vanishing | Clearplex | Clearplex X | Clearskin | Clinac BPO | Del Aqua | Delos | Desquam-E | Desquam-X | EFFACLAR | Ethexderm BPW | Inova Easy Pad | Lavoclen-4 | Lavoclen-8 | NeoBenz | NeoBenz Micro | NeoBenz Micro Cream Plus Pack | NeoBenz Micro SD | NeoBenz Micro Wash Plus Pack | OC8 | Oscion | Pacnex | Pacnex HP | Pacnex LP | Pacnex MX | PanOxyl | PanOxyl AQ | PanOxyl Aqua | Peroderm | RE Benzoyl Peroxide | Riax | SE BPO | Seba | Seba-Gel | Soluclenz Rx | Theroxide | TL BPO MX | Triaz | Zaclir | Zoderm | Zoderm Redi-Pads

What is Benzoyl Peroxide

Benzoyl peroxide is a topical acne product.

Benzoyl peroxide exhibits antibacterial activity. It also has drying actions, sebostatic effects, and causes mild skin desquamation. Benzoyl peroxide improves both inflammatory and non-inflammatory acne lesions.

Benzoyl peroxide is effective as monotherapy in mild cases of acne and is used as an adjuvant in moderate to severe cases of acne.

A study in the United Kingdom showed that an OTC 5% benzoyl peroxide topical formulation (Panoxyl Aquagel) was as effective as topical benzoyl peroxide/erythromycin combination and the oral tetracyclines minocycline and oxytetracycline for treatment of mild to moderate acne.

Topical benzoyl peroxide and benzoyl peroxide/erythromycin combinations were not associated with propionibacterial antibiotic resistance which occurs with the tetracyclines.

Benzoyl peroxide has also been used in the off-label treatment of decubitus ulcers.

Benzoyl peroxide is available as prescription and non-prescription products and is available in combination with erythromycin, hydrocortisone, and sulfur (see separate monographs for each of the combination products).

The FDA has revised labeling requirements for all non-prescription (over-the-counter) topical acne products, including benzoyl peroxide, to ensure consistency with the standardized ‘Drug Facts’ formatting.

Benzoyl peroxide is a generally recognized as safe and effective (GRASE) active ingredient in over-the-counter topical acne drug products.

Indications

  1. acne vulgaris
  2. decubitus ulcer
  3. Propionibacterium acnes
  4. varicose ulcer
  5. wound management

Side Effects

  1. anaphylactoid reactions
  2. contact dermatitis
  3. erythema
  4. pruritus
  5. rash
  6. skin irritation
  7. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • accidental exposure
  • breast-feeding
  • children
  • ocular exposure
  • pregnancy
  • skin abrasion
  • skin disease
  • sunburn
  • sunlight (UV) exposure

Interactions

  • Clindamycin; Tretinoin
  • Dapsone
  • Fluocinolone; Hydroquinone; Tretinoin
  • Halobetasol; Tazarotene
  • Hydroquinone
  • Isotretinoin
  • Mequinol; Tretinoin
  • Porfimer
  • Salicylic Acid
  • Sodium Thiosulfate; Salicylic Acid
  • Tazarotene
  • Topical Local Anesthetics
  • Tretinoin, ATRA
  • Trifarotene
  • Verteporfin
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