Bempedoic Acid Ezetimibe

Bempedoic Acid Ezetimibe Brand Name– NEXLIZET

What is Bempedoic Acid Ezetimibe

Bempedoic acid Ezetimibe is an oral antilipemic combination. Bempedoic acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor.

Ezetimibe is a potent cholesterol absorption inhibitor and selectively blocks the intestinal absorption of cholesterol and related phytosterols.

This fixed-dose combination medication is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease in adults who require additional lowering of LDL-C.

Bempedoic acid is an inactive prodrug that requires coenzyme A (CoA) activation by very long-chain acyl-CoA synthetase 1 (ACSVL1).

Since ACSVL1 is primarily located in the liver and not in adipose tissue or muscle, it is theorized to have reduced adverse effects, such as myotoxicity, due to minimal exposure to non-hepatic tissues.

Indications

  • atherosclerosis
  • heterozygous familial hypercholesterolemia

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. anemia
  4. angioedema
  5. arthralgia
  6. atrial fibrillation
  7. back pain
  8. cholecystitis
  9. cholelithiasis
  10. constipation
  11. cough
  12. depression
  13. diarrhea
  14. dizziness
  15. elevated hepatic enzymes
  16. erythema multiforme
  17. fatigue
  18. gout
  19. headache
  20. hepatitis
  21. hyperuricemia
  22. infection
  23. influenza
  24. leukopenia
  25. muscle cramps
  26. myalgia
  27. myopathy
  28. pancreatitis
  29. paresthesias
  30. pharyngitis
  31. prostatic hypertrophy
  32. rash
  33. rhabdomyolysis
  34. sinusitis
  35. tendon rupture
  36. thrombocytopenia
  37. thrombocytosis
  38. urticaria

Contraindications

  • breast-feeding
  • corticosteroid therapy
  • gout
  • hepatic disease
  • hyperuricemia
  • pregnancy
  • renal failure
  • tendon rupture

Interactions

  • Antacids
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Pravastatin
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Cholestyramine
  • Colesevelam
  • Colestipol
  • Cyclosporine
  • Eltrombopag
  • Ezetimibe; Simvastatin
  • Fenofibrate
  • Fenofibric Acid
  • Gemfibrozil
  • Niacin; Simvastatin
  • Omeprazole; Sodium Bicarbonate
  • Pravastatin
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sodium Bicarbonate
  • Warfarin