Atropine Hyoscyamine Phenobarbital Scopolamine

Atropine Hyoscyamine Phenobarbital Scopolamine Brand Names

Alkabel-SR | Antispasmodic | Barbidonna | Donnaphen | Donnatal | Donnatal Extentabs | Haponal | Hypersed | Medi-Tal | PB-HYOS | Phenohytro | Quadraplex | RE-PB Hyos | SE-DONNA PB HYOS | Servira | Spacol

What is Atropine Hyoscyamine Phenobarbital Scopolamine

Atropine Hyoscyamine Phenobarbital Scopolamine are used together in an oral preparation to treat GI-related problems such as irritable bowel syndrome.

Atropine, hyoscyamine, and scopolamine are the active components of belladonna and are sometimes referred to as belladonna alkaloids or belladonna extract.

Atropine, hyoscyamine, and scopolamine are anticholinergic agents and are used in this combination product to decrease GI motility and for their antisecretory effects.

Phenobarbital is a barbiturate agent used for its sedative actions.

Historically, this combination was one of the first drugs used in the treatment of duodenal ulcer, however, more effective agents (e.g., H2-blockers, Gastric acid-pump inhibitors) with less potential for adverse effects are available.

Conclusive evidence supporting whether anticholinergic/antispasmodic drugs aid in the healing of a duodenal ulcer, decrease the rate of ulcer recurrences, or prevent complications is not available.

Atropine Hyoscyamine Phenobarbital Scopolamine has been available since before 1938.

Indications

  • duodenal ulcer
  • enterocolitis
  • irritable bowel syndrome

For the adjunctive treatment of irritable bowel syndrome† (irritable colon, spastic colon, mucous colitis), acute enterocolitis†, or duodenal ulcer

Side Effects

  1. acneiform rash
  2. angina
  3. anxiety
  4. ataxia
  5. blurred vision
  6. bradycardia
  7. bullous rash
  8. confusion
  9. constipation
  10. cycloplegia
  11. delirium
  12. depression
  13. dizziness
  14. dyspepsia
  15. dysphagia
  16. fever
  17. flushing
  18. hallucinations
  19. headache
  20. ileus
  21. impotence (erectile dysfunction)
  22. insomnia
  23. interstitial nephritis
  24. leukocytosis
  25. libido decrease
  26. maculopapular rash
  27. megaloblastic anemia
  28. miosis
  29. mydriasis
  30. nausea
  31. nightmares
  32. nystagmus
  33. ocular hypertension
  34. osteopenia
  35. photophobia
  36. photosensitivity
  37. ptosis
  38. purpura
  39. pyrosis (heartburn)
  40. sinus tachycardia
  41. Stevens-Johnson syndrome
  42. thrombocytopenia
  43. urinary retention
  44. urticaria
  45. vomiting
  46. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • achalasia
  • acute myocardial infarction
  • ambient temperature increase
  • anticholinergic medications
  • anticoagulant therapy
  • asthma
  • autonomic neuropathy
  • barbiturate hypersensitivity
  • bladder obstruction
  • bleeding
  • breast-feeding
  • carbamazepine hypersensitivity
  • cardiac arrhythmias
  • cardiac disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • colostomy
  • contact lenses
  • coronary artery disease
  • dehydration
  • dental disease
  • depression
  • diarrhea
  • driving or operating machinery
  • esophagitis
  • ethanol ingestion
  • fever
  • gastroesophageal reflux disease (GERD)
  • geriatric
  • GI obstruction
  • glaucoma
  • heart failure
  • hepatic disease
  • hiatal hernia
  • hydantoin hypersensitivity
  • hypertension
  • hyperthyroidism
  • ileostomy
  • ileus
  • infants
  • lactase deficiency
  • mental status changes
  • mitral stenosis
  • myasthenia gravis
  • neonates
  • peptic ulcer disease
  • porphyria
  • pregnancy
  • prostatic hypertrophy
  • pseudomembranous colitis
  • pulmonary disease
  • pyloric stenosis
  • renal failure
  • renal impairment
  • respiratory depression
  • respiratory infection
  • strenuous exercise
  • substance abuse
  • suicidal ideation
  • synechia
  • tachycardia
  • thyrotoxicosis
  • toxic megacolon
  • ulcerative colitis
  • urinary retention
  • urinary tract obstruction

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  • Naldemedine
  • Naloxegol
  • Nanoparticle Albumin-Bound Paclitaxel
  • Naproxen; Pseudoephedrine
  • Nelfinavir
  • Neostigmine
  • Neratinib
  • Netupitant, Fosnetupitant; Palonosetron
  • Nevirapine
  • Niacin; Simvastatin
  • Nicardipine
  • Nifedipine
  • Nilotinib
  • Nimodipine
  • Nintedanib
  • Nisoldipine
  • Nitrofurantoin
  • Norepinephrine
  • Olanzapine
  • Olaparib
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Ondansetron
  • Oritavancin
  • Orphenadrine
  • Osilodrostat
  • Osimertinib
  • Ospemifene
  • Oxazepam
  • Oxcarbazepine
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Paclitaxel
  • Palbociclib
  • Paliperidone
  • Panobinostat
  • Papaverine
  • Paroxetine
  • Pazopanib
  • Pemoline
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Pentazocine
  • Pentazocine; Naloxone
  • Perampanel
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Pexidartinib
  • Phenelzine
  • Phenothiazines
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Physostigmine
  • Pimavanserin
  • Pioglitazone
  • Pitolisant
  • Polatuzumab Vedotin
  • Pomalidomide
  • Ponatinib
  • Potassium
  • Pralidoxime
  • Pramipexole
  • Pramlintide
  • Praziquantel
  • Prednisolone
  • Prednisone
  • Pregabalin
  • Prilocaine
  • Prilocaine; Epinephrine
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Progestins
  • Promethazine
  • Proton pump inhibitors
  • Pseudoephedrine
  • Pyridostigmine
  • Pyridoxine, Vitamin B6
  • Quazepam
  • Quetiapine
  • Quinidine
  • Quinine
  • Rabeprazole
  • Raltegravir
  • Ramelteon
  • Ranolazine
  • Rasagiline
  • Red Yeast Rice
  • Regorafenib
  • Remdesivir
  • Remifentanil
  • Repaglinide
  • Reserpine
  • Revefenacin
  • Ribociclib
  • Ribociclib; Letrozole
  • Rifampin
  • Rifapentine
  • Rilpivirine
  • Riluzole
  • Rimegepant
  • Riociguat
  • Ripretinib
  • Risperidone
  • Ritodrine
  • Ritonavir
  • Rivaroxaban
  • Rivastigmine
  • Roflumilast
  • Rolapitant
  • Romidepsin
  • Ropinirole
  • Ropivacaine
  • Rotigotine
  • Rucaparib
  • Rufinamide
  • Ruxolitinib
  • Safinamide
  • Salicylates
  • Salsalate
  • Sapropterin
  • Saquinavir
  • Scopolamine
  • Secretin
  • Sedating H1-blockers
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Selpercatinib
  • Selumetinib
  • Sertraline
  • Sildenafil
  • Simeprevir
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sincalide
  • Siponimod
  • Sirolimus
  • Skeletal Muscle Relaxants
  • Sodium Bicarbonate
  • Sodium Oxybate
  • Sofosbuvir
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Solifenacin
  • Sonidegib
  • Sorafenib
  • Spironolactone
  • Sufentanil
  • Sunitinib
  • Suvorexant
  • Tacrine
  • Tacrolimus
  • Tadalafil
  • Tamoxifen
  • Tapentadol
  • Tasimelteon
  • Tazemetostat
  • Tegaserod
  • Telaprevir
  • Telithromycin
  • Telotristat Ethyl
  • Temazepam
  • Temsirolimus
  • Teniposide
  • Tenofovir Alafenamide
  • Tenofovir Alafenamide
  • Terbinafine
  • Tetrabenazine
  • Tetracaine
  • Tezacaftor; Ivacaftor
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thioridazine
  • Thiotepa
  • Thiothixene
  • Thyroid hormones
  • Tiagabine
  • Ticagrelor
  • Tinidazole
  • Tiotropium
  • Tiotropium; Olodaterol
  • Tipranavir
  • Tizanidine
  • Tofacitinib
  • Tolcapone
  • Tolterodine
  • Tolvaptan
  • Topiramate
  • Toremifene
  • Trabectedin
  • Tramadol
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trazodone
  • Tretinoin, ATRA
  • Triamcinolone
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimethobenzamide
  • Trimetrexate
  • Triprolidine
  • Trospium
  • Tucatinib
  • Ubrogepant
  • Ulipristal
  • Umeclidinium
  • Umeclidinium; Vilanterol
  • Upadacitinib
  • Valbenazine
  • Valerian, Valeriana officinalis
  • Valproic Acid, Divalproex Sodium
  • Vandetanib
  • Vemurafenib
  • Venetoclax
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Vincristine
  • Vincristine Liposomal
  • Vorapaxar
  • Voriconazole
  • Vortioxetine
  • Voxelotor
  • Warfarin
  • Zaleplon
  • Zanubrutinib
  • Ziconotide
  • Ziprasidone
  • Zolpidem
  • Zonisamide
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