Atenolol Chlorthalidone

Atenolol Chlorthalidone Brand Name– Tenoretic

What is Atenolol Chlorthalidone

Atenolol chlorthalidone are used together in an oral preparation to treat hypertension.

These drugs have different mechanisms of action and have additive hypotensive activity.

Atenolol is a beta₁-specific, hydrophilic beta-blocker, with a long plasma half-life allowing for once-daily dosing. Due to its low-lipid solubility, atenolol is renally eliminated, minimally metabolized, and has a lower potential for inducing CNS side effects compared to lipid-soluble beta-blockers (e.g., propranolol).

Atenolol does not possess significant membrane-stabilizing activity (MSA) or intrinsic sympathomimetic properties (ISA). Chlorthalidone is a thiazide-like diuretic, with a prolonged duration of action.

Compared to other thiazides, chlorthalidone has the longest duration of action, but the diuretic effect is similar to other thiazides at maximal recommended therapeutic doses.

Tenoretic® was approved by the FDA on June 8, 1984.

Indications

• hypertension

For the treatment of hypertension in patients who do not respond to monotherapy

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. aplastic anemia
5. AV block
6. azotemia
7. blurred vision
8. bradycardia
9. bronchospasm
10. depression
11. diabetes mellitus
12. diaphoresis
13. diarrhea
14. dizziness
15. drowsiness
16. dyspnea
17. elevated hepatic enzymes
18. erythema
19. erythema multiforme
20. exfoliative dermatitis
21. fatigue
22. fever
23. glycosuria
24. gout
25. hallucinations
26. headache
27. heart failure
28. hemolytic anemia
29. hyperbilirubinemia
30. hypercalcemia
31. hypercholesterolemia
32. hyperglycemia
33. hypertension
34. hypertriglyceridemia
35. hyperuricemia
36. hypochloremia
37. hypoglycemia
38. hypokalemia
39. hypomagnesemia
40. hypotension
41. hypovolemia
42. impotence (erectile dysfunction)
43. interstitial nephritis
44. jaundice
45. lethargy
46. leukopenia
47. metabolic alkalosis
48. muscle cramps
49. nausea
50. nephrolithiasis
51. nightmares
52. orthostatic hypotension
53. palpitations
54. pancreatitis
55. pancytopenia
56. periarteritis
57. photosensitivity
58. pruritus
59. psoriaform rash
60. psoriasis
61. psychosis
62. purpura
63. rash
64. renal failure (unspecified)
65. sialadenitis
66. sinus tachycardia
67. Stevens-Johnson syndrome
68. syncope
69. teratogenesis
70. thrombocytopenia
71. toxic epidermal necrolysis
72. tremor
73. urticaria
74. vertigo
75. visual impairment
76. vomiting
77. wheezing
78. withdrawal
79. xanthopsia
80. xerophthalmia
81. xerostomia

Monitoring Parameters

• blood glucose
• blood pressure
• heart rate
• serum creatinine/BUN
• serum electrolytes
• serum uric acid

Contraindications

• abrupt discontinuation
• acute bronchospasm
• anuria
• asthma
• AV block
• beta-blocker hypersensitivity
• bradycardia
• breast-feeding
• bronchitis
• cardiogenic shock
• cerebrovascular disease
• children
• chronic obstructive pulmonary disease (COPD)
• depression
• diabetes mellitus
• driving or operating machinery
• electrolyte imbalance
• emphysema
• geriatric
• gout
• heart failure
• hepatic disease
• hypercalcemia
• hypercholesterolemia
• hyperglycemia
• hyperthyroidism
• hypertriglyceridemia
• hyperuricemia
• hypochloremia
• hypokalemia
• hypomagnesemia
• hyponatremia
• hypotension
• hypovolemia
• labor
• metabolic alkalosis
• myasthenia gravis
• obstetric delivery
• orthostatic hypotension
• pancreatitis
• peripheral vascular disease
• pheochromocytoma
• pregnancy
• psoriasis
• pulmonary disease
• pulmonary edema
• Raynaud’s phenomenon
• renal disease
• renal failure
• renal impairment
• sick sinus syndrome
• sulfonamide hypersensitivity
• sunlight (UV) exposure
• surgery
• sympathectomy
• syncope
• systemic lupus erythematosus (SLE)
• thiazide diuretic hypersensitivity
• thyroid disease
• thyrotoxicosis
• vasospastic angina
• ventricular dysfunction

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