Atazanavir Brand Name– Reyataz
What is Atazanavir
Atazanavir is a protease inhibitor for the treatment of human immunodeficiency virus (HIV) infection.
It is the first drug in its class to be given once daily.
Also, it has a unique chemical structure (azapeptide) and resistance profile compared with other available peptidomimetic protease inhibitors.
In comparison to other protease inhibitors, atazanavir does not appear to have a significant adverse effect on lipoprotein concentrations.
Like other protease inhibitors, it should be used in combination with other antiretroviral drugs.
Atazanavir is approved for use in adults and children at least 3 months of age and weighing at least 5 kg.
Atazanavir was originally approved by the FDA in June 2003.
Indications
- human immunodeficiency virus (HIV)
- human immunodeficiency virus (HIV) infection
- human immunodeficiency virus (HIV) prophylaxis
NOTE: HIV guidelines recommend atazanavir be administered concurrently with a pharmacokinetic enhancer (i.e., cobicistat or low dose ritonavir) to increase virologic potency. Atazanavir and cobicistat are available as a co-formulated combination product.
Side Effects
- abdominal pain
- alopecia
- anemia
- angioedema
- arthralgia
- AV block
- bleeding
- breast enlargement
- bundle-branch block
- cholecystitis
- cholelithiasis
- cholestasis
- cough
- Cushingoid features
- depression
- diabetes mellitus
- diabetic ketoacidosis
- diarrhea
- dizziness
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
- edema
- elevated hepatic enzymes
- erythema multiforme
- fever
- gynecomastia
- headache
- hematoma
- hyperamylasemia
- hyperbilirubinemia
- hypercholesterolemia
- hyperglycemia
- hypertriglyceridemia
- insomnia
- interstitial nephritis
- jaundice
- lipodystrophy
- maculopapular rash
- myalgia
- nausea
- nephrolithiasis
- neutropenia
- pancreatitis
- PR prolongation
- pruritus
- QT prolongation
- rash
- rhinorrhea
- Stevens-Johnson syndrome
- thrombocytopenia
- vomiting
Monitoring Parameters
- blood glucose
- CBC with differential
- CD4+ T cell count
- ECG
- hepatitis B serology
- LFTs
- plasma hepatitis C RNA
- plasma HIV RNA
- pregnancy testing
- serum bilirubin (total and direct)
- serum cholesterol
- serum creatinine/BUN
- serum lipid profile
- serum triglycerides
- urinalysis
Contraindications
- autoimmune disease
- AV block
- bleeding
- breast-feeding
- cholelithiasis
- diabetes mellitus
- diabetic ketoacidosis
- dialysis
- females
- geriatric
- Graves’ disease
- Guillain-Barre syndrome
- hemophilia
- hepatic disease
- hepatitis
- hepatitis B and HIV coinfection
- hepatitis C and HIV coinfection
- human immunodeficiency virus (HIV) infection resistance
- hypercholesterolemia
- hyperglycemia
- hyperlipidemia
- hypertriglyceridemia
- immune reconstitution syndrome
- infants
- jaundice
- lactic acidosis
- neonates
- nephrolithiasis
- obesity
- pancreatitis
- phenylketonuria
- pregnancy
- renal disease
- renal impairment
- serious rash
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Acalabrutinib
- Acarbose
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Adefovir
- Ado-Trastuzumab emtansine
- Aldesleukin, IL-2
- Alfentanil
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alogliptin
- Alogliptin; Metformin
- Alogliptin; Pioglitazone
- Alosetron
- Alpha-glucosidase Inhibitors
- Alprazolam
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Anagrelide
- Antacids
- Apalutamide
- Apixaban
- Aprepitant, Fosaprepitant
- Aripiprazole
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atovaquone
- Atovaquone; Proguanil
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Axitinib
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- Brentuximab vedotin
- Brexpiprazole
- Brigatinib
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- Cariprazine
- Ceritinib
- Cevimeline
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- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Ciclesonide
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- Digoxin
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- Elagolix
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- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
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- Enalapril; Felodipine
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- Entrectinib
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- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
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- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Ethotoin
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Famotidine
- Famotidine; Ibuprofen
- Fedratinib
- Felbamate
- Felodipine
- Fentanyl
- Fesoterodine
- Flibanserin
- Fluoxetine; Olanzapine
- Flurazepam
- Flurbiprofen
- Flutamide
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fluvastatin
- Fluvoxamine
- food
- Formoterol; Mometasone
- Fosamprenavir
- Fosphenytoin
- Fostamatinib
- Galantamine
- Gefitinib
- Gilteritinib
- Glasdegib
- Glecaprevir; Pibrentasvir
- Glipizide; Metformin
- Glyburide; Metformin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- H2-blockers
- Halofantrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibrutinib
- Ibuprofen; Oxycodone
- Idelalisib
- Ifosfamide
- Iloperidone
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- Imipramine
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- Ivacaftor
- Ivosidenib
- Ixabepilone
- Ketoconazole
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- Lamotrigine
- Lansoprazole
- Lansoprazole; Naproxen
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- Lapatinib
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- Lefamulin
- Lesinurad
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- Letermovir
- Leuprolide; Norethindrone
- Levobupivacaine
- Levomethadyl
- Levonorgestrel
- Lidocaine
- Linagliptin
- Linagliptin; Metformin
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Lorlatinib
- Losartan
- Lovastatin
- Lovastatin; Niacin
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- Lumacaftor; Ivacaftor
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- Maprotiline
- Maraviroc
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- Mefloquine
- Meloxicam
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
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- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methadone
- Methylergonovine
- Methylprednisolone
- Methysergide
- Midazolam
- Midostaurin
- Mifepristone
- Miglitol
- Mirtazapine
- Mitotane
- Modafinil
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- Nafcillin
- Naldemedine
- Naloxegol
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nebivolol; Valsartan
- Nefazodone
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
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- Olaparib
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