Aspirin Pravastatin

Aspirin Pravastatin Brand Name– Pravigard PAC

What is Aspirin Pravastatin

NOTE: This drug is discontinued in the US.

Aspirin Pravastatin combination has been approved to reduce the risk of death, non-fatal myocardial infarction, myocardial revascularization procedures and ischemic stroke in patients with cardiovascular and/or cerebrovascular disease.

Aspirin has antithrombotic and antiplatelet effects, while pravastatin is an oral HMG-CoA reductase inhibitor.

By itself, pravastatin is indicated to treat primary hypercholesterolemia, and is also used for primary or secondary prevention of myocardial infarction.

The original secondary prevention approval for pravastatin monotherapy was based on the Cholesterol and Recurrent Events (CARE) trial; 84% of patients in this trial also received aspirin.

The subsequent LIPID study also documented the secondary prevention benefit of pravastatin in patients who had a prior myocardial infarction or were hospitalized for unstable angina.

Pravigard™ PAC was FDA-approved on June 25, 2003. This FDA approval was based on combined data from five secondary prevention trials including CARE, LIPID, REGRESS, PLAC I, and PLAC II. Pravigard™ PAC includes six combinations of daily doses of buffered aspirin 81 mg or 325 mg, co-packaged with pravastatin 20 mg, 40 mg, or 80 mg tablets.

Marketing of this drug was discontinued by the manufacturer in May, 2005.

Indications

1. atherosclerosis
2. hypercholesterolemia
3. hyperlipoproteinemia
4. myocardial infarction prophylaxis
5. stroke prophylaxis

Side Effects

1. abdominal pain
2. agranulocytosis
3. alopecia
4. anaphylactoid reactions
5. angioedema
6. aplastic anemia
7. arthralgia
8. azotemia
9. bronchospasm
10. chills
11. cirrhosis
12. Co-Enzyme Q-10 deficiency
13. constipation
14. diabetes mellitus
15. diarrhea
16. dizziness
17. dyspepsia
18. dyspnea
19. elevated hepatic enzymes
20. eosinophilia
21. erythema nodosum
22. esophageal stricture
23. esophageal ulceration
24. esophagitis
25. fatigue
26. fever
27. flushing
28. gastritis
29. GI bleeding
30. GI perforation
31. headache
32. hemolytic anemia
33. hemorrhoids
34. hepatic failure
35. hepatic necrosis
36. hepatitis
37. hyperbilirubinemia
38. hyperuricemia
39. hyperventilation
40. hypoglycemia
41. hypoprothrombinemia
42. impaired cognition
43. insomnia
44. interstitial nephritis
45. intracranial bleeding
46. laryngeal edema
47. leukocytosis
48. leukopenia
49. lupus-like symptoms
50. maculopapular rash
51. malaise
52. melena
53. myalgia
54. myasthenia
55. myoglobinuria
56. myopathy
57. nausea
58. pancreatitis
59. pancytopenia
60. peptic ulcer
61. peripheral neuropathy
62. photosensitivity
63. platelet dysfunction
64. prolonged bleeding time
65. pruritus
66. purpura
67. pyrosis (heartburn)
68. rash
69. renal failure (unspecified)
70. renal papillary necrosis
71. renal tubular necrosis
72. renal tubular obstruction
73. Reye’s syndrome
74. rhabdomyolysis
75. Stevens-Johnson syndrome
76. thrombocytopenia
77. tinnitus
78. toxic epidermal necrolysis
79. urticaria
80. vasculitis
81. vomiting
82. weakness
83. wheezing

Monitoring Parameters

• creatine phosphokinase (CPK)
• LFTs
• serum cholesterol profile

Contraindications

• abrupt discontinuation
• acid/base imbalance
• acute bronchospasm
• agranulocytosis
• alcoholism
• anticoagulant therapy
• ascites
• asthma
• bone marrow suppression
• breast-feeding
• children
• cholestasis
• coagulopathy
• dehydration
• diabetes mellitus
• electrolyte imbalance
• endocrine disease
• G6PD deficiency
• geriatric
• GI bleeding
• GI disease
• gout
• head trauma
• heart failure
• hemophilia
• hepatic disease
• hepatic encephalopathy
• hepatitis
• hypertension
• hypoprothrombinemia
• hypotension
• hypovolemia
• immunosuppression
• increased intracranial pressure
• infants
• intramuscular injections
• iron-deficiency anemia
• jaundice
• labor
• metabolic acidosis
• metabolic alkalosis
• myopathy
• nasal polyps
• neutropenia
• NSAID hypersensitivity
• obstetric delivery
• organ transplant
• peptic ulcer disease
• pregnancy
• renal disease
• renal failure
• renal impairment
• respiratory acidosis
• respiratory alkalosis
• Reye’s syndrome
• rhabdomyolysis
• salicylate hypersensitivity
• seizure disorder
• sepsis
• surgery
• systemic lupus erythematosus (SLE)
• tartrazine dye hypersensitivity
• thrombocytopenia
• thrombolytic therapy
• thrombotic thrombocytopenic purpura (TTP)
• tobacco smoking
• urticaria
• viral infection
• vitamin K deficiency

Interactions

• Abciximab
• Acetaminophen
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
• Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
• Acetaminophen; Codeine
• Acetaminophen; Dextromethorphan
• Acetaminophen; Dextromethorphan; Doxylamine
• Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
• Acetaminophen; Dextromethorphan; Phenylephrine
• Acetaminophen; Dextromethorphan; Pseudoephedrine
• Acetaminophen; Dichloralphenazone; Isometheptene
• Acetaminophen; Diphenhydramine
• Acetaminophen; Guaifenesin; Phenylephrine
• Acetaminophen; Hydrocodone
• Acetaminophen; Oxycodone
• Acetaminophen; Pentazocine
• Acetaminophen; Propoxyphene
• Acetaminophen; Pseudoephedrine
• Acetaminophen; Tramadol
• Acetazolamide
• Acetohexamide
• Acidifying Agents
• Ado-Trastuzumab emtansine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Alkalinizing Agents
• Alogliptin
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Amiloride
• Amiloride; Hydrochlorothiazide, HCTZ
• Aminoglycosides
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amoxicillin
• Amoxicillin; Clarithromycin; Lansoprazole
• Amoxicillin; Clarithromycin; Omeprazole
• Amoxicillin; Clavulanic Acid
• Amphotericin B
• Amphotericin B cholesteryl sulfate complex (ABCD)
• Amphotericin B lipid complex (ABLC)
• Amphotericin B liposomal (LAmB)
• Ampicillin
• Ampicillin; Sulbactam
• Anagrelide
• Angiotensin-converting enzyme inhibitors
• Antithrombin III
• Antithymocyte Globulin
• Apixaban
• Ardeparin
• Ascorbic Acid, Vitamin C
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Aspirin, ASA; Dipyridamole
• Atazanavir
• Atazanavir; Cobicistat
• Atenolol; Chlorthalidone
• Azilsartan; Chlorthalidone
• Azithromycin
• Bacitracin
• Barbiturates
• Bempedoic Acid
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzhydrocodone; Acetaminophen
• Beta-blockers
• Betrixaban
• Bismuth Subsalicylate
• Bismuth Subsalicylate; Metronidazole; Tetracycline
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bisphosphonates
• Boceprevir
• Bortezomib
• Bromocriptine
• Bumetanide
• Buspirone
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan; Hydrochlorothiazide, HCTZ
• Capreomycin
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbenicillin
• Cefixime
• Cefotetan
• Celecoxib
• Chlorothiazide
• Chlorpropamide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Cholestyramine
• Cidofovir
• Cilostazol
• Cimetidine
• Citalopram
• Citric Acid; Potassium Citrate
• Citric Acid; Potassium Citrate; Sodium Citrate
• Citric Acid; Sodium Citrate
• Clarithromycin
• Clofarabine
• Clomipramine
• Clopidogrel
• Cobicistat
• Colchicine
• Colchicine; Probenecid
• Colestipol
• Colistimethate, Colistin, Polymyxin E
• Collagenase
• Corticosteroids
• Cyclosporine
• Dabigatran
• Daclatasvir
• Dalteparin
• Danazol
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Daptomycin
• Darunavir
• Darunavir; Cobicistat
• Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Deferasirox
• Defibrotide
• Dichlorphenamide
• Diclofenac
• Diclofenac; Misoprostol
• Dicloxacillin
• Diflunisal
• Diphenhydramine; Ibuprofen
• Diphenhydramine; Naproxen
• Dipyridamole
• Doravirine; Lamivudine; Tenofovir disoproxil fumarate
• Drotrecogin Alfa
• Edoxaban
• Efalizumab
• Efavirenz; Emtricitabine; Tenofovir
• Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
• Elexacaftor; tezacaftor; ivacaftor
• Eltrombopag
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
• Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
• Emtricitabine; Tenofovir disoproxil fumarate
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enoxaparin
• Epoprostenol
• Eprosartan; Hydrochlorothiazide, HCTZ
• Eptifibatide
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Erythromycin
• Erythromycin; Sulfisoxazole
• Escitalopram
• Esomeprazole; Naproxen
• Ethacrynic Acid
• Ethanol
• Ethotoin
• Etodolac
• Etravirine
• Everolimus
• Famotidine; Ibuprofen
• Fenofibrate
• Fenofibric Acid
• Fenoprofen
• Fibric acid derivatives
• Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
• Flavocoxid, Flavocoxid; Citrated Zinc Bisglycinate
• Fluoxetine
• Fluoxetine; Olanzapine
• Flurbiprofen
• Fluvoxamine
• Fondaparinux
• Foscarnet
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Furosemide
• Gallium Ga 68 Dotatate
• Garlic, Allium sativum
• Gemfibrozil
• Ginger, Zingiber officinale
• Ginkgo, Ginkgo biloba
• Glecaprevir; Pibrentasvir
• Glimepiride
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide
• Glipizide; Metformin
• Glyburide
• Glyburide; Metformin
• Green Tea
• Griseofulvin
• Heparin
• Hyaluronidase
• Hyaluronidase, Recombinant; Immune Globulin
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hydrocodone; Ibuprofen
• Ibritumomab Tiuxetan
• Ibrutinib
• Ibuprofen
• Ibuprofen; Oxycodone
• Ibuprofen; Pseudoephedrine
• Idelalisib
• Iloprost
• Immune Globulin IV, IVIG, IGIV
• Incretin Mimetics
• Indapamide
• Indomethacin
• Inotersen
• Insulins
• Intravenous Lipid Emulsions
• Iron Sucrose, Sucroferric Oxyhydroxide
• Isoniazid, INH; Pyrazinamide, PZA; Rifampin
• Isoniazid, INH; Rifampin
• Ketoprofen
• Ketorolac
• Lamivudine; Tenofovir Disoproxil Fumarate
• Lansoprazole; Naproxen
• Lanthanum Carbonate
• Leflunomide
• Lesinurad
• Lesinurad; Allopurinol
• Letermovir
• Linagliptin
• Linagliptin; Metformin
• Lisinopril
• Loop diuretics
• Lovastatin; Niacin
• Low Molecular Weight Heparins
• Macimorelin
• Mannitol
• Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
• Meclofenamate Sodium
• Mefenamic Acid
• Meglitinides
• Meloxicam
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methazolamide
• Methotrexate
• Methyclothiazide
• Methylsulfonylmethane, MSM
• Metoclopramide
• Metolazone
• Moexipril
• Muromonab-CD3
• Mycophenolate
• Nabumetone
• Nafcillin
• Naproxen
• Naproxen; Pseudoephedrine
• Naproxen; Sumatriptan
• Nateglinide
• Niacin, Niacinamide
• Niacin; Simvastatin
• Nitazoxanide
• Nitisinone
• Nitroglycerin
• Omacetaxine
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Amoxicillin; Rifabutin
• Omeprazole; Sodium Bicarbonate
• Orlistat
• Oxacillin
• Oxaprozin
• Paroxetine
• Penicillin G
• Penicillin G Benzathine
• Penicillin G Benzathine; Penicillin G Procaine
• Penicillin G Procaine
• Penicillin V
• Penicillins
• Pentosan
• Pentoxifylline
• Perindopril
• Perindopril; Amlodipine
• Phentermine; Topiramate
• Phenytoin
• Phosphorated Carbohydrate Solution
• Phosphorus
• Photosensitizing agents (topical)
• Pioglitazone
• Piperacillin
• Piperacillin; Tazobactam
• Piroxicam
• Pneumococcal Vaccine, Polyvalent
• Polymyxins
• Potassium Bicarbonate
• Potassium Chloride
• Potassium Citrate
• Potassium Phosphate
• Potassium Phosphate; Sodium Phosphate
• Pramlintide
• Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
• Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
• Prasugrel
• Probenecid
• Psyllium
• Quinapril
• Raltegravir
• Ramipril
• Red Yeast Rice
• Repaglinide
• Rifabutin
• Rifampin
• Rifapentine
• Rituximab; Hyaluronidase
• Rivaroxaban
• Rosiglitazone
• Salicylic Acid
• Saxagliptin
• Selective serotonin reuptake inhibitors
• Serotonin norepinephrine reuptake inhibitors
• Sertraline
• Sibutramine
• Simeprevir
• Simvastatin; Sitagliptin
• Sirolimus
• Sitagliptin
• Sodium Bicarbonate
• Sodium Hyaluronate, Hyaluronic Acid
• Sodium Lactate
• Sodium Thiosulfate; Salicylic Acid
• Sofosbuvir; Velpatasvir; Voxilaprevir
• Spironolactone
• Sulfinpyrazone
• Sulfonamides
• Sulfonylureas
• Sulindac
• Tacrolimus
• Telavancin
• Telbivudine
• Telithromycin
• Tenofovir Alafenamide
• Tenofovir, PMPA
• Teriflunomide
• Thiazide diuretics
• Thiazolidinediones
• Thrombin Inhibitors
• Thrombolytic Agents
• Ticagrelor
• Ticarcillin
• Ticarcillin; Clavulanic Acid
• Ticlopidine
• Tinzaparin
• Tipranavir
• Tirofiban
• Tolazamide
• Tolbutamide
• Tolmetin
• Tolvaptan
• Topiramate
• Torsemide
• Trandolapril
• Trandolapril; Verapamil
• Trastuzumab; Hyaluronidase
• Trazodone
• Treprostinil
• Triamterene
• Tromethamine
• Valproic Acid, Divalproex Sodium
• Vancomycin
• Varicella-Zoster Virus Vaccine, Live
• Verapamil
• Verteporfin
• Vilazodone
• Vorapaxar
• Vortioxetine
• Warfarin
• Zafirlukast