Aspirin Omeprazole

Aspirin Omeprazole Brand Name– Yosprala

What is Aspirin Omeprazole

Aspirin omeprazole is a combination of aspirin, an antiplatelet agent, and omeprazole, a proton pump inhibitor, for patients who require aspirin for secondary prevention of cardiovascular and cerebrovascular events and who are at risk of developing aspirin-associated gastric ulcers.

Although the combination product is approved for use in patients at risk for developing aspirin-associated gastric ulcers, the combination product has not been shown to reduce the risk of gastrointestinal bleeding due to aspirin.

Aspirin omeprazole is not for use as the initial dose of aspirin therapy during onset of acute coronary syndrome, acute myocardial infarction, or before percutaneous coronary intervention.

Aspirin omeprazole was FDA-approved in September 2016.

Indications

  • myocardial infarction prophylaxis
  • reduction of cardiovascular mortality
  • stroke prophylaxis

For the reduction of cardiovascular mortality and prevention of secondary cardiovascular and cerebrovascular events (e.g., myocardial infarction prophylaxis, stroke prophylaxis) in patients at risk for aspirin associated gastric ulcers and also have a history of stroke, TIA, myocardial infarction, angina (including unstable angina), or are post cardiac surgery (CABG, PTCA)

Side Effects

  1. abdominal pain
  2. abnormal dreams
  3. agitation
  4. agranulocytosis
  5. alopecia
  6. anaphylactic shock
  7. anaphylactoid reactions
  8. anemia
  9. angina
  10. angioedema
  11. anorexia
  12. anxiety
  13. arthralgia
  14. blurred vision
  15. bone fractures
  16. bradycardia
  17. bronchospasm
  18. candidiasis
  19. cerebral edema
  20. chest pain (unspecified)
  21. cholestasis
  22. coagulopathy
  23. colitis
  24. coma
  25. confusion
  26. dehydration
  27. depression
  28. diarrhea
  29. diplopia
  30. disseminated intravascular coagulation (DIC)
  31. dizziness
  32. drowsiness
  33. dysgeusia
  34. dyspepsia
  35. elevated hepatic enzymes
  36. epistaxis
  37. erythema multiforme
  38. fatigue
  39. fever
  40. gastric polyps
  41. gastritis
  42. GI bleeding
  43. GI obstruction
  44. GI perforation
  45. glycosuria
  46. gynecomastia
  47. hallucinations
  48. headache
  49. hearing loss
  50. hematuria
  51. hemolytic anemia
  52. hepatic encephalopathy
  53. hepatic failure
  54. hepatic necrosis
  55. hepatitis
  56. hostility
  57. hyperglycemia
  58. hyperhidrosis
  59. hypertension
  60. hypocalcemia
  61. hypoglycemia
  62. hypokalemia
  63. hypomagnesemia
  64. hyponatremia
  65. hypotension
  66. hypothermia
  67. increased urinary frequency
  68. insomnia
  69. interstitial nephritis
  70. intracranial bleeding
  71. jaundice
  72. laryngeal edema
  73. lethargy
  74. leukocytosis
  75. leukopenia
  76. lupus-like symptoms
  77. malaise
  78. metabolic acidosis
  79. muscle cramps
  80. musculoskeletal pain
  81. myalgia
  82. myasthenia
  83. nausea
  84. neutropenia
  85. ocular irritation
  86. optic atrophy
  87. optic neuritis
  88. palpitations
  89. pancreatitis
  90. pancytopenia
  91. paresthesias
  92. peptic ulcer
  93. peripheral edema
  94. petechiae
  95. photosensitivity
  96. prolonged bleeding time
  97. proteinuria
  98. pruritus
  99. pulmonary edema
  100. purpura
  101. pyuria
  102. rash
  103. renal failure (unspecified)
  104. renal papillary necrosis
  105. rhabdomyolysis
  106. seizures
  107. sinus tachycardia
  108. Stevens-Johnson syndrome
  109. stomatitis
  110. stool discoloration
  111. tachypnea
  112. testicular pain
  113. throat irritation
  114. thrombocytopenia
  115. tinnitus
  116. toxic epidermal necrolysis
  117. tremor
  118. urticaria
  119. vertigo
  120. vitamin B12 deficiency
  121. vomiting
  122. weight gain
  123. xerophthalmia
  124. xerosis
  125. xerostomia

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN
  • serum magnesium
  • stool guaiac

Contraindications

  • abrupt discontinuation
  • alcoholism
  • breast-feeding
  • children
  • coagulopathy
  • diarrhea
  • gastric cancer
  • gastritis
  • geriatric
  • GI bleeding
  • hemophilia
  • hepatic disease
  • hypomagnesemia
  • labor
  • NSAID hypersensitivity
  • obstetric delivery
  • osteoporosis
  • pregnancy
  • renal failure
  • salicylate hypersensitivity
  • systemic lupus erythematosus (SLE)
  • viral infection
  • vitamin B12 deficiency
  • vitamin K deficiency

Interactions

  • Abciximab
  • Acalabrutinib
  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acetazolamide
  • Acetohexamide
  • Acidifying Agents
  • Ado-Trastuzumab emtansine
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  • Amobarbital
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