Aspirin Omeprazole Brand Name– Yosprala
What is Aspirin Omeprazole
Aspirin omeprazole is a combination of aspirin, an antiplatelet agent, and omeprazole, a proton pump inhibitor, for patients who require aspirin for secondary prevention of cardiovascular and cerebrovascular events and who are at risk of developing aspirin-associated gastric ulcers.
Although the combination product is approved for use in patients at risk for developing aspirin-associated gastric ulcers, the combination product has not been shown to reduce the risk of gastrointestinal bleeding due to aspirin.
Aspirin omeprazole is not for use as the initial dose of aspirin therapy during onset of acute coronary syndrome, acute myocardial infarction, or before percutaneous coronary intervention.
Aspirin omeprazole was FDA-approved in September 2016.
Indications
- myocardial infarction prophylaxis
- reduction of cardiovascular mortality
- stroke prophylaxis
For the reduction of cardiovascular mortality and prevention of secondary cardiovascular and cerebrovascular events (e.g., myocardial infarction prophylaxis, stroke prophylaxis) in patients at risk for aspirin associated gastric ulcers and also have a history of stroke, TIA, myocardial infarction, angina (including unstable angina), or are post cardiac surgery (CABG, PTCA)
Side Effects
- abdominal pain
- abnormal dreams
- agitation
- agranulocytosis
- alopecia
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angina
- angioedema
- anorexia
- anxiety
- arthralgia
- blurred vision
- bone fractures
- bradycardia
- bronchospasm
- candidiasis
- cerebral edema
- chest pain (unspecified)
- cholestasis
- coagulopathy
- colitis
- coma
- confusion
- dehydration
- depression
- diarrhea
- diplopia
- disseminated intravascular coagulation (DIC)
- dizziness
- drowsiness
- dysgeusia
- dyspepsia
- elevated hepatic enzymes
- epistaxis
- erythema multiforme
- fatigue
- fever
- gastric polyps
- gastritis
- GI bleeding
- GI obstruction
- GI perforation
- glycosuria
- gynecomastia
- hallucinations
- headache
- hearing loss
- hematuria
- hemolytic anemia
- hepatic encephalopathy
- hepatic failure
- hepatic necrosis
- hepatitis
- hostility
- hyperglycemia
- hyperhidrosis
- hypertension
- hypocalcemia
- hypoglycemia
- hypokalemia
- hypomagnesemia
- hyponatremia
- hypotension
- hypothermia
- increased urinary frequency
- insomnia
- interstitial nephritis
- intracranial bleeding
- jaundice
- laryngeal edema
- lethargy
- leukocytosis
- leukopenia
- lupus-like symptoms
- malaise
- metabolic acidosis
- muscle cramps
- musculoskeletal pain
- myalgia
- myasthenia
- nausea
- neutropenia
- ocular irritation
- optic atrophy
- optic neuritis
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- peptic ulcer
- peripheral edema
- petechiae
- photosensitivity
- prolonged bleeding time
- proteinuria
- pruritus
- pulmonary edema
- purpura
- pyuria
- rash
- renal failure (unspecified)
- renal papillary necrosis
- rhabdomyolysis
- seizures
- sinus tachycardia
- Stevens-Johnson syndrome
- stomatitis
- stool discoloration
- tachypnea
- testicular pain
- throat irritation
- thrombocytopenia
- tinnitus
- toxic epidermal necrolysis
- tremor
- urticaria
- vertigo
- vitamin B12 deficiency
- vomiting
- weight gain
- xerophthalmia
- xerosis
- xerostomia
Monitoring Parameters
- LFTs
- serum creatinine/BUN
- serum magnesium
- stool guaiac
Contraindications
- abrupt discontinuation
- alcoholism
- breast-feeding
- children
- coagulopathy
- diarrhea
- gastric cancer
- gastritis
- geriatric
- GI bleeding
- hemophilia
- hepatic disease
- hypomagnesemia
- labor
- NSAID hypersensitivity
- obstetric delivery
- osteoporosis
- pregnancy
- renal failure
- salicylate hypersensitivity
- systemic lupus erythematosus (SLE)
- viral infection
- vitamin B12 deficiency
- vitamin K deficiency
Interactions
- Abciximab
- Acalabrutinib
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acetazolamide
- Acetohexamide
- Acidifying Agents
- Ado-Trastuzumab emtansine
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