Arginine

Arginine Brand Name– R-Gene

What is Arginine

Arginine hydrochloride is a synthetic derivative of the essential amino acid L-arginine.

Arginine hydrochloride may be used as an aid to the detection of growth hormone deficiency in conditions such as panhypopituitarism, pituitary dwarfism, chromophobe adenoma, postsurgical craniopharyngioma, hypophysectomy, pituitary trauma, and in problems with growth and stature.

The drug has also been used in the evaluation of pituitary function in gigantism and acromegaly

Further, arginine injection is used to treat high ammonia concentrations in patients with urea cycle disorders.

Arginine tablets, which are dietary supplements, have been used to improve exercise capacity in patients with stable angina pectoris.

Arginine injection was originally approved by the FDA in February 1973.

Indications

  • angina
  • growth hormone deficiency diagnosis
  • hyperammonemia
  • interstitial cystitis

For growth hormone deficiency diagnosis (i.e., evaluation of pituitary growth hormone reserve)

Side Effects

  1. anaphylactoid reactions
  2. flushing
  3. headache
  4. hematuria
  5. hyperventilation
  6. hypotension
  7. injection site reaction
  8. lethargy
  9. maculopapular rash
  10. metabolic acidosis
  11. nausea
  12. paresthesias
  13. skin necrosis
  14. thrombocytopenia
  15. vomiting

Monitoring Parameters

  • serum growth hormone concentrations

Contraindications

  • breast-feeding
  • children
  • electrolyte imbalance
  • hepatic disease
  • infants
  • neonates
  • pregnancy
  • renal impairment

Interactions

  • Ethanol

Ethanol: (Moderate) Excessive ethanol (e.g., alcoholism) may result in increased urinary excretion of magnesium. Avoid high intakes of ethanol while taking magnesium salts. 

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