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Aprepitant Fosaprepitant Brand Names- CINVANTI / Emend
What is Aprepitant Fosaprepitant
Aprepitant fosaprepitant an antiemetic, is a highly selective substance P neurokinin 1 (NK1) receptor antagonist.
Aprepitant is available in oral and intravenous formulations; fosaprepitant, the prodrug of aprepitant, is only available as an intravenous formulation.
Aprepitant (oral and IV) and injectable fosaprepitant are approved for use in combination with standard antiemetic regimens (5HT3 antagonist plus a corticosteroid) to prevent acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic regimens and delayed CINV associated with moderately emetogenic regimens.
While previously FDA-approved for post-operative nausea and vomiting, the manufacturers removed this indication from the labels in September 2019.
Indications
- chemotherapy-induced nausea/vomiting prophylaxis
For chemotherapy-induced nausea/vomiting prophylaxis (CINV prophylaxis)
for acute and delayed chemotherapy-induced nausea/vomiting (CINV) prophylaxis associated with highly-emetogenic chemotherapy\
Side Effects
- abdominal pain
- abnormal dreams
- acne vulgaris
- agitation
- alopecia
- anaphylactic shock
- anaphylactoid reactions
- anemia
- angioedema
- anxiety
- asthenia
- bradycardia
- candidiasis
- chills
- colitis
- conjunctivitis
- constipation
- cough
- dehydration
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- dyspnea
- dysuria
- edema
- elevated hepatic enzymes
- eructation
- erythema
- euphoria
- fatigue
- flatulence
- flushing
- gastritis
- gastroesophageal reflux
- headache
- hematuria
- hiccups
- hot flashes
- hyperglycemia
- hyperhidrosis
- hypokalemia
- hyponatremia
- hypotension
- ileus
- infection
- infusion-related reactions
- injection site reaction
- lethargy
- leukopenia
- malaise
- muscle cramps
- musculoskeletal pain
- myalgia
- nausea
- neurotoxicity
- neutropenia
- palpitations
- peripheral edema
- peripheral neuropathy
- pharyngitis
- phlebitis
- photosensitivity
- polydipsia
- polyuria
- proteinuria
- pruritus
- rash
- skin irritation
- skin necrosis
- sneezing
- Stevens-Johnson syndrome
- stomatitis
- syncope
- throat irritation
- thrombocytopenia
- tinnitus
- toxic epidermal necrolysis
- urticaria
- vasculitis
- vomiting
- weight gain
- weight loss
- wheezing
- xerostomia
Monitoring Parameters
- heart rate
- LFTs
Contraindications
- anticoagulant therapy
- breast-feeding
- contraception requirements
- contraceptive devices
- geriatric
- hepatic disease
- hypotension
- infusion-related reactions
- pregnancy
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Abemaciclib
- Acalabrutinib
- Acetaminophen
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Alfentanil
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alprazolam
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Apalutamide
- Aripiprazole
- Armodafinil
- Artemether; Lumefantrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Azilsartan
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- Cariprazine
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- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
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- Docetaxel
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- Donepezil
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- Duvelisib
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- Eletriptan
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- Eliglustat
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- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
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- Enalapril; Felodipine
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- Entrectinib
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- Esomeprazole; Naproxen
- Estazolam
- Esterified Estrogens
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- Estradiol; Norethindrone
- Estradiol; Norgestimate
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- Estropipate
- Eszopiclone
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
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- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
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- Etravirine
- Everolimus
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- food
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- Fosphenytoin
- Glimepiride
- Glimepiride; Pioglitazone
- Glimepiride; Rosiglitazone
- Glipizide
- Glipizide; Metformin
- Glyburide
- Glyburide; Metformin
- Granisetron
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guanfacine
- Halofantrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Ibrutinib
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
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- Iloperidone
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- Imipramine
- Indinavir
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- Ipecac
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- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
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- Isradipine
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivermectin
- Ivosidenib
- Ixabepilone
- Ketoconazole
- Lansoprazole
- Lansoprazole; Naproxen
- Lefamulin
- Lesinurad
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- Letermovir
- Leuprolide; Norethindrone
- Levomethadyl
- Levomilnacipran
- Levonorgestrel
- Lidocaine
- Linagliptin
- Linagliptin; Metformin
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Losartan
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Macitentan
- Maprotiline
- Maraviroc
- Medroxyprogesterone
- Mefloquine
- Meloxicam
- Mephobarbital
- Mestranol; Norethindrone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Methadone
- Methohexital
- Methylergonovine
- Methylprednisolone
- Methysergide
- Midazolam
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Naldemedine
- Naloxegol
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Neratinib
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Niacin; Simvastatin
- Nicardipine
- Nifedipine
- Nilotinib
- Nimodipine
- Nisoldipine
- Norethindrone
- Norgestrel
- Nortriptyline
- Octreotide
- Olaparib
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ondansetron
- Oritavancin
- Oxybutynin
- Oxycodone
- Paclitaxel
- Palonosetron
- Panobinostat
- Paricalcitol
- Pazopanib
- Pentobarbital
- Perampanel
- Pergolide
- Perindopril; Amlodipine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phentermine; Topiramate
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- Pitavastatin
- Posaconazole
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- Quetiapine
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- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
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- Rilpivirine
- Rimegepant
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- Roflumilast
- Rolapitant
- Romidepsin
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- Rosiglitazone
- Rosuvastatin
- Ruxolitinib
- Sacubitril; Valsartan
- Saquinavir
- Saxagliptin
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
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- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Siponimod
- Sirolimus
- Sofosbuvir; Velpatasvir
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- Solifenacin
- Sonidegib
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Suvorexant
- Tacrolimus
- Tadalafil
- Tamsulosin
- Tasimelteon
- Tazemetostat
- Telaprevir
- Telithromycin
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- Teniposide
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- Testosterone
- Tezacaftor; Ivacaftor
- Theophylline, Aminophylline
- Tiagabine
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- Tinidazole
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- Tofacitinib
- Tolterodine
- Tolvaptan
- Topiramate
- Torsemide
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- Valsartan
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- Warfarin
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- Zanubrutinib
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- Ziprasidone
- Zolmitriptan
- Zolpidem
- Zonisamide
