Amphetamine and Dextroamphetamine

Amphetamine and Dextroamphetamine Brand Names

Adderall | Adderall XR | Mydayis

What is Amphetamine and Dextroamphetamine

Amphetamine and dextroamphetamine mixed salts are used in combination as an oral preparation to treat attention-deficit hyperactivity disorder (ADHD) or narcolepsy.

Stimulants are considered first-line agents in the treatment of ADHD.

Amphetamine- and methylphenidate-containing products are considered equally effective in the treatment of ADHD; patients who do not respond to one may respond to the other.

The most common adverse reactions associated with amphetamine use include anorexia, abdominal pain, irritability, restlessness, insomnia, emotional lability, and tachycardia.

Stimulants can induce or exacerbate psychiatric symptoms and should be used with caution in patients with a history of mania, psychosis, or substance abuse.

Due to the possibility of new or worsening adverse psychiatric events (e.g., psychosis, aggression), close monitoring is recommended in patients with pre-existing psychosis or bipolar disorder.

Stimulants have also been associated with sudden death in patients with structural cardiac abnormalities; patients with structural heart defects, cardiomyopathy, or heart-rhythm disturbances may be at risk for adverse cardiac events.

The American Heart Association recommends careful screening of all children and adolescents prior to initiating pharmacologic therapy for attention-deficit hyperactivity disorder (ADHD), including a detailed patient and family history and physical examination.

Indications

• attention-deficit hyperactivity disorder (ADHD)
• narcolepsy

Side Effects

1. abdominal pain
2. agitation
3. alopecia
4. anaphylactoid reactions
5. angioedema
6. anorexia
7. anxiety
8. arrhythmia exacerbation
9. asthenia
10. blurred vision
11. bradycardia
12. cardiomyopathy
13. chest pain (unspecified)
14. coma
15. confusion
16. constipation
17. delirium
18. dental caries
19. depression
20. diarrhea
21. dizziness
22. drowsiness
23. dysgeusia
24. dyskinesia
25. dysmenorrhea
26. dyspepsia
27. dysphemia
28. dysphoria
29. dyspnea
30. emotional lability
31. euphoria
32. fever
33. formication
34. growth inhibition
35. hallucinations
36. headache
37. hostility
38. hyperhidrosis
39. hyperreflexia
40. hypertension
41. hyperthermia
42. hypotension
43. impotence (erectile dysfunction)
44. infection
45. insomnia
46. irritability
47. libido decrease
48. libido increase
49. mania
50. mydriasis
51. myocardial infarction
52. nausea
53. ocular hypertension
54. palpitations
55. paranoia
56. paresthesias
57. peripheral vasoconstriction
58. photosensitivity
59. physiological dependence
60. priapism
61. psychological dependence
62. psychosis
63. rash
64. renal failure (unspecified)
65. restlessness
66. rhabdomyolysis
67. seizures
68. serotonin syndrome
69. sinus tachycardia
70. skin ulcer
71. Stevens-Johnson syndrome
72. stroke
73. suicidal ideation
74. supranormalization
75. syncope
76. tachypnea
77. teeth grinding (bruxism)
78. tolerance
79. Tourette’s syndrome
80. toxic epidermal necrolysis
81. tremor
82. urticaria
83. visual impairment
84. vomiting
85. weight loss
86. withdrawal
87. xerostomia

Monitoring Parameters

• blood pressure
• growth rate
• heart rate
• weight

Contraindications

• abrupt discontinuation
• acute myocardial infarction
• alcoholism
• anorexia nervosa
• aortic stenosis
• arteriosclerosis
• bipolar disorder
• breast-feeding
• bulimia nervosa
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• cerebrovascular disease
• children
• congenital heart disease
• coronary artery disease
• depression
• driving or operating machinery
• geriatric
• glaucoma
• growth inhibition
• heart failure
• hepatic disease
• hypercortisolism
• hypertension
• hyperthyroidism
• infants
• mania
• MAOI therapy
• myocardial infarction
• neonates
• obesity treatment
• peripheral vascular disease
• pregnancy
• prosthetic heart valves
• psychosis
• radiographic contrast administration
• Raynaud’s phenomenon
• renal failure
• renal impairment
• schizophrenia
• seizure disorder
• seizures
• stroke
• substance abuse
• suicidal ideation
• surgery
• tachycardia
• thyrotoxicosis
• tics
• Tourette’s syndrome
• valvular heart disease
• ventricular arrhythmias
• ventricular dysfunction
• visual disturbance

Interactions

• Acarbose
• Acebutolol
• Acetaminophen; Aspirin, ASA; Caffeine
• Acetaminophen; Butalbital; Caffeine
• Acetaminophen; Butalbital; Caffeine; Codeine
• Acetaminophen; Caffeine
• Acetaminophen; Caffeine; Dihydrocodeine
• Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
• Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
• Acetaminophen; Tramadol
• Acetazolamide
• Aclidinium; Formoterol
• Albiglutide
• Albuterol
• Albuterol; Ipratropium
• Alfentanil
• Aliskiren; Amlodipine
• Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
• Aliskiren; Hydrochlorothiazide, HCTZ
• Aliskiren; Valsartan
• Alkalinizing Agents
• Alogliptin; Metformin
• Alogliptin; Pioglitazone
• Alpha-glucosidase Inhibitors
• Aluminum Hydroxide
• Aluminum Hydroxide; Magnesium Carbonate
• Aluminum Hydroxide; Magnesium Hydroxide
• Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
• Aluminum Hydroxide; Magnesium Trisilicate
• Amantadine
• Ambrisentan
• Amifampridine
• Amiloride; Hydrochlorothiazide, HCTZ
• Amlodipine
• Amlodipine; Atorvastatin
• Amlodipine; Benazepril
• Amlodipine; Celecoxib
• Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
• Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
• Amlodipine; Olmesartan
• Amlodipine; Telmisartan
• Amlodipine; Valsartan
• Ammonium Chloride
• Amoxapine
• Angiotensin II receptor antagonists
• Angiotensin-converting enzyme inhibitors
• Antacids
• Arformoterol
• Armodafinil
• Ascorbic Acid, Vitamin C
• Aspirin, ASA; Butalbital; Caffeine
• Aspirin, ASA; Butalbital; Caffeine; Codeine
• Aspirin, ASA; Caffeine; Dihydrocodeine
• Aspirin, ASA; Caffeine; Orphenadrine
• Aspirin, ASA; Citric Acid; Sodium Bicarbonate
• Atenolol
• Atenolol; Chlorthalidone
• Atomoxetine
• Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Atropine; Hyoscyamine; Phenobarbital; Scopolamine
• Azilsartan
• Azilsartan; Chlorthalidone
• Belladonna Alkaloids; Ergotamine; Phenobarbital
• Benazepril
• Benazepril; Hydrochlorothiazide, HCTZ
• Bendroflumethiazide; Nadolol
• Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
• Beta-blockers
• Betaxolol
• Bethanechol
• Bisoprolol
• Bisoprolol; Hydrochlorothiazide, HCTZ
• Bosentan
• Bretylium
• Brimonidine; Timolol
• Bromocriptine
• Budesonide; Formoterol
• Bupropion
• Bupropion; Naltrexone
• Buspirone
• Caffeine
• Caffeine; Ergotamine
• Calcium Carbonate
• Calcium Carbonate; Magnesium Hydroxide
• Calcium Carbonate; Risedronate
• Calcium Carbonate; Simethicone
• Calcium-channel blockers
• Canagliflozin
• Canagliflozin; Metformin
• Candesartan
• Candesartan; Hydrochlorothiazide, HCTZ
• Captopril
• Captopril; Hydrochlorothiazide, HCTZ
• Carbamazepine
• Carbidopa; Levodopa
• Carbidopa; Levodopa; Entacapone
• Cardiac glycosides
• Carteolol
• Carvedilol
• Chlorothiazide
• Chlorthalidone
• Chlorthalidone; Clonidine
• Cimetidine
• Cinacalcet
• Citalopram
• Citric Acid; Potassium Citrate
• Citric Acid; Potassium Citrate; Sodium Citrate
• Citric Acid; Sodium Citrate
• Clevidipine
• Clobazam
• Clonazepam
• Clonidine
• Cocaine
• Colchicine
• Colchicine; Probenecid
• Dacomitinib
• Dapagliflozin
• Dapagliflozin; Metformin
• Dapagliflozin; Saxagliptin
• Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
• Delavirdine
• Desvenlafaxine
• Dextromethorphan; Quinidine
• Diazepam
• Digitoxin
• Digoxin
• Dihydroergotamine
• Diltiazem
• Dipeptidyl Peptidase-4 Inhibitors
• Dorzolamide; Timolol
• Doxazosin
• Dronabinol
• Dulaglutide
• Duloxetine
• Dyphylline
• Dyphylline; Guaifenesin
• Empagliflozin
• Empagliflozin; Linagliptin
• Empagliflozin; Linagliptin; Metformin
• Empagliflozin; Metformin
• Enalapril, Enalaprilat
• Enalapril; Felodipine
• Enalapril; Hydrochlorothiazide, HCTZ
• Enflurane
• Eplerenone
• Epoprostenol
• Eprosartan
• Eprosartan; Hydrochlorothiazide, HCTZ
• Ergoloid Mesylates
• Ergonovine
• Ergot alkaloids
• Ergotamine
• Ertugliflozin
• Ertugliflozin; Metformin
• Ertugliflozin; Sitagliptin
• Escitalopram
• Esketamine
• Eslicarbazepine
• Esmolol
• Ethanol
• Ethotoin
• Etomidate
• Exenatide
• Ezogabine
• Famotidine
• Famotidine; Ibuprofen
• Felbamate
• Felodipine
• Fentanyl
• Fluoxetine
• Fluoxetine; Olanzapine
• Fluticasone; Salmeterol
• Fluticasone; Umeclidinium; Vilanterol
• Fluticasone; Vilanterol
• Fluvoxamine
• food
• Formoterol
• Formoterol; Mometasone
• Fosinopril
• Fosinopril; Hydrochlorothiazide, HCTZ
• Fosphenytoin
• Gabapentin
• Glimepiride; Pioglitazone
• Glimepiride; Rosiglitazone
• Glipizide; Metformin
• Glyburide; Metformin
• Glycopyrrolate; Formoterol
• Green Tea
• Guanabenz
• Guanfacine
• H2-blockers
• Halothane
• Hydantoins
• Hydralazine; Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ
• Hydrochlorothiazide, HCTZ; Irbesartan
• Hydrochlorothiazide, HCTZ; Lisinopril
• Hydrochlorothiazide, HCTZ; Losartan
• Hydrochlorothiazide, HCTZ; Methyldopa
• Hydrochlorothiazide, HCTZ; Metoprolol
• Hydrochlorothiazide, HCTZ; Moexipril
• Hydrochlorothiazide, HCTZ; Olmesartan
• Hydrochlorothiazide, HCTZ; Propranolol
• Hydrochlorothiazide, HCTZ; Quinapril
• Hydrochlorothiazide, HCTZ; Spironolactone
• Hydrochlorothiazide, HCTZ; Telmisartan
• Hydrochlorothiazide, HCTZ; Triamterene
• Hydrochlorothiazide, HCTZ; Valsartan
• Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
• Ibritumomab Tiuxetan
• Iloprost
• Incretin Mimetics
• Indacaterol
• Indacaterol; Glycopyrrolate
• Indapamide
• Insulin Degludec; Liraglutide
• Insulin Glargine; Lixisenatide
• Insulins
• Iobenguane I 131
• Irbesartan
• Isocarboxazid
• Isoflurane
• Isradipine
• Ketamine
• Labetalol
• Lacosamide
• Lamotrigine
• Lasmiditan
• Levalbuterol
• Levetiracetam
• Levobetaxolol
• Levobunolol
• Levodopa
• Levomilnacipran
• Levothyroxine
• Levothyroxine; Liothyronine (Porcine)
• Levothyroxine; Liothyronine (Synthetic)
• Linagliptin; Metformin
• Linezolid
• Liothyronine
• Liraglutide
• Lisinopril
• Lithium
• Lixisenatide
• Loop diuretics
• Lopinavir; Ritonavir
• Lorazepam
• Lorcaserin
• Losartan
• Loxapine
• Lurasidone
• Macitentan
• Magnesium Hydroxide
• Maprotiline
• Mecamylamine
• Meglitinides
• Meperidine
• Meperidine; Promethazine
• Mephobarbital
• Metaproterenol
• Metformin
• Metformin; Pioglitazone
• Metformin; Repaglinide
• Metformin; Rosiglitazone
• Metformin; Saxagliptin
• Metformin; Sitagliptin
• Methazolamide
• Methenamine
• Methenamine; Sodium Acid Phosphate
• Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
• Methohexital
• Methyclothiazide
• Methyldopa
• Methylene Blue
• Methylergonovine
• Methysergide
• Metolazone
• Metoprolol
• Miglitol
• Milnacipran
• Mirtazapine
• Modafinil
• Moexipril
• Molindone
• Monoamine oxidase inhibitors
• Nabilone
• Nadolol
• Nebivolol
• Nebivolol; Valsartan
• Nefazodone
• Nicardipine
• Nicotine
• Nifedipine
• Nimodipine
• Nisoldipine
• Nitrates
• Nizatidine
• Non-Ionic Contrast Media
• Olmesartan
• Ombitasvir; Paritaprevir; Ritonavir
• Omeprazole; Sodium Bicarbonate
• Ozanimod
• Paroxetine
• Penbutolol
• Pentobarbital
• Perampanel
• Pergolide
• Perindopril
• Perindopril; Amlodipine
• Phenelzine
• Phenobarbital
• Phenoxybenzamine
• Phentermine
• Phentermine; Topiramate
• Phentolamine
• Phenytoin
• Pindolol
• Pioglitazone
• Pirbuterol
• Potassium Bicarbonate
• Potassium Citrate
• Potassium-sparing diuretics
• Pramlintide
• Prazosin
• Pregabalin
• Primidone
• Procarbazine
• Propofol
• Propranolol
• Proton pump inhibitors
• Quinapril
• Quinidine
• Racepinephrine
• Ramipril
• Ranitidine
• Rasagiline
• Remifentanil
• Reserpine
• Riociguat
• Ritonavir
• Rosiglitazone
• Rufinamide
• Sacubitril; Valsartan
• Safinamide
• Salmeterol
• Sedating H1-blockers
• Selegiline
• Selexipag
• Semaglutide
• Serotonin norepinephrine reuptake inhibitors
• Serotonin-Receptor Agonists
• Sertraline
• Sevoflurane
• SGLT2 Inhibitors
• Sibutramine
• Sodium Bicarbonate
• Sodium Lactate
• Sodium Oxybate
• Solriamfetol
• Sotalol
• St. John’s Wort, Hypericum perforatum
• Succinimides
• Sufentanil
• Sulfonylureas
• Tedizolid
• Telmisartan
• Terazosin
• Terbutaline
• Theophylline, Aminophylline
• Thiazide diuretics
• Thiazolidinediones
• Thiopental
• Thiothixene
• Thyroid hormones
• Tiagabine
• Timolol
• Tipranavir
• Topiramate
• Tramadol
• Trandolapril
• Trandolapril; Verapamil
• Tranylcypromine
• Trazodone
• Treprostinil
• Tricyclic antidepressants
• Tromethamine
• Umeclidinium; Vilanterol
• Valproic Acid, Divalproex Sodium
• Valsartan
• Vasodilators
• Venlafaxine
• Verapamil
• Vigabatrin
• Vilazodone
• Vortioxetine
• Yohimbine
• Ziprasidone
• Zonisamide