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Amifampridine Brand Names- FIRDAPSE | Ruzurgi
What is Amifampridine
Amifampridine is an oral aminopyridine potassium channel blocker used for the treatment of Lambert-Eaton myasthenic syndrome (LEMS).
During 2 double-blind, placebo-controlled discontinuation studies (n = 64), adult patients with LEMS randomized to placebo had statistically significantly greater worsening of muscular weakness according to Quantitative Myasthenia Gravis score change from baseline (amifampridine-placebo treatment difference least squares mean -1.7 [95% CI -3.4, 0]; p = 0.045 and -6.54 [95% CI -9.78, -3.29]; p = 0.0004).
Patients receiving placebo also had significant worsening of their impression of treatment effects on their well-being according to Subject Global Impression (SGI) score change from baseline vs. amifampridine.
The most common adverse reactions experienced by pediatric and adult patients include paresthesia, abdominal pain, dizziness, and nausea.
Seizures have been observed in patients taking amifampridine, and its use is contraindicated in patients with a history of seizure disorders.
Indications
- Lambert-Eaton syndrome
Side Effects
- abdominal pain
- anemia
- anxiety
- arthralgia
- asthenia
- back pain
- blurred vision
- cataracts
- constipation
- cystitis
- depression
- diarrhea
- dizziness
- dysesthesia
- dyspepsia
- dysphagia
- dyspnea
- elevated hepatic enzymes
- erythema
- fever
- gastroesophageal reflux
- headache
- hypercholesterolemia
- hypertension
- hypoesthesia
- infection
- influenza
- insomnia
- lymphadenopathy
- muscle cramps
- myasthenia
- nausea
- paresthesias
- peripheral edema
- seizures
- weakness
Monitoring Parameters
- neurologic function
Contraindications
- breast-feeding
- hepatic disease
- poor metabolizers
- pregnancy
- renal failure
- renal impairment
- seizure disorder
- seizures
- slow acetylation
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Alfentanil
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Aripiprazole
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine; Edrophonium
- atypical antipsychotic
- Azelastine; Fluticasone
- Beclomethasone
- Belladonna; Opium
- Benzhydrocodone; Acetaminophen
- Benzphetamine
- Betamethasone
- Brexpiprazole
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Butorphanol
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Ciclesonide
- Clomipramine
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Cyclobenzaprine
- Dalfampridine
- Deflazacort
- Desipramine
- Dexamethasone
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan; Promethazine
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Donepezil
- Donepezil; Memantine
- Doxepin
- Edrophonium
- Fentanyl
- Fludrocortisone
- Flunisolide
- Fluoxetine; Olanzapine
- Fluphenazine
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Formoterol; Mometasone
- Galantamine
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydrocortisone
- Hydromorphone
- Ibuprofen; Oxycodone
- Iloperidone
- Imipramine
- Isocarboxazid
- Levorphanol
- Lisdexamfetamine
- Loxapine
- Lumateperone
- Lurasidone
- Meperidine
- Meperidine; Promethazine
- Mesoridazine
- Methadone
- Methamphetamine
- Methylphenidate
- Methylprednisolone
- Molindone
- Mometasone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nalbuphine
- Neostigmine
- Nortriptyline
- Olanzapine
- Opiate Agonists
- Opiate Agonists-Antagonists
- Oxycodone
- Oxymorphone
- Paliperidone
- Pentazocine
- Pentazocine; Naloxone
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenelzine
- Phenothiazines
- Phentermine
- Phentermine; Topiramate
- Phenylephrine; Promethazine
- Physostigmine
- Prednisolone
- Prednisone
- Prochlorperazine
- Promethazine
- Propoxyphene
- Protriptyline
- Pyridostigmine
- Quetiapine
- Remifentanil
- Risperidone
- Rivastigmine
- Selegiline
- Sufentanil
- Tacrine
- Tapentadol
- Theophylline, Aminophylline
- Thiethylperazine
- Thioridazine
- Thiothixene
- Tramadol
- Tranylcypromine
- Triamcinolone
- Tricyclic antidepressants
- Trifluoperazine
- Trimipramine
- Ziprasidone
