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Amantadine Brand Names
GOCOVRI | OSMOLEX ER | Symmetrel
What is Amantadine
Amantadine is a synthetic antiviral agent with dopamine agonist properties.
It was introduced as an agent for prophylaxis of seasonal influenza A and was later found to cause symptomatic improvement in parkinsonism.
While approved for the prophylaxis and treatment of influenza A, the Centers for Disease Control and Prevention (CDC) recommends against using amantadine due to the development of resistant strains.
Amantadine is indicated for motor symptoms associated with Parkinson’s disease or drug-induced extrapyramidal reactions.
An extended-release capsule is used for the treatment of dyskinesia in patients with Parkinson’s disease receiving levodopa-based therapy.
Amantadine may be used off-label for multiple sclerosis-associated fatigue, neuroleptic malignant syndrome, and chorea associated with Huntington’s Disease.
During treatment of chronic conditions, practitioners should monitor for anticholinergic effects, new or worsening impulse control symptoms, or patient reports of falling asleep during activities of daily living.
Indications
- drug-induced extrapyramidal symptoms
- dyskinesia
- fatigue
- Huntington’s Disease (Huntington’s Chorea)
- influenza A virus
- influenza A virus infection
- neuroleptic malignant syndrome
- Parkinson’s disease
- parkinsonism
- seasonal influenza prophylaxis
Side Effects
- abnormal dreams
- agitation
- agranulocytosis
- amnesia
- anaphylactoid reactions
- anorexia
- antimicrobial resistance
- anxiety
- arrhythmia exacerbation
- arthralgia
- ataxia
- blurred vision
- cardiac arrest
- cataracts
- coma
- confusion
- constipation
- corneal edema
- corneal opacification
- cough
- delirium
- depression
- diarrhea
- dizziness
- drowsiness
- dysarthria
- dysphagia
- dyspnea
- dystonic reaction
- edema
- elevated hepatic enzymes
- euphoria
- fatigue
- fever
- hallucinations
- headache
- heart failure
- hyperbilirubinemia
- hyperhidrosis
- hyperkinesis
- hypertension
- hypertonia
- impulse control symptoms
- infection
- insomnia
- irritability
- keratitis
- leukocytosis
- leukopenia
- libido decrease
- libido increase
- livedo reticularis
- mania
- muscle cramps
- mydriasis
- nausea
- neuroleptic malignant syndrome
- neutropenia
- orthostatic hypotension
- paranoia
- paresthesias
- peripheral edema
- photosensitivity
- pruritus
- psychosis
- pulmonary edema
- rash
- seizures
- sinus tachycardia
- sudden sleep onset
- suicidal ideation
- tachypnea
- tremor
- urinary retention
- visual impairment
- vomiting
- weakness
- withdrawal
- xerophthalmia
- xerostomia
Monitoring Parameters
- neurologic function
- serum creatinine/BUN
Contraindications
- abrupt discontinuation
- amantadine hypersensitivity
- anticholinergic medications
- breast-feeding
- children
- closed-angle glaucoma
- coadministration with other CNS depressants
- depression
- dialysis
- driving or operating machinery
- eczema
- ethanol ingestion
- geriatric
- heart failure
- hepatic disease
- impulse control symptoms
- infants
- infertility
- melanoma
- narcolepsy
- neonates
- orthostatic hypotension
- peripheral edema
- pregnancy
- psychosis
- renal failure
- renal impairment
- rimantadine hypersensitivity
- schizophrenia
- seizure disorder
- sleep apnea
- substance abuse
- suicidal ideation
- syncope
Interactions
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Pentazocine
- Alosetron
- Ambenonium Chloride
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxapine
- Amphetamine; Dextroamphetamine Salts
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Benztropine
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bupropion
- Bupropion; Naltrexone
- Caffeine
- Caffeine; Ergotamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Chlordiazepoxide; Clidinium
- Chlorpromazine
- Clomipramine
- Clozapine
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Cyclobenzaprine
- Darifenacin
- Desipramine
- Dexmethylphenidate
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Dicyclomine
- Diethylpropion
- Disopyramide
- Donepezil
- Donepezil; Memantine
- Doxepin
- Ethanol
- Ezogabine
- Fesoterodine
- Flavoxate
- Fluoxetine; Olanzapine
- Fluphenazine
- Galantamine
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Homatropine; Hydrocodone
- Hydrochlorothiazide, HCTZ; Triamterene
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Imipramine
- Indacaterol; Glycopyrrolate
- Intranasal Influenza Vaccine
- Levodopa
- Loperamide
- Loperamide; Simethicone
- Maprotiline
- Memantine
- Mepenzolate
- Meperidine; Promethazine
- Mesoridazine
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methscopolamine
- Methylphenidate
- Metoclopramide
- Modafinil
- Molindone
- Nortriptyline
- Olanzapine
- Orphenadrine
- Oxybutynin
- Pemoline
- Pentazocine
- Pentazocine; Naloxone
- Perphenazine
- Perphenazine; Amitriptyline
- Phenothiazines
- Phenylephrine; Promethazine
- Prochlorperazine
- Promethazine
- Propantheline
- Protriptyline
- Quinidine
- Rivastigmine
- Scopolamine
- Sedating H1-blockers
- Solriamfetol
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Tacrine
- Talimogene Laherparepvec
- Thiethylperazine
- Thioridazine
- Thiothixene
- Tolterodine
- Triamterene
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethoprim
- Trimipramine
- Trospium
