Altretamine Brand Name– Hexalen
What is Altretamine
Altretamine is a synthetic antineoplastic agent effective in the treatment of some ovarian tumors resistant to alkylating agents.
It is an s-triazine derivative and is commercially available as an oral capsule.
Its unique mechanism of action is not related to any other commercially available antineoplastic.
Altretamine is also known as hexamethylmelamine, often abbreviated HMM.
Indications
- ovarian cancer
For the palliative treatment of recurrent or persistent ovarian cancer as a single agent following first-line combination chemotherapy
Side Effects
- alopecia
- anemia
- anorexia
- ataxia
- azotemia
- bone marrow suppression
- confusion
- depression
- dizziness
- elevated hepatic enzymes
- fatigue
- leukopenia
- nausea
- neurotoxicity
- peripheral neuropathy
- pruritus
- rash
- seizures
- thrombocytopenia
- vertigo
- vomiting
Monitoring Parameters
- CBC with differential
- neurologic function
- platelet count
Contraindications
- bone marrow suppression
- breast-feeding
- children
- dental disease
- dental work
- herpes infection
- infection
- intramuscular injections
- MAOI therapy
- neurotoxicity
- neutropenia
- pregnancy
- radiation therapy
- requires an experienced clinician
- thrombocytopenia
- vaccination
- varicella
- viral infection
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Aldesleukin, IL-2
- Alpha interferons
- Alteplase
- Amlodipine; Celecoxib
- Amobarbital
- Anticoagulants
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Argatroban
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Azelastine; Fluticasone
- Bacillus Calmette-Guerin Vaccine, BCG
- Barbiturates
- Beclomethasone
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Betamethasone
- Betrixaban
- Bivalirudin
- Budesonide
- Budesonide; Formoterol
- Butabarbital
- Carbamazepine
- Celecoxib
- Ciclesonide
- Cimetidine
- Clozapine
- Corticosteroids
- Corticotropin, ACTH
- Cortisone
- Dabigatran
- Dalteparin
- Danaparoid
- Deflazacort
- Desirudin
- Dexamethasone
- Diclofenac
- Diclofenac; Misoprostol
- Diflunisal
- Digoxin
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Echinacea
- Edoxaban
- Enoxaparin
- Esomeprazole; Naproxen
- Etodolac
- Famotidine; Ibuprofen
- Fenoprofen
- Filgrastim, G-CSF
- Fludrocortisone
- Flunisolide
- Flurbiprofen
- Fluticasone
- Fluticasone; Salmeterol
- Fluticasone; Umeclidinium; Vilanterol
- Fluticasone; Vilanterol
- Fondaparinux
- Formoterol; Mometasone
- Fosphenytoin
- Heparin
- Hydrocodone; Ibuprofen
- Hydrocortisone
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Indomethacin
- Influenza Virus Vaccine
- Intranasal Influenza Vaccine
- Isocarboxazid
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lepirudin
- Live Vaccines
- Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
- Measles/Mumps/Rubella Vaccines, MMR
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Mephobarbital
- Methohexital
- Methylprednisolone
- Mometasone
- Monoamine oxidase inhibitors
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nonsteroidal antiinflammatory drugs
- Oxaprozin
- Palifermin
- Pegfilgrastim
- Penicillamine
- Pentobarbital
- Pentosan
- Phenelzine
- Phenobarbital
- Phenytoin
- Piroxicam
- Platelet Inhibitors
- Prednisolone
- Prednisone
- Primidone
- Pyridoxine, Vitamin B6
- Rasagiline
- Reteplase, r-PA
- Rifampin
- Rivaroxaban
- Rofecoxib
- Rotavirus Vaccine
- Rubella Virus Vaccine Live
- Secobarbital
- Selegiline
- Smallpox and Monkeypox Vaccine, Live, Nonreplicating
- Smallpox Vaccine, Vaccinia Vaccine
- Streptokinase
- Sulindac
- Tbo-Filgrastim
- Tenecteplase
- Thiopental
- Thrombolytic Agents
- Tinzaparin
- Tolmetin
- Tranylcypromine
- Triamcinolone
- Tuberculin Purified Protein Derivative, PPD
- Typhoid Vaccine
- Urokinase
- Valdecoxib
- Varicella-Zoster Virus Vaccine, Live
- Warfarin
- Yellow Fever Vaccine, Live
