Aliskiren and Valsartan Brand Name– Valturna
What is Aliskiren and Valsartan
Aliskiren and valsartan are used together in an oral preparation for the treatment of hypertension.
Aliskiren is a direct renin inhibitor; valsartan is a specific angiotensin II receptor antagonist that selectively and competitively blocks the AT-1 receptor, which mediates the vasopressor and aldosterone effects of angiotensin II. Because valsartan does not inhibit angiotensin converting enzyme (ACE), it does not result in bradykinin accumulation, which is theorized to cause the cough and angioedema associated with ACE inhibitors.
However, angioedema has been rarely associated with valsartan and other angiotensin II antagonists.
The combination may be helpful in patients not adequately controlled on monotherapy, and in patients likely to require combination therapy to achieve their blood pressure goals.
Indications
- hypertension
For the treatment of hypertension
for initial therapy of hypertension in patients who are likely to need multiple drugs to achieve their blood pressure goals
Side Effects
- alopecia
- anaphylactoid reactions
- angioedema
- azotemia
- cough
- diarrhea
- dizziness
- elevated hepatic enzymes
- fatigue
- gout
- headache
- hepatitis
- hyperkalemia
- hypotension
- impotence (erectile dysfunction)
- infection
- influenza
- nephrolithiasis
- neutropenia
- oliguria
- peripheral edema
- pharyngitis
- rash
- renal failure (unspecified)
- rhabdomyolysis
- seizures
- teratogenesis
- thrombocytopenia
- vasculitis
- vertigo
Monitoring Parameters
- blood pressure
- heart rate
- LFTs
- serum bilirubin (total and direct)
- serum creatinine/BUN
- serum potassium
Contraindications
- ACE-inhibitor induced angioedema
- angioedema
- aortic stenosis
- biliary cirrhosis
- Black patients
- breast-feeding
- cardiomyopathy
- cerebrovascular disease
- children
- coronary artery disease
- diabetes mellitus
- geriatric
- heart failure
- hepatic disease
- hereditary angioedema
- hyperkalemia
- hypokalemia
- hyponatremia
- hypotension
- hypovolemia
- infants
- myocardial infarction
- neonates
- pregnancy
- renal artery stenosis
- renal failure
- renal impairment
- surgery
Interactions
- Acarbose
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Alprostadil
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amphetamine; Dextroamphetamine Salts
- Amyl Nitrite
- Angiotensin II
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Asenapine
- Atazanavir
- Atazanavir; Cobicistat
- Atorvastatin
- Atorvastatin; Ezetimibe
- Azilsartan
- Azilsartan; Chlorthalidone
- Baclofen
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Benzphetamine
- Boceprevir
- Bosentan
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bumetanide
- Cabergoline
- Calcium Phosphate, Supersaturated
- Canagliflozin; Metformin
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Celecoxib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Ciprofloxacin
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Clofarabine
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cobicistat
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Cyclosporine
- Daclatasvir
- Dapagliflozin; Metformin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diclofenac
- Diclofenac; Misoprostol
- Diethylpropion
- Diflunisal
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Elexacaftor; tezacaftor; ivacaftor
- Eltrombopag
- Elvitegravir
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Ephedrine
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- Esomeprazole; Naproxen
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethacrynic Acid
- Etodolac
- Etomidate
- Famotidine; Ibuprofen
- Fenofibric Acid
- Fenoldopam
- Fenoprofen
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluoxetine; Olanzapine
- Flurbiprofen
- Fosamprenavir
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fospropofol
- Fostamatinib
- Furosemide
- Gemfibrozil
- General anesthetics
- Glecaprevir; Pibrentasvir
- Glipizide; Metformin
- Glyburide; Metformin
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Potassium Guaiacolsulfonate
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Heparin
- Hetastarch; Dextrose; Electrolytes
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibritumomab Tiuxetan
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Iloperidone
- Iloprost
- Incretin Mimetics
- Indapamide
- Indomethacin
- Insulins
- Intravenous Lipid Emulsions
- Iodine; Potassium Iodide, KI
- Irbesartan
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Itraconazole
- Ketamine
- Ketoconazole
- Ketoprofen
- Ketorolac
- Lansoprazole; Naproxen
- Lesinurad
- Lesinurad; Allopurinol
- Levodopa
- Linagliptin; Metformin
- Lisdexamfetamine
- Lisinopril
- Lithium
- Lomitapide
- Loop diuretics
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Losartan
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lurasidone
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Meclofenamate Sodium
- Mefenamic Acid
- Meglitinides
- Meloxicam
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methamphetamine
- Methohexital
- Methylphenidate
- Miglitol
- Milrinone
- Minoxidil
- Mitotane
- Moexipril
- Nabumetone
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nateglinide
- Nebivolol; Valsartan
- Nefazodone
- Nesiritide, BNP
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Obeticholic Acid
- Olanzapine
- Olmesartan
- Ombitasvir; Paritaprevir; Ritonavir
- Oritavancin
- Oxaprozin
- Oxymetazoline
- Paliperidone
- Pazopanib
- Pentoxifylline
- Perindopril
- Perindopril; Amlodipine
- Phenelzine
- Phenylephrine
- Phenylephrine; Promethazine
- Piroxicam
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Ponatinib
- Posaconazole
- Potassium
- Potassium Acetate
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Potassium Gluconate
- Potassium Iodide, KI
- Potassium-sparing diuretics
- Pramlintide
- Prazosin
- Procainamide
- Procaine
- Propofol
- Pseudoephedrine
- Quinapril
- Quinidine
- Ramipril
- Rasagiline
- Repaglinide
- Rifampin
- Risperidone
- Ritonavir
- Rofecoxib
- Sacubitril; Valsartan
- Sapropterin
- Selegiline
- Sevoflurane
- SGLT2 Inhibitors
- Sildenafil
- Silodosin
- Simeprevir
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Spironolactone
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfonylureas
- Sulindac
- Telaprevir
- Telithromycin
- Telmisartan
- Telotristat Ethyl
- Tetracaine
- Thiazolidinediones
- Thiopental
- Thiothixene
- Tizanidine
- Tolmetin
- Tolvaptan
- Torsemide
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Triamterene
- Trimethoprim
- Tucatinib
- Valdecoxib
- Valsartan
- Vasodilators
- Verapamil
- Warfarin
- Yohimbine
- Zafirlukast
- Ziprasidone
- Zonisamide
