Alfuzosin Brand Name– Uroxatral
What is Alfuzosin
Alfuzosin is a short-acting, selective alpha-1 receptor antagonist. It is used for the symptomatic treatment of benign prostatic hyperplasia (BPH) in adult males and is most similar to prazosin, another short-acting alpha-1 blocker.
Meta-analyses have shown alfuzosin, doxazosin, tamsulosin, and terazosin to be comparable in the treatment of BPH; however, clinical uroselectivity may differ. Similar to tamsulosin, alfuzosin appears to be more specific for alpha-1a receptors than other alpha-blockers.
Alfuzosin has a low incidence of hypotension and sexual dysfunction at doses that are therapeutic for BPH. In one study, alfuzosin improved BPH symptoms progressively during 12 months of administration.
Alfuzosin was approved by the FDA in 2003.
Indications
- benign prostatic hyperplasia (BPH)
- erectile dysfunction (ED)
Side Effects
- abdominal pain
- angina
- angioedema
- asthenia
- atrial fibrillation
- bradycardia
- chest pain (unspecified)
- cholestasis
- confusion
- constipation
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- edema
- ejaculation dysfunction
- erythema
- fatigue
- floppy iris syndrome
- flushing
- gastritis
- headache
- hepatitis
- hypotension
- impotence (erectile dysfunction)
- infection
- insomnia
- jaundice
- myocardial infarction
- nausea
- orthostatic hypotension
- pharyngitis
- priapism
- pruritus
- QT prolongation
- rash
- rhinitis
- sinus tachycardia
- sinusitis
- syncope
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vertigo
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- alcoholism
- angina
- bradycardia
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- children
- coronary artery disease
- diabetes mellitus
- females
- geriatric
- heart failure
- hepatic disease
- hypertension
- hypocalcemia
- hypokalemia
- hypomagnesemia
- hypotension
- infants
- long QT syndrome
- malnutrition
- myocardial infarction
- ocular surgery
- orthostatic hypotension
- pregnancy
- priapism
- prostate cancer
- QT prolongation
- renal failure
- renal impairment
- surgery
- syncope
- thyroid disease
Interactions
- Abarelix
- Acebutolol
- Alpha-blockers
- Ambrisentan
- Amiodarone
- Amitriptyline
- Amitriptyline; Chlordiazepoxide
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amprenavir
- Amyl Nitrite
- Anagrelide
- Apomorphine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Arsenic Trioxide
- Artemether; Lumefantrine
- Asenapine
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atomoxetine
- Avanafil
- Azithromycin
- Bedaquiline
- Bendroflumethiazide; Nadolol
- Bepridil
- Beta-adrenergic blockers
- Betaxolol
- Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Brimonidine; Timolol
- Buprenorphine
- Buprenorphine; Naloxone
- Carteolol
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- Ceritinib
- Chloramphenicol
- Chloroprocaine
- Chloroquine
- Chlorpromazine
- Cimetidine
- Ciprofloxacin
- Cisapride
- Citalopram
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- Clofazimine
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- Clozapine
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- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Conivaptan
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- Elbasvir; Grazoprevir
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- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Enalapril; Felodipine
- Encorafenib
- Enflurane
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- food
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- Midostaurin
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