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Adenosine Brand Names- Adenocard | Adenoscan
What is Adenosine
Adenosine, a ubiquitous, endogenous purine nucleotide, is available commercially for use as an antiarrhythmic agent in the management of reentrant paroxysmal supraventricular tachycardias including those associated with Wolff-Parkinson-White (WPW) syndrome.
Because of its unique chemical structure, adenosine cannot be categorized as an antiarrhythmic agent using the Vaughn-Williams classification scheme. Although adenosine is not effective in converting ventricular tachycardia, except in the rare case of exercise-induced VT in an otherwise healthy heart, it is an effective “diagnostic aid” in determining the underlying rhythm in wide complex tachycardias.
In this case, adenosine is preferred over verapamil because its effects are so transient that life-threatening hypotension does not ensue.
Adenosine is equal in effectiveness to verapamil in converting PSVT, but adenosine is less toxic.
Adenosine is not effective in managing basic atrial arrhythmias such as atrial flutter, atrial fibrillation, or atrial ectopic foci.
Indications
- coronary artery disease diagnosis
- paroxysmal supraventricular tachycardia (PSVT)
- pulmonary hypertension diagnosis
- wide-complex tachycardia diagnosis
- Wolff-Parkinson-White (WPW) syndrome
For the treatment of stable reentry supraventricular tachycardia or paroxysmal supraventricular tachycardia (PSVT), including PSVT in patients with Wolff-Parkinson-White (WPW) syndrome
Side Effects
- anxiety
- arrhythmia exacerbation
- atrial fibrillation
- AV block
- back pain
- blurred vision
- bradycardia
- bronchospasm
- cardiac arrest
- chest pain (unspecified)
- cough
- diaphoresis
- dizziness
- drowsiness
- dyspnea
- flushing
- headache
- heart failure
- hypertension
- hypotension
- injection site reaction
- intracranial bleeding
- metallic taste
- myocardial infarction
- nasal congestion
- nausea
- otalgia
- palpitations
- paresthesias
- respiratory arrest
- scotomata
- seizures
- sinus tachycardia
- stroke
- syncope
- tremor
- urinary urgency
- vaginal pain
- ventricular fibrillation
- vomiting
- weakness
- xerostomia
Monitoring Parameters
- blood pressure
- ECG
- heart rate
Contraindications
- acute bronchospasm
- angina
- asthma
- asystole
- atrial fibrillation
- atrial flutter
- autonomic neuropathy
- AV block
- bradycardia
- breast-feeding
- bronchitis
- bundle-branch block
- cardiac arrest
- chronic obstructive pulmonary disease (COPD)
- emphysema
- geriatric
- heart transplant
- hypotension
- hypovolemia
- myocardial infarction
- pericardial effusion
- pericarditis
- pregnancy
- respiratory arrest
- seizure disorder
- sick sinus syndrome
- valvular heart disease
- ventricular arrhythmias
- ventricular tachycardia
- Wolff-Parkinson-White syndrome
Interactions
- Aspirin, ASA; Dipyridamole
- Beta-adrenergic blockers
- Caffeine
- Carbamazepine
- Digoxin
- Dipyridamole
- Ginger, Zingiber officinale
- Green Tea
- Inotersen
- Methylxanthines
- Nicotine
- tobacco
