Acrivastine and Pseudoephedrine

Acrivastine and Pseudoephedrine Brand Name– Semprex-D

What is Acrivastine and Pseudoephedrine

Acrivastine and pseudoephedrine are used together in an oral preparation to treat the symptoms of seasonal allergic rhinitis and associated nasal congestion; it is intended for short-term (14 days or less) use in adult and pediatric patients 12 years and older.

Acrivastine is a second-generation, lower sedating antihistamine (H1-blocker) that dries the nasal and sinus passages.

Due to reduced lipophilicity, acrivastine has lower CNS penetration and adverse effects than traditional antihistamines. Acrivastine does not exhibit significant anticholinergic activity or prolong the QT interval.

Pseudoephedrine is a sympathomimetic agent that stimulates alpha-1 adrenergic receptors in vascular smooth muscle. This causes vasoconstriction, resulting in shrinkage of nasal mucous membranes, reduction of tissue hyperemia and edema, and an increase in nasal airway patency.

The combination of acrivastine and pseudoephedrine was FDA-approved in 1994.

Indications

1. allergic rhinitis
2. nasal congestion

Side Effects

1. acute generalized exanthematous pustulosis (AGEP)
2. anaphylactic shock
3. anaphylactoid reactions
4. angina
5. angioedema
6. anxiety
7. arrhythmia exacerbation
8. asthenia
9. blurred vision
10. bronchospasm
11. colitis
12. contact dermatitis
13. cough
14. dizziness
15. drowsiness
16. dysmenorrhea
17. dyspepsia
18. dysuria
19. erythema multiforme
20. hallucinations
21. headache
22. hypertension
23. insomnia
24. myocardial infarction
25. nausea
26. ocular hypertension
27. palpitations
28. pharyngitis
29. photophobia
30. premature ventricular contractions (PVCs)
31. psychosis
32. rash
33. seizures
34. sinus tachycardia
35. stroke
36. supraventricular tachycardia (SVT)
37. vomiting
38. xerophthalmia
39. xerostomia

Monitoring Parameters

• laboratory monitoring not necessary

Contraindications

• acute myocardial infarction
• angina
• breast-feeding
• cardiac arrhythmias
• cardiac disease
• cardiomyopathy
• children
• closed-angle glaucoma
• coadministration with other CNS depressants
• coronary artery disease
• diabetes mellitus
• driving or operating machinery
• ethanol ingestion
• geriatric
• GI obstruction
• heart failure
• hypertension
• hyperthyroidism
• infants
• MAOI therapy
• neonates
• peptic ulcer disease
• pregnancy
• prostatic hypertrophy
• renal failure
• renal impairment
• tachycardia
• thyrotoxicosis
• urinary retention

Interactions

• Acarbose
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