Acetaminophen and Pentazocine Brand Name – Talacen
What is Acetaminophen and Pentazocine
Acetaminophen and pentazocine are used together as an oral analgesic product.
Acetaminophen is a non-narcotic analgesic with antipyretic activities. Pentazocine is a narcotic agonist-antagonist analgesic with an approximately equivalent analgesic effect of codeine on a mg for mg basis following oral administration.
Use of pentazocine may result in less respiratory and CNS depressant effects than would use of a pure agonist (e.g., codeine); however, drug accumulation, dependence, and tolerance are associated with its prolonged use.
The combination of acetaminophen with pentazocine may produce a greater analgesic effect than that produced by either agent alone. The FDA approved acetaminophen; pentazocine (Talacen) in September 1982 for the treatment of mild to moderate pain.
Indications
- mild pain
- moderate pain
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactic shock
- anorexia
- blurred vision
- chills
- confusion
- constipation
- depression
- diarrhea
- dizziness
- drowsiness
- edema
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- euphoria
- excitability
- flushing
- hallucinations
- headache
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hyperhidrosis
- hypotension
- impaired cognition
- insomnia
- irritability
- leukopenia
- nausea
- paresthesias
- physiological dependence
- psychological dependence
- purpura
- rash
- respiratory depression
- sinus tachycardia
- Stevens-Johnson syndrome
- syncope
- tinnitus
- tolerance
- toxic epidermal necrolysis
- tremor
- urinary retention
- urticaria
- vomiting
- weakness
- withdrawal
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- acetaminophen hypersensitivity
- acute myocardial infarction
- alcoholism
- asthma
- biliary tract disease
- breast-feeding
- children
- chronic obstructive pulmonary disease (COPD)
- CNS depression
- driving or operating machinery
- ethanol intoxication
- geriatric
- head trauma
- hepatic disease
- hypoxemia
- increased intracranial pressure
- infants
- intracranial mass
- labor
- MAOI therapy
- neonates
- obstetric delivery
- potential for overdose or poisoning
- pregnancy
- premature neonates
- pulmonary disease
- renal failure
- renal impairment
- respiratory depression
- respiratory insufficiency
- sleep apnea
- substance abuse
- sulfite hypersensitivity
Interactions
- Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Alfentanil
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Alprazolam
- Amantadine
- Amifampridine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amitriptyline; Chlordiazepoxide
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amobarbital
- Amoxapine
- Antacids
- Anticholinergics
- Aprepitant, Fosaprepitant
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atenolol; Chlorthalidone
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- atypical antipsychotic
- Azelastine
- Azelastine; Fluticasone
- Azilsartan; Chlorthalidone
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Bismuth Subsalicylate
- Bismuth Subsalicylate; Metronidazole; Tetracycline
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Bumetanide
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Busulfan
- Butabarbital
- Butorphanol
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Cariprazine
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Charcoal
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorothiazide
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Cholestyramine
- Choline Salicylate; Magnesium Salicylate
- Clobazam
- Clonazepam
- Clorazepate
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Dapsone
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deutetrabenazine
- Dextromethorphan; Promethazine
- Diazepam
- Dicyclomine
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Disopyramide
- Dronabinol
- Droperidol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Eltrombopag
- Enalapril; Hydrochlorothiazide, HCTZ
- Entacapone
- Eprosartan; Hydrochlorothiazide, HCTZ
- Esketamine
- Estazolam
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Exenatide
- Ezogabine
- Fentanyl
- Flavoxate
- Flibanserin
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- Fosinopril; Hydrochlorothiazide, HCTZ
- Furosemide
- Gabapentin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Haloperidol
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyprogesterone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Iloperidone
- Imatinib
- Indacaterol; Glycopyrrolate
- Indapamide
- Insulin Glargine; Lixisenatide
- Isavuconazonium
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Lamivudine, 3TC; Zidovudine, ZDV
- Lamotrigine
- Lanthanum Carbonate
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levomethadyl
- Levorphanol
- Lidocaine
- Lidocaine; Prilocaine
- Linezolid
- Lixisenatide
- Lofexidine
- Lomitapide
- Loop diuretics
- Lopinavir; Ritonavir
- Lorazepam
- Lumateperone
- Lurasidone
- Magnesium Salicylate
- Magnesium Salts
- Maprotiline
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Mepivacaine
- Mepivacaine; Levonordefrin
- Meprobamate
- Mesoridazine
- Methadone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methocarbamol
- Methohexital
- Methscopolamine
- Methyclothiazide
- Methylene Blue
- Metolazone
- Metyrapone
- Midazolam
- Minocycline
- Mipomersen
- Mirtazapine
- Mitotane
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nalmefene
- Naloxone
- Naltrexone
- Nefazodone
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oxazepam
- Oxybutynin
- Oxycodone
- Oxymorphone
- Ozanimod
- Paliperidone
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Pentazocine; Naloxone
- Pentobarbital
- Perphenazine
- Perphenazine; Amitriptyline
- Phenobarbital
- Phenothiazines
- Phenylephrine; Promethazine
- Pimozide
- Pneumococcal Vaccine, Polyvalent
- Posaconazole
- Potassium-sparing diuretics
- Pramipexole
- Pramlintide
- Pregabalin
- Prilocaine
- Prilocaine; Epinephrine
- Primidone
- Procarbazine
- Prochlorperazine
- Promethazine
- Propantheline
- Propoxyphene
- Quazepam
- Quetiapine
- Rasagiline
- Remifentanil
- Rifabutin
- Rifampin
- Risperidone
- Ritonavir
- Ropivacaine
- Rotigotine
- Salsalate
- Scopolamine
- Secobarbital
- Sedating H1-blockers
- Segesterone Acetate; Ethinyl Estradiol
- Selective serotonin reuptake inhibitors
- Serotonin norepinephrine reuptake inhibitors
- Sibutramine
- Skeletal Muscle Relaxants
- Sodium Bicarbonate
- Solifenacin
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulfinpyrazone
- Suvorexant
- Tapentadol
- Tedizolid
- Telaprevir
- Telotristat Ethyl
- Temazepam
- Tetrabenazine
- Tetracaine
- Thalidomide
- Thiazide diuretics
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Tizanidine
- tobacco
- Tolcapone
- Tolterodine
- Torsemide
- Tramadol
- Trazodone
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Trimetrexate
- Trospium
- Vemurafenib
- Vigabatrin
- Vilazodone
- Vortioxetine
- Warfarin
- Zaleplon
- Ziconotide
- Zidovudine, ZDV
- Ziprasidone
- Zolmitriptan
- Zolpidem
