Acalabrutinib Brand Name – CALQUENCE
What is Acalabrutinib
Acalabrutinib is a Bruton tyrosine kinase (BTK) inhibitor approved for the treatment of mantle cell lymphoma in adult patients who have received at least 1 prior therapy and as a single-agent or in combination with obinutuzumab in adult patients with chronic lymphocytic leukemia or small lymphocytic lymphoma.
Indications
- chronic lymphocytic leukemia (CLL)
- macroglobulinemia
- mantle cell lymphoma (MCL)
- small lymphocytic lymphoma (SLL)
Side Effects
- abdominal pain
- anemia
- arthralgia
- asthenia
- atrial fibrillation
- atrial flutter
- back pain
- bleeding
- bone pain
- constipation
- diarrhea
- diarrhea
- ecchymosis
- elevated hepatic enzymes
- epistaxis
- fatigue
- headache
- hematoma
- hemoptysis
- hepatitis B exacerbation
- hyperbilirubinemia
- hypertension
- hyperuricemia
- infection
- intracranial bleeding
- lethargy
- lymphocytosis
- menorrhagia
- musculoskeletal pain
- myalgia
- nausea
- nephrotoxicity
- neutropenia
- new primary malignancy
- petechiae
- pharyngitis
- progressive multifocal leukoencephalopathy
- rash
- sinusitis
- skin cancer
- thrombocytopenia
- tracheitis
- vomiting
Monitoring Parameters
- CBC with differential
- ECG
- LFTs
- pregnancy testing
- skin cancer screening exam
Contraindications
- anemia
- anticoagulant therapy
- bleeding
- breast-feeding
- cardiac arrhythmias
- contraception requirements
- dental work
- fungal infection
- geriatric
- hepatic disease
- hepatitis B exacerbation
- hypertension
- infection
- intracranial bleeding
- neutropenia
- new primary malignancy
- pregnancy
- pregnancy testing
- progressive multifocal leukoencephalopathy
- reproductive risk
- sunlight (UV) exposure
- surgery
- thrombocytopenia
- viral infection
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Alpelisib
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amiodarone
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Antacids
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Omeprazole
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Brigatinib
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Carbamazepine
- Ceritinib
- Chloramphenicol
- Cimetidine
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexlansoprazole
- Diltiazem
- Dolutegravir
- Dolutegravir; Lamivudine
- Dolutegravir; Rilpivirine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dronedarone
- Duvelisib
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Encorafenib
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esomeprazole
- Esomeprazole; Naproxen
- Famotidine
- Famotidine; Ibuprofen
- Fedratinib
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Glecaprevir; Pibrentasvir
- grapefruit juice
- H2-blockers
- Idelalisib
- Imatinib
- Indinavir
- Irinotecan
- Irinotecan Liposomal
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ivosidenib
- Ketoconazole
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lansoprazole
- Lansoprazole; Naproxen
- Ledipasvir; Sofosbuvir
- Lefamulin
- Letermovir
- Lopinavir; Ritonavir
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Magnesium Hydroxide
- Mephobarbital
- Methotrexate
- Mifepristone
- Mitotane
- Mitoxantrone
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nicardipine
- Nilotinib
- Nizatidine
- Ombitasvir; Paritaprevir; Ritonavir
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Ozanimod
- Pantoprazole
- Pazopanib
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Quinine
- Rabeprazole
- Ranitidine
- Ribociclib
- Ribociclib; Letrozole
- Rifampin
- Rimegepant
- Ritonavir
- Rosuvastatin
- Saquinavir
- Sodium Bicarbonate
- Sofosbuvir
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- St. John’s Wort, Hypericum perforatum
- Sulfasalazine
- Talazoparib
- Telithromycin
- Tenofovir Alafenamide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Tipranavir
- Topotecan
- Trandolapril; Verapamil
- Tucatinib
- Ubrogepant
- Verapamil
- Voriconazole
