What are Terry nails and Muehrcke nails? Terry nails are characterized by uniform white discoloration of the nail, with the distal 1 to 2 mm remaining pink. The white color results from abnormalities in the nail bed vasculature and is most commonly seen in patients with liver cirrhosis, heart disease, and diabetes. Muehrcke nails are …
What conditions produce yellowish discoloration of the skin? Carotenoderma caused by excessive ingestion of carotene (e.g., yellow and orange vegetables such as carrots, sweet potatoes, and squash), lycopenodermia caused by excessive ingestion of lycopenes (e.g., red vegetables such as tomatoes and rose hips), and systemic administration of quinacrine can all cause yellowish skin discoloration unrelated …
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Where is clinical jaundice first visible? The mucosae of the soft palate and sublingual region are often the first mucocutaneous surfaces to appear yellow in response to hyperbilirubinemia. This is likely because of the thin mucosal surface in these anatomic locations. Bilirubin also has a strong affinity for elastin, which accounts for its early appearance …
At what serum level of bilirubin do adults and infants develop clinically noticeable jaundice? Adults develop clinically detectable jaundice when serum levels of bilirubin reach 2.5 to 3 mg/dL, whereas infants may not demonstrate visually detectable jaundice (from the French word jaune, meaning yellow) until serum levels reach 6 to 8 mg/dL. Hyperbilirubinemia precedes jaundice by several …
GI manifestations of common endocrine syndromes and neoplastic disorders Autoimmune polyglandular syndromes and multiple endocrine neoplasias affect various endocrine systems, but they also affect the GI tract. The below table provides a summary. GI Manifestations of Common Endocrine Syndromes GI Manifestations Non-GI Manifestations APS Type 1 Oral candidiasis, pernicious anemia, celiac disease HypoparathyroidismAdrenal insufficiencyHypogonadismAutoimmune thyroid diseaseAlopecia …
GI side effects of exogenous oral corticosteroids GI side effects of steroids include oral and esophageal fungal infection, esophagitis, peptic ulcer, GI bleeding, and rarely pancreatitis. Transaminitis can also occur. Such symptoms usually occur if steroid administration is prolonged and at high doses.
GI manifestations associated with common endocrine conditions GI Manifestations of Common Endocrine DISORDERS Endocrine Disorder GI Manifestation Hypothyroidism Weight gain, reduced taste sensation, constipation, ascites in severe hypothyroidism Hyperthyroidism Weight loss, increased appetite, hyperdefecation Papillary thyroid cancer (cribiform morular variant) Familial adenomatous polyposis, increased risk of colorectal cancer Hypercalcemia Constipation, nausea, peptic ulcer disease, pancreatitis …
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