What is Tenecteplase Tenecteplase is a thrombolytic agent which may be administered as a single, rapid IV bolus for the treatment of acute myocardial infarction. Tenecteplase is a modified form of human tissue plasminogen activator that binds to fibrin and converts plasminogen to plasmin. Tenecteplase is produced by recombinant DNA technology from genetically modified Chinese …
What is Tenapanor Tenapanor is a sodium/hydrogen exchanger 3 (NHE3) inhibitor indicated for irritable bowel syndrome with constipation (IBS-C) in adults. Tenapanor is minimally absorbed from the GI tract and acts locally to increase bowel movements and decrease abdominal pain. In clinical studies, tenapanor demonstrated a statistically significant reduction in constipation and abdominal pain in …
What is Temsirolimus Temsirolimus, an ester analog of sirolimus, is an inhibitor of mammalian target of rapamycin (mTOR) and was the first FDA-approved mTOR antagonist for the treatment of renal cell cancer (RCC). Treatment with temsirolimus significantly improved overall survival and progression-free survival compared with interferon alfa in patients with previously untreated advanced RCC (clear …
What is Temozolomide Temozolomide is an alkylating agent that is indicated for the treatment of newly diagnosed glioblastoma multiforme in combination with radiotherapy followed by monotherapy maintenance therapy and for the treatment of refractory anaplastic astrocytoma in patients who have experienced disease progression after a nitrosourea and procarbazine-containing regimen. Severe hematologic toxicity and hepatotoxicity have …
What is Temazepam Temazepam is an oral benzodiazepine used as a hypnotic agent in the short-term management of insomnia. It is often preferable to flurazepam for insomnia, particularly in the elderly or patients with liver disease, because temazepam has a shorter half-life and does not have active metabolites. Temazepam was approved by the FDA in …
What is Telotristat Ethyl Telotristat ethyl is an orally available tryptophan hydroxylase inhibitor. Tryptophan hydroxylase mediates the rate-limiting step in the formation of serotonin, which is overproduced in patients with carcinoid syndrome and contributes to altered gastrointestinal secretion, motility, inflammation, and sensation. In a multicenter, randomized, double-blind clinical trial, telotristat ethyl significantly decreased the number …
What is Telmisartan Telmisartan is an angiotensin II receptor antagonist, also known as an angiotensin II receptor blocker (ARB). It is indicated for the treatment of hypertension and cardiovascular risk reduction in patients who are unable to take angiotensin-converting enzyme (ACE) inhibitors. Telmisartan has also been used off-label to prevent the progression of renal dysfunction …