What is Tenapanor

Tenapanor is a sodium/hydrogen exchanger 3 (NHE3) inhibitor indicated for irritable bowel syndrome with constipation (IBS-C) in adults.

Tenapanor is minimally absorbed from the GI tract and acts locally to increase bowel movements and decrease abdominal pain. In clinical studies, tenapanor demonstrated a statistically significant reduction in constipation and abdominal pain in adults with IBS-C.

The primary endpoints were at least a 30% reduction in the weekly average abdominal pain score compared with baseline and an increase of at least 1 complete spontaneous bowel movement (CSBM) in weekly average from baseline, in the same week, for at least 6 of the first 12 treatment weeks. In both trials, patients receiving tenapanor met the primary endpoints (Trial 1: 37% versus 24% placebo, Trial 2: 27% versus 19% placebo).

Tenapanor carries a boxed warning for risk of serious dehydration in pediatric patients. Tenapanor was approved by the FDA in September 2019.

Brand Name



  • constipation
  • irritable bowel syndrome

For the treatment of irritable bowel syndrome with constipation (IBS-C)

Side Effects

  1. abdominal pain
  2. dehydration
  3. diarrhea
  4. diarrhea
  5. dizziness
  6. flatulence
  7. GI bleeding
  8. hyperkalemia

Monitoring Parameters

  • laboratory monitoring not necessary


  • abdominal pain
  • breast-feeding
  • children
  • cholelithiasis
  • Crohn’s disease
  • diarrhea
  • diverticulitis
  • fecal impaction
  • gastric cancer
  • GI disease
  • GI obstruction
  • infants
  • inflammatory bowel disease
  • neonates
  • pregnancy


No information is available regarding drug interactions associated with Tenapanor 


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