Vinorelbine Brand Name Navelbine What is Vinorelbine Vinorelbine is a semi-synthetic vinca alkaloid derived from the Catharanthus roseus or Madagascar periwinkle plant. It acts as a microtubule inhibitor, causing cellular instability and preventing mitosis at metaphase. Microtubules are responsible for intracellular transport, maintenance of cell shape, polarity, cell signaling, and mitosis. During mitosis, microtubules form …
Vincristine Liposomal Brand Name Marqibo What is Vincristine Liposomal Liposomal vincristine is a sphingomyelin/cholesterol liposome-encapsulated formulation of vincristine sulfate, a vinca alkaloid agent. It is indicated for the treatment of adult patients with Philadelphia chromosome-negative acute lymphoblastic leukemia in second or greater relapse or whose disease has progressed following 2 or more anti-leukemia therapies. Neurologic …
Vincristine Brand Names Oncovin Vincasar PFS What is Vincristine Vincristine is a member of the vinca alkaloid class of naturally occurring cancer chemotherapy agents, which are extracted from the Catharanthus rosea or periwinkle plant. Vincristine is similar to vinblastine in action and structure, but their toxicities and spectrum of activity differ significantly. Vincristine has increased cellular retention …
Vinblastine Brand Name Velban What is Vinblastine Vinblastine is a member of the vinca alkaloid class of naturally occurring cancer chemotherapy agents, which are extracted from the Catharanthus rosea or periwinkle plant. Vinblastine is similar to vincristine in action and structure, but their toxicities and spectrum of activity differ significantly. Vinblastine has the shortest terminal half-life and …
Vilazodone Brand Name VIIBRYD What is Vilazodone Vilazodone is an oral antidepressant that is a dual selective serotonin reuptake inhibitor and partial serotonin 5-HT1A agonist and is often described as a serotonin modulator. Vilazodone is used for the treatment of major depressive disorder in adults. Vilazodone is extensively metabolized in the liver, and dosage adjustments …
Vigabatrin Brand Names Sabril VIGADRONE What is Vigabatrin Vigabatrin, an oral anticonvulsant, was synthesized in 1974 as a structural analog of gamma-aminobutyric acid (GABA) and was designed to inhibit the metabolism of GABA. Decreased concentrations of GABA have been associated with certain forms of epilepsy. Vigabatrin has been investigated for the treatment of many seizure …
What is Vidarabine (adenine arabinoside, Ara-A) NOTE: This drug is discontinued in the US. Vidarabine (adenine arabinoside, Ara-A) is an antiviral drug, produced from fermentation cultures of Streptomyces antibioticus. Vidarabine has antiviral activity against herpes simplex types I and II, varicella-zoster virus, cytomegalovirus, vaccinia, and hepatitis B. Vidarabine also inhibits the formation of myeloid precursor cells in …