Imipenem Cilastatin Brand Name– Primaxin What is Imipenem Cilastatin Imipenem is a beta-lactam antibiotic derived from thienamycin and is the first drug to be classified as a carbapenem antibiotic. Cilastatin is added as an inhibitor of dehydropeptidase-1, an enzyme found in the renal tubule border that metabolizes imipenem. Without cilastatin, imipenem is rapidly metabolized and …
Imiglucerase Brand Name– Cerezyme What is Imiglucerase Imiglucerase is parenteral enzyme used in the treatment of patients with Gaucher’s disease. Imiglucerase replaces the endogenous enzyme beta-glucocerebrosidase. Imiglucerase is produced by recombinant DNA technology using Chinese hamster ovary cell cultures and differs from the endogenous enzyme by one amino acid at position 495 where histidine is …
Imatinib Brand Name– Gleevec What is Imatinib Imatinib is an oral BCR-ABL tyrosine kinase inhibitor. It is indicated for the treatment of adults and pediatric patients with newly diagnosed chronic-phase Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML); chronic-phase, accelerated-phase, or myeloid or lymphoid blast-phase Ph+ CML after failure of interferon-alfa therapy; relapsed or refractory Ph+ …
Iloprost Brand Name– Ventavis What is Iloprost Iloprost is an inhaled prostaglandin approved for the treatment of pulmonary hypertension. It is a stable, second generation structural analog of the endogenous prostaglandin prostacyclin, with a potency which is ten-fold greater than first generation stable analogs (i.e., carbaprostacyclin). Intravenous prostacyclin was the first drug shown to reduce …
Iloperidone Brand Name– Fanapt What is Iloperidone Iloperidone is an oral atypical antipsychotic belonging to the benzisoxazole/benzoisothiazol derivatives class. Iloperidone is used for the acute and maintenance treatment of schizophrenia in adult patients. In a long-term study, iloperidone was effective in delaying time to relapse in patients with schizophrenia who were stabilized on doses ranging …
Ifosfamide Brand Name– Ifex What is Ifosfamide Ifosfamide is an intravenous alkylating agent related to the nitrogen mustards; it is a prodrug requiring activation by CYP3A4 for its cytotoxic activity. It is a synthetic analog of cyclophosphamide, although it has a different spectrum of activity. Ifosfamide carries a black box warning for myelosuppression, neurotoxicity, nephrotoxicity, …
Idursulfase Brand Name– Elaprase What is Idursulfase Idursulfase a purified form of human iduronate-2-sulfatase, is for the treatment of Hunter syndrome, which is also called mucopolysaccharidosis (MPS) II. Patients with the syndrome do not produce enough of a functional lysosomal enzyme called iduronate-2-sulfatase because of a a genetic defect. The deficiency of iduronate-2-sulfatase production causes …